Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival
Malaysia has one of the highest national incidences of Nasopharyngeal carcinoma (NPC) in South-East Asia. Treating patients with metastatic NPC is often a challenge as patients develop resistance to systemic anti-cancer therapies such as chemotherapy and retreating local recurrence with radiother...
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my-usm-ep.601272024-03-12T01:53:26Z Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival 2022-11 Abdul Rahman, Siti Fairus QH1-278.5 Natural history (General) Malaysia has one of the highest national incidences of Nasopharyngeal carcinoma (NPC) in South-East Asia. Treating patients with metastatic NPC is often a challenge as patients develop resistance to systemic anti-cancer therapies such as chemotherapy and retreating local recurrence with radiotherapy have many limitations. Hence, improved treatment strategies are needed for better patient outcome. Upregulation of the anti-apoptotic protein BCL-2 is one of the strategies that cancer cells adopt to evade cell death. Hence, these proteins have become attractive therapeutic targets. Given that different cell population rely on different anti-apoptotic proteins for survival, it is crucial to determine which proteins are important for NPC cell survival. Previous study reported that co-inhibition of BCL-2 and BCL-XL did not induce cell killing in NPC cells, which indicate that either MCL-1 or BFL-1 may play an important role in the survival the NPC cells. Given that the roles of MCL-1 and BFL-1 for NPC cell survival are under-explored, this study will primarily focus on delineating the functional roles of these two molecules for cell survival using gene editing and pharmacological approaches. 2022-11 Thesis http://eprints.usm.my/60127/ http://eprints.usm.my/60127/1/24%20Pages%20from%20SITI%20FAIRUS%20BINTI%20ABDUL%20RAHMAN.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Kajihayat |
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QH1-278.5 Natural history (General) Abdul Rahman, Siti Fairus Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival |
description |
Malaysia has one of the highest national incidences of Nasopharyngeal
carcinoma (NPC) in South-East Asia. Treating patients with metastatic NPC is often a
challenge as patients develop resistance to systemic anti-cancer therapies such as
chemotherapy and retreating local recurrence with radiotherapy have many limitations.
Hence, improved treatment strategies are needed for better patient outcome. Upregulation
of the anti-apoptotic protein BCL-2 is one of the strategies that cancer cells
adopt to evade cell death. Hence, these proteins have become attractive therapeutic
targets. Given that different cell population rely on different anti-apoptotic proteins for
survival, it is crucial to determine which proteins are important for NPC cell survival.
Previous study reported that co-inhibition of BCL-2 and BCL-XL did not induce cell
killing in NPC cells, which indicate that either MCL-1 or BFL-1 may play an important
role in the survival the NPC cells. Given that the roles of MCL-1 and BFL-1 for NPC
cell survival are under-explored, this study will primarily focus on delineating the
functional roles of these two molecules for cell survival using gene editing and
pharmacological approaches. |
format |
Thesis |
qualification_name |
Doctor of Philosophy (PhD.) |
qualification_level |
Doctorate |
author |
Abdul Rahman, Siti Fairus |
author_facet |
Abdul Rahman, Siti Fairus |
author_sort |
Abdul Rahman, Siti Fairus |
title |
Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival |
title_short |
Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival |
title_full |
Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival |
title_fullStr |
Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival |
title_full_unstemmed |
Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival |
title_sort |
anti-apoptotic proteins mcl-1 and bcl-xl are crucial for nasopharyngeal carcinoma cell survival |
granting_institution |
Perpustakaan Hamzah Sendut |
granting_department |
Pusat Pengajian Sains Kajihayat |
publishDate |
2022 |
url |
http://eprints.usm.my/60127/1/24%20Pages%20from%20SITI%20FAIRUS%20BINTI%20ABDUL%20RAHMAN.pdf |
_version_ |
1794024093786308608 |