Development Of Cisplatin Delivery Nanosystem With Chitosan-coated Titania Nanotube Arrays Platform Targeting For Nasopharyngeal Carcinoma

Present chemodrug treatment for advanced-stage nasopharyngeal carcinoma (NPC) via cisplatin (CDDP) have limitations such as non-specific biodistribution, dose-limiting toxicities, the emergence of resistant cancer cells and various side effects. Targeted and controlled release of CDDP delivery using...

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Main Author:	Effendy, Wan Nuramiera Faznie Wan Eddis
Format:	Thesis
Language:	English
Published:	2022
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/60152/1/WAN%20NURAMIERA%20FAZNIE%20BT%20WAN%20EDDIS%20EFFENDY%20-%20TESIS24.pdf
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spelling	my-usm-ep.601522024-03-13T00:54:31Z Development Of Cisplatin Delivery Nanosystem With Chitosan-coated Titania Nanotube Arrays Platform Targeting For Nasopharyngeal Carcinoma 2022-06 Effendy, Wan Nuramiera Faznie Wan Eddis R5-920 Medicine (General) Present chemodrug treatment for advanced-stage nasopharyngeal carcinoma (NPC) via cisplatin (CDDP) have limitations such as non-specific biodistribution, dose-limiting toxicities, the emergence of resistant cancer cells and various side effects. Targeted and controlled release of CDDP delivery using titania nanotube arrays (TNA) smart nanosystem may offer a new approach to improve those limitations. TNA was fabricated, characterised, and optimised by electrochemical anodisation for CDDP loading in this study. The CDDP-loaded TNA (CDDP-TNA) encapsulation efficiency was studied using two methods: top-filling and immersion methods. The characterisation was performed using field emission scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, ion-coupled plasma–optical emission spectrometry, Fourier transform infrared spectroscopy, spectrophotometry and wettability test. Biopolymer chitosan-coated CDDP- TNAs were optimised in terms of concentrations of acetic acid for 10 mg/mL chitosan preparation, coating methods, number of coating layers, and biocompatibility of chitosan coating layers. The CDDP release activities from chitosan-coated CDDP-TNA were further investigated in various phosphate buffer saline immersion systems with different pH values, simulated body fluid, and targeted NPC in vitro system. Further intracellular observation was performed using fluorescence microscopy. 2022-06 Thesis http://eprints.usm.my/60152/ http://eprints.usm.my/60152/1/WAN%20NURAMIERA%20FAZNIE%20BT%20WAN%20EDDIS%20EFFENDY%20-%20TESIS24.pdf application/pdf en public masters Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-920 Medicine (General)
spellingShingle	R5-920 Medicine (General) Effendy, Wan Nuramiera Faznie Wan Eddis Development Of Cisplatin Delivery Nanosystem With Chitosan-coated Titania Nanotube Arrays Platform Targeting For Nasopharyngeal Carcinoma
description	Present chemodrug treatment for advanced-stage nasopharyngeal carcinoma (NPC) via cisplatin (CDDP) have limitations such as non-specific biodistribution, dose-limiting toxicities, the emergence of resistant cancer cells and various side effects. Targeted and controlled release of CDDP delivery using titania nanotube arrays (TNA) smart nanosystem may offer a new approach to improve those limitations. TNA was fabricated, characterised, and optimised by electrochemical anodisation for CDDP loading in this study. The CDDP-loaded TNA (CDDP-TNA) encapsulation efficiency was studied using two methods: top-filling and immersion methods. The characterisation was performed using field emission scanning electron microscopy, energy dispersive X-ray, X-ray diffraction, ion-coupled plasma–optical emission spectrometry, Fourier transform infrared spectroscopy, spectrophotometry and wettability test. Biopolymer chitosan-coated CDDP- TNAs were optimised in terms of concentrations of acetic acid for 10 mg/mL chitosan preparation, coating methods, number of coating layers, and biocompatibility of chitosan coating layers. The CDDP release activities from chitosan-coated CDDP-TNA were further investigated in various phosphate buffer saline immersion systems with different pH values, simulated body fluid, and targeted NPC in vitro system. Further intracellular observation was performed using fluorescence microscopy.
format	Thesis
qualification_level	Master's degree
author	Effendy, Wan Nuramiera Faznie Wan Eddis
author_facet	Effendy, Wan Nuramiera Faznie Wan Eddis
author_sort	Effendy, Wan Nuramiera Faznie Wan Eddis
title	Development Of Cisplatin Delivery Nanosystem With Chitosan-coated Titania Nanotube Arrays Platform Targeting For Nasopharyngeal Carcinoma
title_short	Development Of Cisplatin Delivery Nanosystem With Chitosan-coated Titania Nanotube Arrays Platform Targeting For Nasopharyngeal Carcinoma
title_full	Development Of Cisplatin Delivery Nanosystem With Chitosan-coated Titania Nanotube Arrays Platform Targeting For Nasopharyngeal Carcinoma
title_fullStr	Development Of Cisplatin Delivery Nanosystem With Chitosan-coated Titania Nanotube Arrays Platform Targeting For Nasopharyngeal Carcinoma
title_full_unstemmed	Development Of Cisplatin Delivery Nanosystem With Chitosan-coated Titania Nanotube Arrays Platform Targeting For Nasopharyngeal Carcinoma
title_sort	development of cisplatin delivery nanosystem with chitosan-coated titania nanotube arrays platform targeting for nasopharyngeal carcinoma
granting_institution	Universiti Sains Malaysia
granting_department	Institut Perubatan & Pergigian Termaju
publishDate	2022
url	http://eprints.usm.my/60152/1/WAN%20NURAMIERA%20FAZNIE%20BT%20WAN%20EDDIS%20EFFENDY%20-%20TESIS24.pdf
_version_	1794024096784187392

Development Of Cisplatin Delivery Nanosystem With Chitosan-coated Titania Nanotube Arrays Platform Targeting For Nasopharyngeal Carcinoma

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