Development Of A Flexible Stable Mammalian Antibody Expression Pipeline

Mammalian antibodies are promising tools for biopharmaceutical use because of their high specificity and low toxicity. These proteins are favorable for both therapeutic and diagnostic purposes and its ever-growing demand calls for high productivity cell lines. Mammalian cell lines can express antibo...

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Main Author:	Mark Kar Kei, Jacqueline
Format:	Thesis
Language:	English
Published:	2023
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/60199/1/Pages%20from%20JACQUELINE%20MARK%20KAR%20KEI%20-%20TESIS.pdf
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id	my-usm-ep.60199
record_format	uketd_dc
spelling	my-usm-ep.601992024-03-15T02:45:18Z Development Of A Flexible Stable Mammalian Antibody Expression Pipeline 2023-02 Mark Kar Kei, Jacqueline R5-920 Medicine (General) Mammalian antibodies are promising tools for biopharmaceutical use because of their high specificity and low toxicity. These proteins are favorable for both therapeutic and diagnostic purposes and its ever-growing demand calls for high productivity cell lines. Mammalian cell lines can express antibodies transiently or stably. Although the transient expression system has the benefits of rapid production, it is more suitable for short-term protein production and the initial phase of antibody testing. Meanwhile, a stable expression system is the go-to for long-term mass protein production because of its ability to express proteins in a reproducible, scalable, and reliable manner with no batch-to-batch variation. 2023-02 Thesis http://eprints.usm.my/60199/ http://eprints.usm.my/60199/1/Pages%20from%20JACQUELINE%20MARK%20KAR%20KEI%20-%20TESIS.pdf application/pdf en public masters Universiti Sains Malaysia Institut Penyelidikan Perubatan Molekul (Institute for Research in Molecular Medicine INFORMM)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-920 Medicine (General)
spellingShingle	R5-920 Medicine (General) Mark Kar Kei, Jacqueline Development Of A Flexible Stable Mammalian Antibody Expression Pipeline
description	Mammalian antibodies are promising tools for biopharmaceutical use because of their high specificity and low toxicity. These proteins are favorable for both therapeutic and diagnostic purposes and its ever-growing demand calls for high productivity cell lines. Mammalian cell lines can express antibodies transiently or stably. Although the transient expression system has the benefits of rapid production, it is more suitable for short-term protein production and the initial phase of antibody testing. Meanwhile, a stable expression system is the go-to for long-term mass protein production because of its ability to express proteins in a reproducible, scalable, and reliable manner with no batch-to-batch variation.
format	Thesis
qualification_level	Master's degree
author	Mark Kar Kei, Jacqueline
author_facet	Mark Kar Kei, Jacqueline
author_sort	Mark Kar Kei, Jacqueline
title	Development Of A Flexible Stable Mammalian Antibody Expression Pipeline
title_short	Development Of A Flexible Stable Mammalian Antibody Expression Pipeline
title_full	Development Of A Flexible Stable Mammalian Antibody Expression Pipeline
title_fullStr	Development Of A Flexible Stable Mammalian Antibody Expression Pipeline
title_full_unstemmed	Development Of A Flexible Stable Mammalian Antibody Expression Pipeline
title_sort	development of a flexible stable mammalian antibody expression pipeline
granting_institution	Universiti Sains Malaysia
granting_department	Institut Penyelidikan Perubatan Molekul (Institute for Research in Molecular Medicine INFORMM)
publishDate	2023
url	http://eprints.usm.my/60199/1/Pages%20from%20JACQUELINE%20MARK%20KAR%20KEI%20-%20TESIS.pdf
_version_	1794024104934768640

Development Of A Flexible Stable Mammalian Antibody Expression Pipeline

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