Radiation Dose Assessment Using 3D Quantitative Spect/Ct Imaging In Low Risk Differentiated Thyroid Cancer Patients

Radiation Dose Assessment Using 3D Quantitative Spect/Ct Imaging In Low Risk Differentiated Thyroid Cancer Patients

The prevalence of thyroid cancer continues to increase widely. Surgery, radioiodine therapy, chemotherapy, thyroid hormone therapy, and targeted therapy are all applicable options for the treatment of thyroid cancer, either alone or in combination. This study only include patients with low-risk thyr...

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Main Author: A Halim, Fatin Nadhirah
Format: Thesis
Language:English
Published: 2023
Subjects:
R5-920 Medicine (General)
Online Access:http://eprints.usm.my/60264/1/24%20Pages%20from%20FATIN%20NADHIRAH%20BINTI%20A%20HALIM.pdf
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spelling my-usm-ep.602642024-03-25T01:27:21Z Radiation Dose Assessment Using 3D Quantitative Spect/Ct Imaging In Low Risk Differentiated Thyroid Cancer Patients 2023-05 A Halim, Fatin Nadhirah R5-920 Medicine (General) The prevalence of thyroid cancer continues to increase widely. Surgery, radioiodine therapy, chemotherapy, thyroid hormone therapy, and targeted therapy are all applicable options for the treatment of thyroid cancer, either alone or in combination. This study only include patients with low-risk thyroid cancer of a specifically differentiated thyroid cancer type who have undergone total thyroidectomy (TT). These patients were referred to the Nuclear Medicine Department at Penang Hospital for radioactive iodine ablation therapy and received 2960 MBq to 3700 MBq of fixed administration activity. The utilisation of the fixed activity practice poses a challenge in assessing the extent to which the radioiodine activity would result in a lethal dose to normal organs or a tolerable dose that can be assimilated by the body. Based on the Medical Internal Radiation Dosimetry principle, the study's aim is to determine the individual radiation dose to the thyroid remnant and selected organs such as the liver, spleen, kidney, lung, and bone marrow. A quantitative three-dimensional (3D) technique was used to acquire the patient specific density map (from CT image) and activity map (from SPECT image) in conjunction with blood dosimetry utilising Single Positron Emission Computed Tomography in combination with Computed Tomography (SPECT/CT) imaging. Blood dosimetry was estimated using OLINDA, IDAC, and EANM technique. 2023-05 Thesis http://eprints.usm.my/60264/ http://eprints.usm.my/60264/1/24%20Pages%20from%20FATIN%20NADHIRAH%20BINTI%20A%20HALIM.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Institut Perubatan & Pergigian Termaju
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic R5-920 Medicine (General)
spellingShingle R5-920 Medicine (General)
A Halim, Fatin Nadhirah
Radiation Dose Assessment Using 3D Quantitative Spect/Ct Imaging In Low Risk Differentiated Thyroid Cancer Patients
description The prevalence of thyroid cancer continues to increase widely. Surgery, radioiodine therapy, chemotherapy, thyroid hormone therapy, and targeted therapy are all applicable options for the treatment of thyroid cancer, either alone or in combination. This study only include patients with low-risk thyroid cancer of a specifically differentiated thyroid cancer type who have undergone total thyroidectomy (TT). These patients were referred to the Nuclear Medicine Department at Penang Hospital for radioactive iodine ablation therapy and received 2960 MBq to 3700 MBq of fixed administration activity. The utilisation of the fixed activity practice poses a challenge in assessing the extent to which the radioiodine activity would result in a lethal dose to normal organs or a tolerable dose that can be assimilated by the body. Based on the Medical Internal Radiation Dosimetry principle, the study's aim is to determine the individual radiation dose to the thyroid remnant and selected organs such as the liver, spleen, kidney, lung, and bone marrow. A quantitative three-dimensional (3D) technique was used to acquire the patient specific density map (from CT image) and activity map (from SPECT image) in conjunction with blood dosimetry utilising Single Positron Emission Computed Tomography in combination with Computed Tomography (SPECT/CT) imaging. Blood dosimetry was estimated using OLINDA, IDAC, and EANM technique.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author A Halim, Fatin Nadhirah
author_facet A Halim, Fatin Nadhirah
author_sort A Halim, Fatin Nadhirah
title Radiation Dose Assessment Using 3D Quantitative Spect/Ct Imaging In Low Risk Differentiated Thyroid Cancer Patients
title_short Radiation Dose Assessment Using 3D Quantitative Spect/Ct Imaging In Low Risk Differentiated Thyroid Cancer Patients
title_full Radiation Dose Assessment Using 3D Quantitative Spect/Ct Imaging In Low Risk Differentiated Thyroid Cancer Patients
title_fullStr Radiation Dose Assessment Using 3D Quantitative Spect/Ct Imaging In Low Risk Differentiated Thyroid Cancer Patients
title_full_unstemmed Radiation Dose Assessment Using 3D Quantitative Spect/Ct Imaging In Low Risk Differentiated Thyroid Cancer Patients
title_sort radiation dose assessment using 3d quantitative spect/ct imaging in low risk differentiated thyroid cancer patients
granting_institution Perpustakaan Hamzah Sendut
granting_department Institut Perubatan & Pergigian Termaju
publishDate 2023
url http://eprints.usm.my/60264/1/24%20Pages%20from%20FATIN%20NADHIRAH%20BINTI%20A%20HALIM.pdf
_version_ 1804888901177835520

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