Defective Particle Surface On Zno And Its Influence On The Optical, Electronic And Toxicity Properties

Chemotherapy, radiation, and surgery are the most common treatments for cancer in recent years. Cancer is a disorder marked by uncontrolled malignant cell proliferation. Although in theory, all these treatments should be very successful at destroying cancer cells, nonselective therapeutic techniques...

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Main Author:	Kamaruddin, Nur Mariam
Format:	Thesis
Language:	English
Published:	2023
Subjects:	QC1 Physics (General)
Online Access:	http://eprints.usm.my/60266/1/NUR%20MARIAM%20BINTI%20KAMARUDDIN%20-%20TESIS%20cut.pdf
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spelling	my-usm-ep.602662024-03-25T03:45:36Z Defective Particle Surface On Zno And Its Influence On The Optical, Electronic And Toxicity Properties 2023-07 Kamaruddin, Nur Mariam QC1 Physics (General) Chemotherapy, radiation, and surgery are the most common treatments for cancer in recent years. Cancer is a disorder marked by uncontrolled malignant cell proliferation. Although in theory, all these treatments should be very successful at destroying cancer cells, nonselective therapeutic techniques nevertheless carry several major risks. Recent research has shown that zinc oxide (ZnO) has the potential to overcome these side effects due to its high biocompatibility, ease of surface functionalization, ability to target malignancy, and drug transport capability. These benefits allow ZnO to be chosen as biocompatible and biodegradable platforms, as well as being investigated for cancer treatment. The main objective of this study is to investigate how surface modification via various annealing ambient affects the properties of ZnO structures and how they relate to breast cancer cell survival (MCF-7). The morphological, structural, electrical, and optical properties of three ZnO (i) as grown (ZnO-AG), (ii) oxygen annealed (ZnO-O2) and (iii) nitrogen annealed (ZnO-N2) samples were investigated. The general morphologies of ZnO samples comprise rods, plates, tripod, and drumlike structures, as well as irregular shapes. The ZnO had a diameter of 30-200 nm while thickness 90-400 nm. Electron spectroscopy imaging (ESI) revealed oxygen and zinc atoms (O: Zn) distribution on the ZnO samples. On the ZnO surface, ZnO-O2 had a greater O:Zn ratio while ZnO-N2 had a lower O:Zn ratio. At 700oC, there was more oxygen adsorption on the ZnO-O2 surface whereas there was more oxygen desorption on the ZnO-N2 surface. Surface conductivity is reduced by ZnO-O2, whereas surface conductivity is increased by ZnO-N2. The highly polycrystalline properties of the ZnO sample were revealed by the XRD measurement. 2023-07 Thesis http://eprints.usm.my/60266/ http://eprints.usm.my/60266/1/NUR%20MARIAM%20BINTI%20KAMARUDDIN%20-%20TESIS%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Fizik
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QC1 Physics (General)
spellingShingle	QC1 Physics (General) Kamaruddin, Nur Mariam Defective Particle Surface On Zno And Its Influence On The Optical, Electronic And Toxicity Properties
description	Chemotherapy, radiation, and surgery are the most common treatments for cancer in recent years. Cancer is a disorder marked by uncontrolled malignant cell proliferation. Although in theory, all these treatments should be very successful at destroying cancer cells, nonselective therapeutic techniques nevertheless carry several major risks. Recent research has shown that zinc oxide (ZnO) has the potential to overcome these side effects due to its high biocompatibility, ease of surface functionalization, ability to target malignancy, and drug transport capability. These benefits allow ZnO to be chosen as biocompatible and biodegradable platforms, as well as being investigated for cancer treatment. The main objective of this study is to investigate how surface modification via various annealing ambient affects the properties of ZnO structures and how they relate to breast cancer cell survival (MCF-7). The morphological, structural, electrical, and optical properties of three ZnO (i) as grown (ZnO-AG), (ii) oxygen annealed (ZnO-O2) and (iii) nitrogen annealed (ZnO-N2) samples were investigated. The general morphologies of ZnO samples comprise rods, plates, tripod, and drumlike structures, as well as irregular shapes. The ZnO had a diameter of 30-200 nm while thickness 90-400 nm. Electron spectroscopy imaging (ESI) revealed oxygen and zinc atoms (O: Zn) distribution on the ZnO samples. On the ZnO surface, ZnO-O2 had a greater O:Zn ratio while ZnO-N2 had a lower O:Zn ratio. At 700oC, there was more oxygen adsorption on the ZnO-O2 surface whereas there was more oxygen desorption on the ZnO-N2 surface. Surface conductivity is reduced by ZnO-O2, whereas surface conductivity is increased by ZnO-N2. The highly polycrystalline properties of the ZnO sample were revealed by the XRD measurement.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Kamaruddin, Nur Mariam
author_facet	Kamaruddin, Nur Mariam
author_sort	Kamaruddin, Nur Mariam
title	Defective Particle Surface On Zno And Its Influence On The Optical, Electronic And Toxicity Properties
title_short	Defective Particle Surface On Zno And Its Influence On The Optical, Electronic And Toxicity Properties
title_full	Defective Particle Surface On Zno And Its Influence On The Optical, Electronic And Toxicity Properties
title_fullStr	Defective Particle Surface On Zno And Its Influence On The Optical, Electronic And Toxicity Properties
title_full_unstemmed	Defective Particle Surface On Zno And Its Influence On The Optical, Electronic And Toxicity Properties
title_sort	defective particle surface on zno and its influence on the optical, electronic and toxicity properties
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Fizik
publishDate	2023
url	http://eprints.usm.my/60266/1/NUR%20MARIAM%20BINTI%20KAMARUDDIN%20-%20TESIS%20cut.pdf
_version_	1804888901678006272

Defective Particle Surface On Zno And Its Influence On The Optical, Electronic And Toxicity Properties

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