Anti-candida And Microbiota Properties Of Breastmilk

Breast milk has been reported to exert a beneficial effect in countering a variety of infections that has been exposed to the mother during her life, because antibodies are transferred to breast milk via mammary glands, a branching epithelial structure, consisting of milk-transporting lactiferous du...

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Main Author:	Nisaa, Azka Ainun
Format:	Thesis
Language:	English
Published:	2023
Subjects:	T1-995 Technology(General)
Online Access:	http://eprints.usm.my/60314/1/AZKA%20AINUN%20NISAA%20-%20TESIS24.pdf
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id	my-usm-ep.60314
record_format	uketd_dc
spelling	my-usm-ep.603142024-04-01T03:26:47Z Anti-candida And Microbiota Properties Of Breastmilk 2023-08 Nisaa, Azka Ainun T1-995 Technology(General) Breast milk has been reported to exert a beneficial effect in countering a variety of infections that has been exposed to the mother during her life, because antibodies are transferred to breast milk via mammary glands, a branching epithelial structure, consisting of milk-transporting lactiferous ducts and alveoli. While vaginal infections may occur randomly in women, the Centers for Disease Control and Prevention (CDC) reported that pregnant women had a higher prevalence, which increased the risk of preterm and systemic infections in the newborn (CDC, 2022). Vaginal infections remain a major concern in obstetrics and gynecology because it has been shown that the mother's vaginal microbiota can pass directly to the baby after vaginal delivery. This study aimed to investigate the different immunological, antimicrobial properties and microbiota profiles of breast milk from women with (W) or without (WO) vaginal yeast infections during pregnancy in 85 lactating women (W, n= 43; WO, n= 42). Immuno-modulatory properties of breast milk which was determined by commercial enzyme-linked immunoabsorbent assay (ELISA) had shown that concentrations of IL-10, IgA, IgM, IgG, EGF, and TGF-α were similar in both groups. However, breast milk of women aged below 31 years old from the W-group showed higher concentration of EGF than the WO-group (p=0.031). Inhibitory activity of breast milk against vaginal Candida was performed via aggregation and growth inhibition of yeast cells. Breast milk from WO-group exhibited higher anti-Candida properties than W-group (p<0.001). 2023-08 Thesis http://eprints.usm.my/60314/ http://eprints.usm.my/60314/1/AZKA%20AINUN%20NISAA%20-%20TESIS24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Teknologi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	T1-995 Technology(General)
spellingShingle	T1-995 Technology(General) Nisaa, Azka Ainun Anti-candida And Microbiota Properties Of Breastmilk
description	Breast milk has been reported to exert a beneficial effect in countering a variety of infections that has been exposed to the mother during her life, because antibodies are transferred to breast milk via mammary glands, a branching epithelial structure, consisting of milk-transporting lactiferous ducts and alveoli. While vaginal infections may occur randomly in women, the Centers for Disease Control and Prevention (CDC) reported that pregnant women had a higher prevalence, which increased the risk of preterm and systemic infections in the newborn (CDC, 2022). Vaginal infections remain a major concern in obstetrics and gynecology because it has been shown that the mother's vaginal microbiota can pass directly to the baby after vaginal delivery. This study aimed to investigate the different immunological, antimicrobial properties and microbiota profiles of breast milk from women with (W) or without (WO) vaginal yeast infections during pregnancy in 85 lactating women (W, n= 43; WO, n= 42). Immuno-modulatory properties of breast milk which was determined by commercial enzyme-linked immunoabsorbent assay (ELISA) had shown that concentrations of IL-10, IgA, IgM, IgG, EGF, and TGF-α were similar in both groups. However, breast milk of women aged below 31 years old from the W-group showed higher concentration of EGF than the WO-group (p=0.031). Inhibitory activity of breast milk against vaginal Candida was performed via aggregation and growth inhibition of yeast cells. Breast milk from WO-group exhibited higher anti-Candida properties than W-group (p<0.001).
format	Thesis
qualification_level	Master's degree
author	Nisaa, Azka Ainun
author_facet	Nisaa, Azka Ainun
author_sort	Nisaa, Azka Ainun
title	Anti-candida And Microbiota Properties Of Breastmilk
title_short	Anti-candida And Microbiota Properties Of Breastmilk
title_full	Anti-candida And Microbiota Properties Of Breastmilk
title_fullStr	Anti-candida And Microbiota Properties Of Breastmilk
title_full_unstemmed	Anti-candida And Microbiota Properties Of Breastmilk
title_sort	anti-candida and microbiota properties of breastmilk
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Teknologi
publishDate	2023
url	http://eprints.usm.my/60314/1/AZKA%20AINUN%20NISAA%20-%20TESIS24.pdf
_version_	1804888910187200512

Anti-candida And Microbiota Properties Of Breastmilk

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