Binary And Ternary Complexes Of Β-Cyclodextrin With Isoniazid And Ethambutol: Characterization And Molecular Modeling Studies

Long term intake of antituberculosis drugs will lead to severe adverse reactions that will ultimately deteriorate a patient’s health and well-being. Presently, it is known that supramolecular macrocycles such as cyclodextrins (CDs) are useful to enhance drug solubility and targeting mechanism whi...

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Main Author:	Goh, Soen Qeng
Format:	Thesis
Language:	English
Published:	2023
Subjects:	QD1-999 Chemistry
Online Access:	http://eprints.usm.my/60388/1/GOH%20SOEN%20QENG%20-%20TESIS24.pdf
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id	my-usm-ep.60388
record_format	uketd_dc
spelling	my-usm-ep.603882024-04-18T03:10:50Z Binary And Ternary Complexes Of Β-Cyclodextrin With Isoniazid And Ethambutol: Characterization And Molecular Modeling Studies 2023-09 Goh, Soen Qeng QD1-999 Chemistry Long term intake of antituberculosis drugs will lead to severe adverse reactions that will ultimately deteriorate a patient’s health and well-being. Presently, it is known that supramolecular macrocycles such as cyclodextrins (CDs) are useful to enhance drug solubility and targeting mechanism while reducing drug dosage by providing many therapeutic benefits. With that, the possibility of formation of drug-CDs ternary inclusion complex was explored, whereby β-cyclodextrin (β-CD) was chosen as the supramolecular host carrier to accommodate two kinds of first-line antituberculosis guest drug molecules simultaneously, namely isoniazid (INH) and ethambutol (ETB). The inclusion complex of β-CD/INH/ETB was prepared using solvent evaporation method. Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (1H-NMR), and 2-dimensional nuclear Overhauser effect spectroscopy (2D-NOESY) NMR were used to investigate the functional groups and structure of the complex. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) were employed to study the surface morphology and crystallinity changes during complex formation. Thermogravimetric analysis (TGA) was performed to investigate the thermal properties of the complex. FT-IR and both types of NMR results had revealed the successful penetration of both the drug molecules into the β- CD cavity. SEM images and XRD spectra had shown a drastic change in surface structure and reduction in crystallinity during complex formation, which had indicated successful formation of a new compound. 2023-09 Thesis http://eprints.usm.my/60388/ http://eprints.usm.my/60388/1/GOH%20SOEN%20QENG%20-%20TESIS24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QD1-999 Chemistry
spellingShingle	QD1-999 Chemistry Goh, Soen Qeng Binary And Ternary Complexes Of Β-Cyclodextrin With Isoniazid And Ethambutol: Characterization And Molecular Modeling Studies
description	Long term intake of antituberculosis drugs will lead to severe adverse reactions that will ultimately deteriorate a patient’s health and well-being. Presently, it is known that supramolecular macrocycles such as cyclodextrins (CDs) are useful to enhance drug solubility and targeting mechanism while reducing drug dosage by providing many therapeutic benefits. With that, the possibility of formation of drug-CDs ternary inclusion complex was explored, whereby β-cyclodextrin (β-CD) was chosen as the supramolecular host carrier to accommodate two kinds of first-line antituberculosis guest drug molecules simultaneously, namely isoniazid (INH) and ethambutol (ETB). The inclusion complex of β-CD/INH/ETB was prepared using solvent evaporation method. Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (1H-NMR), and 2-dimensional nuclear Overhauser effect spectroscopy (2D-NOESY) NMR were used to investigate the functional groups and structure of the complex. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) were employed to study the surface morphology and crystallinity changes during complex formation. Thermogravimetric analysis (TGA) was performed to investigate the thermal properties of the complex. FT-IR and both types of NMR results had revealed the successful penetration of both the drug molecules into the β- CD cavity. SEM images and XRD spectra had shown a drastic change in surface structure and reduction in crystallinity during complex formation, which had indicated successful formation of a new compound.
format	Thesis
qualification_level	Master's degree
author	Goh, Soen Qeng
author_facet	Goh, Soen Qeng
author_sort	Goh, Soen Qeng
title	Binary And Ternary Complexes Of Β-Cyclodextrin With Isoniazid And Ethambutol: Characterization And Molecular Modeling Studies
title_short	Binary And Ternary Complexes Of Β-Cyclodextrin With Isoniazid And Ethambutol: Characterization And Molecular Modeling Studies
title_full	Binary And Ternary Complexes Of Β-Cyclodextrin With Isoniazid And Ethambutol: Characterization And Molecular Modeling Studies
title_fullStr	Binary And Ternary Complexes Of Β-Cyclodextrin With Isoniazid And Ethambutol: Characterization And Molecular Modeling Studies
title_full_unstemmed	Binary And Ternary Complexes Of Β-Cyclodextrin With Isoniazid And Ethambutol: Characterization And Molecular Modeling Studies
title_sort	binary and ternary complexes of β-cyclodextrin with isoniazid and ethambutol: characterization and molecular modeling studies
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kimia
publishDate	2023
url	http://eprints.usm.my/60388/1/GOH%20SOEN%20QENG%20-%20TESIS24.pdf
_version_	1804888927880871936

Binary And Ternary Complexes Of Β-Cyclodextrin With Isoniazid And Ethambutol: Characterization And Molecular Modeling Studies

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