Synthesis, Characterization, Cytotoxicity, And Antimicrobial Activity Of Azobenzene-Imidazolium Ionic Liquid Crystals

Synthesis, Characterization, Cytotoxicity, And Antimicrobial Activity Of Azobenzene-Imidazolium Ionic Liquid Crystals

Four new series of azobenzene-imidazolium salts were synthesized by azo coupling, followed by alkylation and subsequent quaternization of N-alkylated imidazoles of various chain length with azobenzenes to afford the non-fluorinated (9a-9e), difluorinated (10a-10e) and tetrafluorinated (11a-11e, 12a-...

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Main Author: Funmilayo, Babamale Halimah
Format: Thesis
Language:English
Published: 2023
Subjects:
QD1-999 Chemistry
Online Access:http://eprints.usm.my/60431/1/Pages%20from%20HALIMAH%20FUNMILAYO%20BABAMALE%20-%20TESIS.pdf
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spelling my-usm-ep.604312024-04-26T07:15:40Z Synthesis, Characterization, Cytotoxicity, And Antimicrobial Activity Of Azobenzene-Imidazolium Ionic Liquid Crystals 2023-04 Funmilayo, Babamale Halimah QD1-999 Chemistry Four new series of azobenzene-imidazolium salts were synthesized by azo coupling, followed by alkylation and subsequent quaternization of N-alkylated imidazoles of various chain length with azobenzenes to afford the non-fluorinated (9a-9e), difluorinated (10a-10e) and tetrafluorinated (11a-11e, 12a-12j) salts. The purity of the compounds was confirmed by CHN elemental analysis and their structures were elucidated using the FTIR, 1D and 2D NMR spectroscopies. The liquid crystalline (LC) properties of the salts were studied using the DSC and POM. In vitro cytotoxicity was explored using the MTT assay and their antimicrobial activities were investigated using the disc diffusion method. Smectic A (SmA) phase was observed in almost all compounds. 2023-04 Thesis http://eprints.usm.my/60431/ http://eprints.usm.my/60431/1/Pages%20from%20HALIMAH%20FUNMILAYO%20BABAMALE%20-%20TESIS.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kimia ( School of Chemical Sciences)
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic QD1-999 Chemistry
spellingShingle QD1-999 Chemistry
Funmilayo, Babamale Halimah
Synthesis, Characterization, Cytotoxicity, And Antimicrobial Activity Of Azobenzene-Imidazolium Ionic Liquid Crystals
description Four new series of azobenzene-imidazolium salts were synthesized by azo coupling, followed by alkylation and subsequent quaternization of N-alkylated imidazoles of various chain length with azobenzenes to afford the non-fluorinated (9a-9e), difluorinated (10a-10e) and tetrafluorinated (11a-11e, 12a-12j) salts. The purity of the compounds was confirmed by CHN elemental analysis and their structures were elucidated using the FTIR, 1D and 2D NMR spectroscopies. The liquid crystalline (LC) properties of the salts were studied using the DSC and POM. In vitro cytotoxicity was explored using the MTT assay and their antimicrobial activities were investigated using the disc diffusion method. Smectic A (SmA) phase was observed in almost all compounds.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Funmilayo, Babamale Halimah
author_facet Funmilayo, Babamale Halimah
author_sort Funmilayo, Babamale Halimah
title Synthesis, Characterization, Cytotoxicity, And Antimicrobial Activity Of Azobenzene-Imidazolium Ionic Liquid Crystals
title_short Synthesis, Characterization, Cytotoxicity, And Antimicrobial Activity Of Azobenzene-Imidazolium Ionic Liquid Crystals
title_full Synthesis, Characterization, Cytotoxicity, And Antimicrobial Activity Of Azobenzene-Imidazolium Ionic Liquid Crystals
title_fullStr Synthesis, Characterization, Cytotoxicity, And Antimicrobial Activity Of Azobenzene-Imidazolium Ionic Liquid Crystals
title_full_unstemmed Synthesis, Characterization, Cytotoxicity, And Antimicrobial Activity Of Azobenzene-Imidazolium Ionic Liquid Crystals
title_sort synthesis, characterization, cytotoxicity, and antimicrobial activity of azobenzene-imidazolium ionic liquid crystals
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Kimia ( School of Chemical Sciences)
publishDate 2023
url http://eprints.usm.my/60431/1/Pages%20from%20HALIMAH%20FUNMILAYO%20BABAMALE%20-%20TESIS.pdf
_version_ 1804888935659208704

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