Comparison of high resolution computed tomography findings of thorax between smear negative pulmonary tuberculosis and non-pulmonary tuberculosis among patients with suspected pulmonary tuberculosis in Hospital Universiti Sains Malaysia

Background: Pulmonary tuberculosis (PTB) has been around for over 100 years since it was first discovered. Despite its long existence, medical practitioners still found it challenging to diagnose sputum smear negative PTB. The ability of high resolution computed tomography (HRCT) in diagnosing PT...

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Main Author:	Chong, Yap Teck
Format:	Thesis
Language:	English
Published:	2022
Subjects:	R Medicine RC306-320.5 Tuberculosis
Online Access:	http://eprints.usm.my/60463/1/Yap%20Teck%20Chong-E.pdf
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id	my-usm-ep.60463
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spelling	my-usm-ep.604632024-05-05T07:57:33Z Comparison of high resolution computed tomography findings of thorax between smear negative pulmonary tuberculosis and non-pulmonary tuberculosis among patients with suspected pulmonary tuberculosis in Hospital Universiti Sains Malaysia 2022 Chong, Yap Teck R Medicine RA440-440.87 Study and teaching. Research RC306-320.5 Tuberculosis Background: Pulmonary tuberculosis (PTB) has been around for over 100 years since it was first discovered. Despite its long existence, medical practitioners still found it challenging to diagnose sputum smear negative PTB. The ability of high resolution computed tomography (HRCT) in diagnosing PTB is still under discussion and investigation in the sputum smear-negative setting. Thus, this study was conducted to determine the HRCT findings in diagnosing early stage of active smear negative PTB and to study specific HRCT findings in diagnosing smear negative PTB. Methods: A cross-sectional study was conducted in Hospital Universiti Sains Malaysia (USM), Kota Bharu, Kelantan, Malaysia on 22 patients whose sputum smears were negative, and had undergone HRCT thorax. HRCT findings were collected and described using descriptive statistic, count (n) and percentage (%); and comparative HRCT findings between smear negative PTB versus non-PTB was analysed using the Pearson chi-square test. Results: The tree-in-bud appearance showed a significant association with smear negative PTB, with p-value of 0.046. And this main findings of tree-in-bud appearance showed significant association with smear negative PTB at S5 (medial segment) of right middle lobe and S3 (anterior segment) of left upper lobe, with p-value of 0.025 on both sides. Conclusion: Tree-in-bud appearance which indicates the early stage of active PTB, had shown significant association with smear negative PTB, and can be detected in HRCT. Hence, HRCT could be used as an alternative method to detect active PTB in the background of sputum smear-negative setting among higher risk patients. 2022 Thesis http://eprints.usm.my/60463/ http://eprints.usm.my/60463/1/Yap%20Teck%20Chong-E.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine R Medicine RC306-320.5 Tuberculosis
spellingShingle	R Medicine R Medicine RC306-320.5 Tuberculosis Chong, Yap Teck Comparison of high resolution computed tomography findings of thorax between smear negative pulmonary tuberculosis and non-pulmonary tuberculosis among patients with suspected pulmonary tuberculosis in Hospital Universiti Sains Malaysia
description	Background: Pulmonary tuberculosis (PTB) has been around for over 100 years since it was first discovered. Despite its long existence, medical practitioners still found it challenging to diagnose sputum smear negative PTB. The ability of high resolution computed tomography (HRCT) in diagnosing PTB is still under discussion and investigation in the sputum smear-negative setting. Thus, this study was conducted to determine the HRCT findings in diagnosing early stage of active smear negative PTB and to study specific HRCT findings in diagnosing smear negative PTB. Methods: A cross-sectional study was conducted in Hospital Universiti Sains Malaysia (USM), Kota Bharu, Kelantan, Malaysia on 22 patients whose sputum smears were negative, and had undergone HRCT thorax. HRCT findings were collected and described using descriptive statistic, count (n) and percentage (%); and comparative HRCT findings between smear negative PTB versus non-PTB was analysed using the Pearson chi-square test. Results: The tree-in-bud appearance showed a significant association with smear negative PTB, with p-value of 0.046. And this main findings of tree-in-bud appearance showed significant association with smear negative PTB at S5 (medial segment) of right middle lobe and S3 (anterior segment) of left upper lobe, with p-value of 0.025 on both sides. Conclusion: Tree-in-bud appearance which indicates the early stage of active PTB, had shown significant association with smear negative PTB, and can be detected in HRCT. Hence, HRCT could be used as an alternative method to detect active PTB in the background of sputum smear-negative setting among higher risk patients.
format	Thesis
qualification_level	Master's degree
author	Chong, Yap Teck
author_facet	Chong, Yap Teck
author_sort	Chong, Yap Teck
title	Comparison of high resolution computed tomography findings of thorax between smear negative pulmonary tuberculosis and non-pulmonary tuberculosis among patients with suspected pulmonary tuberculosis in Hospital Universiti Sains Malaysia
title_short	Comparison of high resolution computed tomography findings of thorax between smear negative pulmonary tuberculosis and non-pulmonary tuberculosis among patients with suspected pulmonary tuberculosis in Hospital Universiti Sains Malaysia
title_full	Comparison of high resolution computed tomography findings of thorax between smear negative pulmonary tuberculosis and non-pulmonary tuberculosis among patients with suspected pulmonary tuberculosis in Hospital Universiti Sains Malaysia
title_fullStr	Comparison of high resolution computed tomography findings of thorax between smear negative pulmonary tuberculosis and non-pulmonary tuberculosis among patients with suspected pulmonary tuberculosis in Hospital Universiti Sains Malaysia
title_full_unstemmed	Comparison of high resolution computed tomography findings of thorax between smear negative pulmonary tuberculosis and non-pulmonary tuberculosis among patients with suspected pulmonary tuberculosis in Hospital Universiti Sains Malaysia
title_sort	comparison of high resolution computed tomography findings of thorax between smear negative pulmonary tuberculosis and non-pulmonary tuberculosis among patients with suspected pulmonary tuberculosis in hospital universiti sains malaysia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2022
url	http://eprints.usm.my/60463/1/Yap%20Teck%20Chong-E.pdf
_version_	1804888942633287680

Comparison of high resolution computed tomography findings of thorax between smear negative pulmonary tuberculosis and non-pulmonary tuberculosis among patients with suspected pulmonary tuberculosis in Hospital Universiti Sains Malaysia

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