Characterisation And Formulation Of Topical Methyl Salicylate Patches: Effect Of Solvents On Adhesion And Drug Permeation

Topical methyl salicylate (MS) patch is popular for pain management. The skin permeation profile of MS is important for formulation design but limited studies were conducted. This project aims to investigate the effect of solvents on the characteristics of patches, drug release and permeation of MS....

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Main Author: Yeoh, Soo Chin
Format: Thesis
Language:English
Published: 2023
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Online Access:http://eprints.usm.my/60572/1/YEOH%20SOO%20CHIN%20-%20TESIS%20cut.pdf
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spelling my-usm-ep.605722024-05-07T07:01:38Z Characterisation And Formulation Of Topical Methyl Salicylate Patches: Effect Of Solvents On Adhesion And Drug Permeation 2023-01 Yeoh, Soo Chin RS1-441 Pharmacy and materia medica Topical methyl salicylate (MS) patch is popular for pain management. The skin permeation profile of MS is important for formulation design but limited studies were conducted. This project aims to investigate the effect of solvents on the characteristics of patches, drug release and permeation of MS. In this project, suitable solvents were first selected for the patch formulation. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy was utilised to scan the stratum corneum (SC) sheets treated with solvents and MS. Next, in vitro permeation studies were carried out with 10%v/v of MS in solvents. After that, patches containing 5%w/w of solvents and/or 10%w/w of MS were prepared with Durabond PC 1879A (8%w/w), Nikasol TS-620 (7%w/w), carboxymethyl cellulose (3.5%w/w) and polyvinyl pyrrolidone (3%w/w). Next, the patches formed were subjected to physiochemical characterisation tests, including ATR-FTIR spectroscopy, tackiness test using stainless-steel probe, peel strength test with porcine ear skin, swelling test, in vitro drug release and skin permeation studies. In in vitro permeation studies, MS in propylene glycol (PG) in drug solution displayed the highest skin permeation of MS and followed by Plurol® oleique (PLU), Labrasol® (LA), Transcutol® (TRC), Maisine® (MAI) and isopropyl myristate (IPM) at 24 h. 2023-01 Thesis http://eprints.usm.my/60572/ http://eprints.usm.my/60572/1/YEOH%20SOO%20CHIN%20-%20TESIS%20cut.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Yeoh, Soo Chin
Characterisation And Formulation Of Topical Methyl Salicylate Patches: Effect Of Solvents On Adhesion And Drug Permeation
description Topical methyl salicylate (MS) patch is popular for pain management. The skin permeation profile of MS is important for formulation design but limited studies were conducted. This project aims to investigate the effect of solvents on the characteristics of patches, drug release and permeation of MS. In this project, suitable solvents were first selected for the patch formulation. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy was utilised to scan the stratum corneum (SC) sheets treated with solvents and MS. Next, in vitro permeation studies were carried out with 10%v/v of MS in solvents. After that, patches containing 5%w/w of solvents and/or 10%w/w of MS were prepared with Durabond PC 1879A (8%w/w), Nikasol TS-620 (7%w/w), carboxymethyl cellulose (3.5%w/w) and polyvinyl pyrrolidone (3%w/w). Next, the patches formed were subjected to physiochemical characterisation tests, including ATR-FTIR spectroscopy, tackiness test using stainless-steel probe, peel strength test with porcine ear skin, swelling test, in vitro drug release and skin permeation studies. In in vitro permeation studies, MS in propylene glycol (PG) in drug solution displayed the highest skin permeation of MS and followed by Plurol® oleique (PLU), Labrasol® (LA), Transcutol® (TRC), Maisine® (MAI) and isopropyl myristate (IPM) at 24 h.
format Thesis
qualification_level Master's degree
author Yeoh, Soo Chin
author_facet Yeoh, Soo Chin
author_sort Yeoh, Soo Chin
title Characterisation And Formulation Of Topical Methyl Salicylate Patches: Effect Of Solvents On Adhesion And Drug Permeation
title_short Characterisation And Formulation Of Topical Methyl Salicylate Patches: Effect Of Solvents On Adhesion And Drug Permeation
title_full Characterisation And Formulation Of Topical Methyl Salicylate Patches: Effect Of Solvents On Adhesion And Drug Permeation
title_fullStr Characterisation And Formulation Of Topical Methyl Salicylate Patches: Effect Of Solvents On Adhesion And Drug Permeation
title_full_unstemmed Characterisation And Formulation Of Topical Methyl Salicylate Patches: Effect Of Solvents On Adhesion And Drug Permeation
title_sort characterisation and formulation of topical methyl salicylate patches: effect of solvents on adhesion and drug permeation
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Farmasi
publishDate 2023
url http://eprints.usm.my/60572/1/YEOH%20SOO%20CHIN%20-%20TESIS%20cut.pdf
_version_ 1804888965592907776