The Role Of Vitamin E In Reducing Bone Cancer Pain In Rat Model Of Breast Cancer-Induced Bone Pain

The Role Of Vitamin E In Reducing Bone Cancer Pain In Rat Model Of Breast Cancer-Induced Bone Pain

Cancer-induced bone pain is currently facing inadequate pain management considering the unwanted side effects, relative ineffectiveness and suitability of medicine. The pain resulted from primary cancer that metastasized to bone comes with complicated mechanisms involving inflammatory and neuropathi...

Full description

Saved in:
Bibliographic Details
Main Author: Baharuddin, Nur Saeida
Format: Thesis
Language:English
Published: 2023
Subjects:
QH301 Biology
Online Access:http://eprints.usm.my/60575/1/NUR%20SAEIDA%20BINTI%20BAHARUDDIN%20-%20TESIS%20cut.pdf
Tags: Add Tag
No Tags, Be the first to tag this record!
id my-usm-ep.60575
record_format uketd_dc
spelling my-usm-ep.605752024-05-07T07:52:10Z The Role Of Vitamin E In Reducing Bone Cancer Pain In Rat Model Of Breast Cancer-Induced Bone Pain 2023-01 Baharuddin, Nur Saeida QH301 Biology Cancer-induced bone pain is currently facing inadequate pain management considering the unwanted side effects, relative ineffectiveness and suitability of medicine. The pain resulted from primary cancer that metastasized to bone comes with complicated mechanisms involving inflammatory and neuropathic pathway causing skeletal-related complications such as pathological bone fractures, nerve root compression and hypercalcemia of malignancy. Search for therapeutics alternative options to reduce pain and target few mechanism pathways could improve the overall survival for metastatic patients. Vitamin E as an antioxidant is widely published in bone health, anti-inflammatory, anti-cancer and anti-metastatic properties, thereby potentiate its ability in targeting cancer-induced bone pain. This study aimed to evaluate the role of vitamin E in reducing bone cancer pain in female rat model of breast cancer-induced bone pain. The rats were randomly divided into five groups of ten rats according to the experimental design. Breast cancer cell line, MDA-MB-231 at a concentration of 1 x 106 were induced into left femur of four groups namely Negative Control (NC), Alpha tocopherol (ATF), Tocotrienol Rich Fraction (TRF) and Zoledronic Acid (ZA) whereas Sham (SH) group was injected with culture media only. The rats were orally supplemented daily with 60 mg/kg alpha tocopherol for ATF group, 60 mg/kg Tocotrienol Rich Fraction for TRF group, and olive oil that serves as vehicle to SH and NC groups for 21 days. Whereas, the ZA group was dosed with 0.1 mg/kg Zoledronic Acid weekly. 2023-01 Thesis http://eprints.usm.my/60575/ http://eprints.usm.my/60575/1/NUR%20SAEIDA%20BINTI%20BAHARUDDIN%20-%20TESIS%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Institut Perubatan & Pergigian Termaju
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic QH301 Biology
spellingShingle QH301 Biology
Baharuddin, Nur Saeida
The Role Of Vitamin E In Reducing Bone Cancer Pain In Rat Model Of Breast Cancer-Induced Bone Pain
description Cancer-induced bone pain is currently facing inadequate pain management considering the unwanted side effects, relative ineffectiveness and suitability of medicine. The pain resulted from primary cancer that metastasized to bone comes with complicated mechanisms involving inflammatory and neuropathic pathway causing skeletal-related complications such as pathological bone fractures, nerve root compression and hypercalcemia of malignancy. Search for therapeutics alternative options to reduce pain and target few mechanism pathways could improve the overall survival for metastatic patients. Vitamin E as an antioxidant is widely published in bone health, anti-inflammatory, anti-cancer and anti-metastatic properties, thereby potentiate its ability in targeting cancer-induced bone pain. This study aimed to evaluate the role of vitamin E in reducing bone cancer pain in female rat model of breast cancer-induced bone pain. The rats were randomly divided into five groups of ten rats according to the experimental design. Breast cancer cell line, MDA-MB-231 at a concentration of 1 x 106 were induced into left femur of four groups namely Negative Control (NC), Alpha tocopherol (ATF), Tocotrienol Rich Fraction (TRF) and Zoledronic Acid (ZA) whereas Sham (SH) group was injected with culture media only. The rats were orally supplemented daily with 60 mg/kg alpha tocopherol for ATF group, 60 mg/kg Tocotrienol Rich Fraction for TRF group, and olive oil that serves as vehicle to SH and NC groups for 21 days. Whereas, the ZA group was dosed with 0.1 mg/kg Zoledronic Acid weekly.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Baharuddin, Nur Saeida
author_facet Baharuddin, Nur Saeida
author_sort Baharuddin, Nur Saeida
title The Role Of Vitamin E In Reducing Bone Cancer Pain In Rat Model Of Breast Cancer-Induced Bone Pain
title_short The Role Of Vitamin E In Reducing Bone Cancer Pain In Rat Model Of Breast Cancer-Induced Bone Pain
title_full The Role Of Vitamin E In Reducing Bone Cancer Pain In Rat Model Of Breast Cancer-Induced Bone Pain
title_fullStr The Role Of Vitamin E In Reducing Bone Cancer Pain In Rat Model Of Breast Cancer-Induced Bone Pain
title_full_unstemmed The Role Of Vitamin E In Reducing Bone Cancer Pain In Rat Model Of Breast Cancer-Induced Bone Pain
title_sort role of vitamin e in reducing bone cancer pain in rat model of breast cancer-induced bone pain
granting_institution Universiti Sains Malaysia
granting_department Institut Perubatan & Pergigian Termaju
publishDate 2023
url http://eprints.usm.my/60575/1/NUR%20SAEIDA%20BINTI%20BAHARUDDIN%20-%20TESIS%20cut.pdf
_version_ 1804888966343688192

Similar Items