Diagnostic value of serum and tissue eosinophil in diagnosis of asthma among patients with chronic rhinosinusitis

Background: Chronic rhinosinusitis (CRS) is one of the most common chronic inflammatory diseases of sinonasal mucosa. Asthma among CRS patients is often underdiagnosed and causes management of CRS more challenging. Therefore, using serum and tissue eosinophil as an indicator and prediction of ast...

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Main Author:	Mat, Che Mohd Hilmi Che
Format:	Thesis
Language:	English
Published:	2022
Subjects:	R Medicine RC Internal medicine
Online Access:	http://eprints.usm.my/60645/1/Che%20Mohd%20Hilmi%20Che%20Mat-E.pdf
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spelling	my-usm-ep.606452024-07-15T07:12:18Z Diagnostic value of serum and tissue eosinophil in diagnosis of asthma among patients with chronic rhinosinusitis 2022 Mat, Che Mohd Hilmi Che R Medicine RC Internal medicine Background: Chronic rhinosinusitis (CRS) is one of the most common chronic inflammatory diseases of sinonasal mucosa. Asthma among CRS patients is often underdiagnosed and causes management of CRS more challenging. Therefore, using serum and tissue eosinophil as an indicator and prediction of asthma in CRS patients are valuable for further preventing recurrent and increase the effectiveness of treatment for CRS. Objective: To determine the association and diagnostic ability of serum and tissue eosinophils in the diagnosis of asthma among CRS patients. Method: A cross-sectional study was conducted involving 24 CRS patients with and without asthma respectively from the Otorhinolaryngology clinic of two tertiary hospitals located in the East Coast of Peninsular Malaysia. Serum and tissue eosinophils (obtained from nasal polyp) between both groups were compared. Association between serum and tissue eosinophils with asthma evaluated using logistic regression analysis, adjusting for important sociodemographic characteristics. The diagnostic ability of serum and tissue eosinophil was then evaluated by assessing the receiver operating characteristic (ROC) curve. Results: A total of 48 CRS patients with a mean [SD] age of 47.50 [14.99] years were included. Patients with asthma had significantly higher serum [0.48 vs 0.35 x109/L] and tissue eosinophil [100 vs 8.5 per HPF]. Tissue eosinophils were found to be an independent predictor of asthma with adjusted OR=1.05, p<0.001, after adjusting for age and serum eosinophils. The area under the ROC curve for serum eosinophil was 69.0%. At optimal cutoff value (0.375 x109/L), the sensitivity and specificity for serum eosinophil was 75.0% and 70.8%. The area under the ROC curve for tissue eosinophil was 93.4%. At optimal cut-off value (58.0 per HPF), the sensitivity and specificity for tissue eosinophil were 79.2% and 91.7% respectively. Conclusion: A significantly higher level of serum and tissue eosinophil are seen in CRS with asthma. However, there was no correlation between serum and tissue eosinophil in both groups. The CRS patient needs to be screened for asthma if the level of serum eosinophil is more than 0.375 x 109/L and tissue eosinophil more than 58 per HPF. 2022 Thesis http://eprints.usm.my/60645/ http://eprints.usm.my/60645/1/Che%20Mohd%20Hilmi%20Che%20Mat-E.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine RC Internal medicine
spellingShingle	R Medicine RC Internal medicine Mat, Che Mohd Hilmi Che Diagnostic value of serum and tissue eosinophil in diagnosis of asthma among patients with chronic rhinosinusitis
description	Background: Chronic rhinosinusitis (CRS) is one of the most common chronic inflammatory diseases of sinonasal mucosa. Asthma among CRS patients is often underdiagnosed and causes management of CRS more challenging. Therefore, using serum and tissue eosinophil as an indicator and prediction of asthma in CRS patients are valuable for further preventing recurrent and increase the effectiveness of treatment for CRS. Objective: To determine the association and diagnostic ability of serum and tissue eosinophils in the diagnosis of asthma among CRS patients. Method: A cross-sectional study was conducted involving 24 CRS patients with and without asthma respectively from the Otorhinolaryngology clinic of two tertiary hospitals located in the East Coast of Peninsular Malaysia. Serum and tissue eosinophils (obtained from nasal polyp) between both groups were compared. Association between serum and tissue eosinophils with asthma evaluated using logistic regression analysis, adjusting for important sociodemographic characteristics. The diagnostic ability of serum and tissue eosinophil was then evaluated by assessing the receiver operating characteristic (ROC) curve. Results: A total of 48 CRS patients with a mean [SD] age of 47.50 [14.99] years were included. Patients with asthma had significantly higher serum [0.48 vs 0.35 x109/L] and tissue eosinophil [100 vs 8.5 per HPF]. Tissue eosinophils were found to be an independent predictor of asthma with adjusted OR=1.05, p<0.001, after adjusting for age and serum eosinophils. The area under the ROC curve for serum eosinophil was 69.0%. At optimal cutoff value (0.375 x109/L), the sensitivity and specificity for serum eosinophil was 75.0% and 70.8%. The area under the ROC curve for tissue eosinophil was 93.4%. At optimal cut-off value (58.0 per HPF), the sensitivity and specificity for tissue eosinophil were 79.2% and 91.7% respectively. Conclusion: A significantly higher level of serum and tissue eosinophil are seen in CRS with asthma. However, there was no correlation between serum and tissue eosinophil in both groups. The CRS patient needs to be screened for asthma if the level of serum eosinophil is more than 0.375 x 109/L and tissue eosinophil more than 58 per HPF.
format	Thesis
qualification_level	Master's degree
author	Mat, Che Mohd Hilmi Che
author_facet	Mat, Che Mohd Hilmi Che
author_sort	Mat, Che Mohd Hilmi Che
title	Diagnostic value of serum and tissue eosinophil in diagnosis of asthma among patients with chronic rhinosinusitis
title_short	Diagnostic value of serum and tissue eosinophil in diagnosis of asthma among patients with chronic rhinosinusitis
title_full	Diagnostic value of serum and tissue eosinophil in diagnosis of asthma among patients with chronic rhinosinusitis
title_fullStr	Diagnostic value of serum and tissue eosinophil in diagnosis of asthma among patients with chronic rhinosinusitis
title_full_unstemmed	Diagnostic value of serum and tissue eosinophil in diagnosis of asthma among patients with chronic rhinosinusitis
title_sort	diagnostic value of serum and tissue eosinophil in diagnosis of asthma among patients with chronic rhinosinusitis
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2022
url	http://eprints.usm.my/60645/1/Che%20Mohd%20Hilmi%20Che%20Mat-E.pdf
_version_	1804888978685427712

Diagnostic value of serum and tissue eosinophil in diagnosis of asthma among patients with chronic rhinosinusitis

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