Development And Characterization Of Polymer Gel Dosimeter Doped With Gold Nanoparticles

This study makes use of the advantage of normoxic polymer gels which are composed of two different monomer, 2-Hydroxyethyl Acrylate (HEA) and 2-Hydroxyethyl Methacrylate (HEMA) and N,N’-Methylene-bisacrylamide (BIS) as the crosslinker. To enable the fabrication of polymer gel to be done under the no...

Full description

Saved in:

Bibliographic Details
Main Author:	Hisham, Muhd Hazwan Hakim
Format:	Thesis
Language:	English
Published:	2023
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/60648/1/MUHD%20HAZWAN%20HAKIM%20BIN%20HISHAM%20-%20TESIS24.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.60648
record_format	uketd_dc
spelling	my-usm-ep.606482024-05-17T07:51:35Z Development And Characterization Of Polymer Gel Dosimeter Doped With Gold Nanoparticles 2023-08 Hisham, Muhd Hazwan Hakim RS1-441 Pharmacy and materia medica This study makes use of the advantage of normoxic polymer gels which are composed of two different monomer, 2-Hydroxyethyl Acrylate (HEA) and 2-Hydroxyethyl Methacrylate (HEMA) and N,N’-Methylene-bisacrylamide (BIS) as the crosslinker. To enable the fabrication of polymer gel to be done under the normal atmospheric condition, Ascorbic Acid is added as the anti-oxidant. As past studies had mainly been done using high energy sources, this study also focuses on using high energy x-ray source as in linear accelerator (LINAC) as well as a diagnostic x-ray unit as the main energy source. Dose sensitivity is property investigated in studying the behavior of dose distribution in the polymer gel. Magnetic Resonance Imaging (MRI) is the main polymerization imaging readout instrument before the images are used for further calculation of dose sensitivity. The results obtained are backed up by the analysis using UV-Visible spectrophotometer. In general, the dose sensitivity is directly proportional to the irradiation energy, monomer concentration and AuNPs size. When HEMA is used as the monomer, higher irradiation dose by LINAC increases the absorption of light. This is true for all the size of AuNPs used in this study (15nm, 20 nm, 40nm, 50nm and 80nm). Except for 50nm AuNP size, samples irradiated with dose of 30Gy shows a decreasing absorption of light at wavelength over 500nm. The decreasing pattern goes below than the samples irradiated with 10Gy and 20Gy. The result shows that at low x-ray energy, the size of AuNP has an impact on the polymerization. Higher concentration of monomer does not affect the polymerization significantly at the low energy level. At high x-ray energy 2023-08 Thesis http://eprints.usm.my/60648/ http://eprints.usm.my/60648/1/MUHD%20HAZWAN%20HAKIM%20BIN%20HISHAM%20-%20TESIS24.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Hisham, Muhd Hazwan Hakim Development And Characterization Of Polymer Gel Dosimeter Doped With Gold Nanoparticles
description	This study makes use of the advantage of normoxic polymer gels which are composed of two different monomer, 2-Hydroxyethyl Acrylate (HEA) and 2-Hydroxyethyl Methacrylate (HEMA) and N,N’-Methylene-bisacrylamide (BIS) as the crosslinker. To enable the fabrication of polymer gel to be done under the normal atmospheric condition, Ascorbic Acid is added as the anti-oxidant. As past studies had mainly been done using high energy sources, this study also focuses on using high energy x-ray source as in linear accelerator (LINAC) as well as a diagnostic x-ray unit as the main energy source. Dose sensitivity is property investigated in studying the behavior of dose distribution in the polymer gel. Magnetic Resonance Imaging (MRI) is the main polymerization imaging readout instrument before the images are used for further calculation of dose sensitivity. The results obtained are backed up by the analysis using UV-Visible spectrophotometer. In general, the dose sensitivity is directly proportional to the irradiation energy, monomer concentration and AuNPs size. When HEMA is used as the monomer, higher irradiation dose by LINAC increases the absorption of light. This is true for all the size of AuNPs used in this study (15nm, 20 nm, 40nm, 50nm and 80nm). Except for 50nm AuNP size, samples irradiated with dose of 30Gy shows a decreasing absorption of light at wavelength over 500nm. The decreasing pattern goes below than the samples irradiated with 10Gy and 20Gy. The result shows that at low x-ray energy, the size of AuNP has an impact on the polymerization. Higher concentration of monomer does not affect the polymerization significantly at the low energy level. At high x-ray energy
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Hisham, Muhd Hazwan Hakim
author_facet	Hisham, Muhd Hazwan Hakim
author_sort	Hisham, Muhd Hazwan Hakim
title	Development And Characterization Of Polymer Gel Dosimeter Doped With Gold Nanoparticles
title_short	Development And Characterization Of Polymer Gel Dosimeter Doped With Gold Nanoparticles
title_full	Development And Characterization Of Polymer Gel Dosimeter Doped With Gold Nanoparticles
title_fullStr	Development And Characterization Of Polymer Gel Dosimeter Doped With Gold Nanoparticles
title_full_unstemmed	Development And Characterization Of Polymer Gel Dosimeter Doped With Gold Nanoparticles
title_sort	development and characterization of polymer gel dosimeter doped with gold nanoparticles
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2023
url	http://eprints.usm.my/60648/1/MUHD%20HAZWAN%20HAKIM%20BIN%20HISHAM%20-%20TESIS24.pdf
_version_	1804888979433062400

Development And Characterization Of Polymer Gel Dosimeter Doped With Gold Nanoparticles

Similar Items