Synthesis And Evaluation Of Poly (Ethylene) Oxide/erbium Oxide As Potential Diagnostic Nanofibres For Magnetic Resonance Imaging

Synthesis And Evaluation Of Poly (Ethylene) Oxide/erbium Oxide As Potential Diagnostic Nanofibres For Magnetic Resonance Imaging

Advances in nanotechnology have led to the development of nanoscale materials for diagnostic applications, with a high potential to improve cancer diagnosis value, significantly impacting the future of healthcare. A diagnostic agent for magnetic resonance imaging (MRI) was developed in the current s...

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Main Author: Jamil, Munirah
Format: Thesis
Language:English
Published: 2023
Subjects:
QC1 Physics (General)
Online Access:http://eprints.usm.my/60649/1/MUNIRAH%20BINTI%20JAMIL%20-%20TESIS24.pdf
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spelling my-usm-ep.606492024-05-17T09:05:49Z Synthesis And Evaluation Of Poly (Ethylene) Oxide/erbium Oxide As Potential Diagnostic Nanofibres For Magnetic Resonance Imaging 2023-09 Jamil, Munirah QC1 Physics (General) Advances in nanotechnology have led to the development of nanoscale materials for diagnostic applications, with a high potential to improve cancer diagnosis value, significantly impacting the future of healthcare. A diagnostic agent for magnetic resonance imaging (MRI) was developed in the current study using the electrospinning method to embed erbium oxide (Er2O3) nanoparticles in a poly (ethylene) oxide (PEO) matrix. Moreover, the characteristics of PEO and PEO/Er2O3 nanofibres were confirmed using FESEM-EDX, AFM, FTIR, UV-Vis, Zetasizer, HRTEM, XRD, and ICP-OES. In vitro cell cytotoxicity and colony formation studies were conducted on MCF-7 cells to investigate the effects of PEO and PEO/Er2O3 nanofibre formulations on cancer progression characteristics. Findings demonstrated that the polymer blend formulations with and without nanofiller affected fibre diameter, thickness, and surface roughness. Findings also revealed that PEO nanofibres exhibited non-cytotoxic characteristics towards MCF-7 cells. The 5 wt% PEO nanofibre (P5) was recommended as the optimal nanofibre formulation suitable as a polymer matrix or carrier for diagnostic purposes. Further cytotoxicity investigation of PEO/Er2O3 nanofibres demonstrated cell proliferation over nanofiller loading for low dose concentration from 0 – 100 μg/ml, whereas a reduction in cell viability was observed for high dose concentration from 100 – 1000 μg/ml. Nevertheless, none of the formulations inhibited 50% of the cell viability. 2023-09 Thesis http://eprints.usm.my/60649/ http://eprints.usm.my/60649/1/MUNIRAH%20BINTI%20JAMIL%20-%20TESIS24.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Fizik
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic QC1 Physics (General)
spellingShingle QC1 Physics (General)
Jamil, Munirah
Synthesis And Evaluation Of Poly (Ethylene) Oxide/erbium Oxide As Potential Diagnostic Nanofibres For Magnetic Resonance Imaging
description Advances in nanotechnology have led to the development of nanoscale materials for diagnostic applications, with a high potential to improve cancer diagnosis value, significantly impacting the future of healthcare. A diagnostic agent for magnetic resonance imaging (MRI) was developed in the current study using the electrospinning method to embed erbium oxide (Er2O3) nanoparticles in a poly (ethylene) oxide (PEO) matrix. Moreover, the characteristics of PEO and PEO/Er2O3 nanofibres were confirmed using FESEM-EDX, AFM, FTIR, UV-Vis, Zetasizer, HRTEM, XRD, and ICP-OES. In vitro cell cytotoxicity and colony formation studies were conducted on MCF-7 cells to investigate the effects of PEO and PEO/Er2O3 nanofibre formulations on cancer progression characteristics. Findings demonstrated that the polymer blend formulations with and without nanofiller affected fibre diameter, thickness, and surface roughness. Findings also revealed that PEO nanofibres exhibited non-cytotoxic characteristics towards MCF-7 cells. The 5 wt% PEO nanofibre (P5) was recommended as the optimal nanofibre formulation suitable as a polymer matrix or carrier for diagnostic purposes. Further cytotoxicity investigation of PEO/Er2O3 nanofibres demonstrated cell proliferation over nanofiller loading for low dose concentration from 0 – 100 μg/ml, whereas a reduction in cell viability was observed for high dose concentration from 100 – 1000 μg/ml. Nevertheless, none of the formulations inhibited 50% of the cell viability.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Jamil, Munirah
author_facet Jamil, Munirah
author_sort Jamil, Munirah
title Synthesis And Evaluation Of Poly (Ethylene) Oxide/erbium Oxide As Potential Diagnostic Nanofibres For Magnetic Resonance Imaging
title_short Synthesis And Evaluation Of Poly (Ethylene) Oxide/erbium Oxide As Potential Diagnostic Nanofibres For Magnetic Resonance Imaging
title_full Synthesis And Evaluation Of Poly (Ethylene) Oxide/erbium Oxide As Potential Diagnostic Nanofibres For Magnetic Resonance Imaging
title_fullStr Synthesis And Evaluation Of Poly (Ethylene) Oxide/erbium Oxide As Potential Diagnostic Nanofibres For Magnetic Resonance Imaging
title_full_unstemmed Synthesis And Evaluation Of Poly (Ethylene) Oxide/erbium Oxide As Potential Diagnostic Nanofibres For Magnetic Resonance Imaging
title_sort synthesis and evaluation of poly (ethylene) oxide/erbium oxide as potential diagnostic nanofibres for magnetic resonance imaging
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Fizik
publishDate 2023
url http://eprints.usm.my/60649/1/MUNIRAH%20BINTI%20JAMIL%20-%20TESIS24.pdf
_version_ 1804888979684720640

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