Evaluation of the retinal vascular calibres and its associated factors in children with type 1 diabetes mellitus

Background: Poor glycaemic control in patients with type 1 diabetes mellitus (Type 1 DM) is closely associated with an increased risk of microvascular complications. Our study aims to determine the mean retinal arteriolar and venular calibres between the good and poor glycaemic control at baselin...

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Main Author:	Bari, Muhd Syafi Abd
Format:	Thesis
Language:	English
Published:	2021
Subjects:	R Medicine RE Ophthalmology
Online Access:	http://eprints.usm.my/60704/1/Muhd%20Syafi%20Abd%20Bari-E.pdf
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spelling	my-usm-ep.607042024-07-18T03:02:51Z Evaluation of the retinal vascular calibres and its associated factors in children with type 1 diabetes mellitus 2021 Bari, Muhd Syafi Abd R Medicine RA440-440.87 Study and teaching. Research RE Ophthalmology Background: Poor glycaemic control in patients with type 1 diabetes mellitus (Type 1 DM) is closely associated with an increased risk of microvascular complications. Our study aims to determine the mean retinal arteriolar and venular calibres between the good and poor glycaemic control at baseline visit, mid visit and last visit. We also look into the co-factors associated with the retinal vascular calibres in children with type 1 DM. Methods: A cross-sectional prospective hospital-based study involving children with Type 1 DM. The participants were recruited from Ophthalmology and Paediatric Clinics of Universiti Sains Malaysia Hospital. Fundus photo of right eye were taken at baseline, mid and final visit and analysed by Singapore 1 Vessels Analysis (SIVA). HbA1c at each visit were documented. Main Outcome Measure: Mean central arteriolar equivalent (CRAE) and venular equivalent (CRVE) in good and poor glycaemic control were determined at each visit and its associated factors were analysed. Results: The mean presenting age were 12.5 (2.24) years old. Majority of the participants were Malay race and mostly had poor glycaemic control. The mean CRAE and CRVE were not significantly differ for both group at each visit. However, the mean CRVE were significantly wider (p=0.037) in poor glycaemic control along the duration of follow up. Age, duration of DM, blood pressure, BMI and HbA1c are not associated with vascular calibres. Conclusion: A wider CRVE is associated with poorly glycaemic control DM. It can be one of earlier indicator in detecting the progression to diabetic retinopathy. In this closer and shorter duration of follow up study, no significant associated factors between age, duration, blood pressure, BMI and glycaemic control with retinal vascular calibres. 2021 Thesis http://eprints.usm.my/60704/ http://eprints.usm.my/60704/1/Muhd%20Syafi%20Abd%20Bari-E.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine R Medicine RE Ophthalmology
spellingShingle	R Medicine R Medicine RE Ophthalmology Bari, Muhd Syafi Abd Evaluation of the retinal vascular calibres and its associated factors in children with type 1 diabetes mellitus
description	Background: Poor glycaemic control in patients with type 1 diabetes mellitus (Type 1 DM) is closely associated with an increased risk of microvascular complications. Our study aims to determine the mean retinal arteriolar and venular calibres between the good and poor glycaemic control at baseline visit, mid visit and last visit. We also look into the co-factors associated with the retinal vascular calibres in children with type 1 DM. Methods: A cross-sectional prospective hospital-based study involving children with Type 1 DM. The participants were recruited from Ophthalmology and Paediatric Clinics of Universiti Sains Malaysia Hospital. Fundus photo of right eye were taken at baseline, mid and final visit and analysed by Singapore 1 Vessels Analysis (SIVA). HbA1c at each visit were documented. Main Outcome Measure: Mean central arteriolar equivalent (CRAE) and venular equivalent (CRVE) in good and poor glycaemic control were determined at each visit and its associated factors were analysed. Results: The mean presenting age were 12.5 (2.24) years old. Majority of the participants were Malay race and mostly had poor glycaemic control. The mean CRAE and CRVE were not significantly differ for both group at each visit. However, the mean CRVE were significantly wider (p=0.037) in poor glycaemic control along the duration of follow up. Age, duration of DM, blood pressure, BMI and HbA1c are not associated with vascular calibres. Conclusion: A wider CRVE is associated with poorly glycaemic control DM. It can be one of earlier indicator in detecting the progression to diabetic retinopathy. In this closer and shorter duration of follow up study, no significant associated factors between age, duration, blood pressure, BMI and glycaemic control with retinal vascular calibres.
format	Thesis
qualification_level	Master's degree
author	Bari, Muhd Syafi Abd
author_facet	Bari, Muhd Syafi Abd
author_sort	Bari, Muhd Syafi Abd
title	Evaluation of the retinal vascular calibres and its associated factors in children with type 1 diabetes mellitus
title_short	Evaluation of the retinal vascular calibres and its associated factors in children with type 1 diabetes mellitus
title_full	Evaluation of the retinal vascular calibres and its associated factors in children with type 1 diabetes mellitus
title_fullStr	Evaluation of the retinal vascular calibres and its associated factors in children with type 1 diabetes mellitus
title_full_unstemmed	Evaluation of the retinal vascular calibres and its associated factors in children with type 1 diabetes mellitus
title_sort	evaluation of the retinal vascular calibres and its associated factors in children with type 1 diabetes mellitus
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2021
url	http://eprints.usm.my/60704/1/Muhd%20Syafi%20Abd%20Bari-E.pdf
_version_	1804888988445573120

Evaluation of the retinal vascular calibres and its associated factors in children with type 1 diabetes mellitus

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