Diagnosis Of Dengue Infection Using Metabolome Analysis (Biomarkers Profiling)

Dengue is a major health and pressing threat to Malaysia with increasing atypical manifestations. These including encephalopathy, hepatic failure, renal failure, myocarditis and rhabdomyolysis which.have been attributed chiefly to metabolic alterations. Therefore, the metabolomics approach was us...

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Main Author:	Noor, Nurul Shahfiza
Format:	Thesis
Language:	English
Published:	2014
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/60798/1/24%20Pages%20from%2000001779829.pdf
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spelling	my-usm-ep.607982024-07-05T07:23:23Z Diagnosis Of Dengue Infection Using Metabolome Analysis (Biomarkers Profiling) 2014-04 Noor, Nurul Shahfiza RS1-441 Pharmacy and materia medica Dengue is a major health and pressing threat to Malaysia with increasing atypical manifestations. These including encephalopathy, hepatic failure, renal failure, myocarditis and rhabdomyolysis which.have been attributed chiefly to metabolic alterations. Therefore, the metabolomics approach was used to investigate for metabolite candidates that potentially could be utilized as an indicator for dengue disease; leads to dengue severity. In this study, attempt was made to determine the metabolic response associate with dengue infection by means of 11-1 NMR-based metabolomic spectrometry. We also explored the differences in gender infected with dengue disease. Fifty-two patients diagnosed with dengue fever at Penang General Hospital and fourty-three healthy individuals were recruited in this study. The mid-stream urine collected was analyzed with 11-1 NMR spectroscopy, followed by chemometric multivariate analysis. Two types of pattern recognitions were employed, namely, Principle Component Analysis (PCA) and Orthogonal Partial Least SquareDiscriminant Analysis (OPLS-DA). NMR signals which highlighted in the OPLS-DA S-plot were further selected and identified using Human Metabolome Database (HMDB), Chenornx Profiler and from published literature. 2014-04 Thesis http://eprints.usm.my/60798/ http://eprints.usm.my/60798/1/24%20Pages%20from%2000001779829.pdf application/pdf en public masters Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Noor, Nurul Shahfiza Diagnosis Of Dengue Infection Using Metabolome Analysis (Biomarkers Profiling)
description	Dengue is a major health and pressing threat to Malaysia with increasing atypical manifestations. These including encephalopathy, hepatic failure, renal failure, myocarditis and rhabdomyolysis which.have been attributed chiefly to metabolic alterations. Therefore, the metabolomics approach was used to investigate for metabolite candidates that potentially could be utilized as an indicator for dengue disease; leads to dengue severity. In this study, attempt was made to determine the metabolic response associate with dengue infection by means of 11-1 NMR-based metabolomic spectrometry. We also explored the differences in gender infected with dengue disease. Fifty-two patients diagnosed with dengue fever at Penang General Hospital and fourty-three healthy individuals were recruited in this study. The mid-stream urine collected was analyzed with 11-1 NMR spectroscopy, followed by chemometric multivariate analysis. Two types of pattern recognitions were employed, namely, Principle Component Analysis (PCA) and Orthogonal Partial Least SquareDiscriminant Analysis (OPLS-DA). NMR signals which highlighted in the OPLS-DA S-plot were further selected and identified using Human Metabolome Database (HMDB), Chenornx Profiler and from published literature.
format	Thesis
qualification_level	Master's degree
author	Noor, Nurul Shahfiza
author_facet	Noor, Nurul Shahfiza
author_sort	Noor, Nurul Shahfiza
title	Diagnosis Of Dengue Infection Using Metabolome Analysis (Biomarkers Profiling)
title_short	Diagnosis Of Dengue Infection Using Metabolome Analysis (Biomarkers Profiling)
title_full	Diagnosis Of Dengue Infection Using Metabolome Analysis (Biomarkers Profiling)
title_fullStr	Diagnosis Of Dengue Infection Using Metabolome Analysis (Biomarkers Profiling)
title_full_unstemmed	Diagnosis Of Dengue Infection Using Metabolome Analysis (Biomarkers Profiling)
title_sort	diagnosis of dengue infection using metabolome analysis (biomarkers profiling)
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2014
url	http://eprints.usm.my/60798/1/24%20Pages%20from%2000001779829.pdf
_version_	1804888998684917760

Diagnosis Of Dengue Infection Using Metabolome Analysis (Biomarkers Profiling)

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