Fabrication And Characterisation Of Methylene Blue- Loaded Graphene Oxide And Reduced Graphene Oxide For Photodynamic Therapy Application

Breast cancer is a common type of cancer diagnosed in women. The choice of treatment is important to reduce the morbidity and mortality rate. Photodynamic therapy (PDT) is one of the techniques introduced to treat diseases such as cancers by employing light-activated molecules known as photosensitis...

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Main Author: Ung, Yee Tze
Format: Thesis
Language:English
Published: 2023
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Online Access:http://eprints.usm.my/60824/1/UNG%20YEE%20TZE%20-%20TESIS24.pdf
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spelling my-usm-ep.608242024-07-12T08:45:26Z Fabrication And Characterisation Of Methylene Blue- Loaded Graphene Oxide And Reduced Graphene Oxide For Photodynamic Therapy Application 2023-07 Ung, Yee Tze RS1-441 Pharmacy and materia medica Breast cancer is a common type of cancer diagnosed in women. The choice of treatment is important to reduce the morbidity and mortality rate. Photodynamic therapy (PDT) is one of the techniques introduced to treat diseases such as cancers by employing light-activated molecules known as photosensitisers to produce reactive oxygen species and subsequently inducing cancer cells apoptosis. As PDT is a non-invasive and targeted treatment, it provides advantages including lowering the potential side effects while improving the treatment efficiency. Graphene-based materials are getting more attention in pharmaceutical applications due to its attractive physicochemical properties including large surface area and easy modification for drug loading and targeting purposes. As the photosensitiser alone was unable to specifically target the breast cancer without causing cytotoxicity towards the normal cells, a suitable drug carrier to be able to control the release of the drug towards the breast cancer should be investigated. This study explores the effectiveness between graphene oxide (GO) and reduced graphene oxide (rGO) in the loading of methylene blue (MB) as well as the in vitro cytotoxic effect of GO-MB and rGO-MB on breast cancer cells. In this study, GO and rGO were synthesised through improved Hummers’ method and chemical reduction method respectively. The 2023-07 Thesis http://eprints.usm.my/60824/ http://eprints.usm.my/60824/1/UNG%20YEE%20TZE%20-%20TESIS24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Ung, Yee Tze
Fabrication And Characterisation Of Methylene Blue- Loaded Graphene Oxide And Reduced Graphene Oxide For Photodynamic Therapy Application
description Breast cancer is a common type of cancer diagnosed in women. The choice of treatment is important to reduce the morbidity and mortality rate. Photodynamic therapy (PDT) is one of the techniques introduced to treat diseases such as cancers by employing light-activated molecules known as photosensitisers to produce reactive oxygen species and subsequently inducing cancer cells apoptosis. As PDT is a non-invasive and targeted treatment, it provides advantages including lowering the potential side effects while improving the treatment efficiency. Graphene-based materials are getting more attention in pharmaceutical applications due to its attractive physicochemical properties including large surface area and easy modification for drug loading and targeting purposes. As the photosensitiser alone was unable to specifically target the breast cancer without causing cytotoxicity towards the normal cells, a suitable drug carrier to be able to control the release of the drug towards the breast cancer should be investigated. This study explores the effectiveness between graphene oxide (GO) and reduced graphene oxide (rGO) in the loading of methylene blue (MB) as well as the in vitro cytotoxic effect of GO-MB and rGO-MB on breast cancer cells. In this study, GO and rGO were synthesised through improved Hummers’ method and chemical reduction method respectively. The
format Thesis
qualification_level Master's degree
author Ung, Yee Tze
author_facet Ung, Yee Tze
author_sort Ung, Yee Tze
title Fabrication And Characterisation Of Methylene Blue- Loaded Graphene Oxide And Reduced Graphene Oxide For Photodynamic Therapy Application
title_short Fabrication And Characterisation Of Methylene Blue- Loaded Graphene Oxide And Reduced Graphene Oxide For Photodynamic Therapy Application
title_full Fabrication And Characterisation Of Methylene Blue- Loaded Graphene Oxide And Reduced Graphene Oxide For Photodynamic Therapy Application
title_fullStr Fabrication And Characterisation Of Methylene Blue- Loaded Graphene Oxide And Reduced Graphene Oxide For Photodynamic Therapy Application
title_full_unstemmed Fabrication And Characterisation Of Methylene Blue- Loaded Graphene Oxide And Reduced Graphene Oxide For Photodynamic Therapy Application
title_sort fabrication and characterisation of methylene blue- loaded graphene oxide and reduced graphene oxide for photodynamic therapy application
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Farmasi
publishDate 2023
url http://eprints.usm.my/60824/1/UNG%20YEE%20TZE%20-%20TESIS24.pdf
_version_ 1804889004768755712