Cytotoxic Activity Of Isolated Alkaloids From The Bark Of Kopsia Terengganensis (Apocynaceae) And Corrosion Inhibition Studies Of Its Extract

The use of natural products in developing chemotherapy agents has shown a positive impact in the oncology field. Besides, they also showed a significant result as a corrosion inhibitor. Hence, this study aims to evaluate the cytotoxic activity and corrosion inhibition potential of the crude extract...

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Main Author:	Hanafi, Wan Nur Huda Wan
Format:	Thesis
Language:	English
Published:	2023
Subjects:	QD1-999 Chemistry
Online Access:	http://eprints.usm.my/60867/1/WAN%20NUR%20HUDA%20BINTI%20WAN%20HANAFI%20-%20TESIS24.pdf
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id	my-usm-ep.60867
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spelling	my-usm-ep.608672024-07-26T08:18:44Z Cytotoxic Activity Of Isolated Alkaloids From The Bark Of Kopsia Terengganensis (Apocynaceae) And Corrosion Inhibition Studies Of Its Extract 2023-09 Hanafi, Wan Nur Huda Wan QD1-999 Chemistry The use of natural products in developing chemotherapy agents has shown a positive impact in the oncology field. Besides, they also showed a significant result as a corrosion inhibitor. Hence, this study aims to evaluate the cytotoxic activity and corrosion inhibition potential of the crude extract and isolated alkaloids from Kopsia terengganensis (K. terengganensis). The experimental involved extraction and isolation of alkaloids using different chromatographic methods, structural elucidation using various chromatographic techniques and evaluation of cytotoxic activity on HT-29 colorectal adenocarcinoma. Meanwhile, corrosion inhibition studies included weight loss studies, electrochemical studies, and surface analysis. The extraction and isolation process resulted in seven alkaloid compounds: eburnamine (90), isoeburnamine (58), eburnaminol (99), larutensine (100), eburnamenine (114), eburnamonine (56) and quebrachamine (148). In the cytotoxic activity, only compound 99 was able to suppress the growth of HT-29 with moderate activity (IC50 =75.8± 3.06 μM). For the corrosion inhibition potential, the alkaloid crude showed significant results (80-90% inhibition efficiency) in both weight loss and electrochemical studies. The inhibitor followed the Langmuir adsorption isotherm and the formation of an inhibitive film on the mild steel surface was proved in the surface analysis. In conclusion, the alkaloids from K. terengganensis were noteworthy to be investigated in both cancer and corrosion inhibition studies as it gives a positive result in the toxicity towards cancer cells and also mitigated the mild steel corrosion. 2023-09 Thesis http://eprints.usm.my/60867/ http://eprints.usm.my/60867/1/WAN%20NUR%20HUDA%20BINTI%20WAN%20HANAFI%20-%20TESIS24.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Kimia
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QD1-999 Chemistry
spellingShingle	QD1-999 Chemistry Hanafi, Wan Nur Huda Wan Cytotoxic Activity Of Isolated Alkaloids From The Bark Of Kopsia Terengganensis (Apocynaceae) And Corrosion Inhibition Studies Of Its Extract
description	The use of natural products in developing chemotherapy agents has shown a positive impact in the oncology field. Besides, they also showed a significant result as a corrosion inhibitor. Hence, this study aims to evaluate the cytotoxic activity and corrosion inhibition potential of the crude extract and isolated alkaloids from Kopsia terengganensis (K. terengganensis). The experimental involved extraction and isolation of alkaloids using different chromatographic methods, structural elucidation using various chromatographic techniques and evaluation of cytotoxic activity on HT-29 colorectal adenocarcinoma. Meanwhile, corrosion inhibition studies included weight loss studies, electrochemical studies, and surface analysis. The extraction and isolation process resulted in seven alkaloid compounds: eburnamine (90), isoeburnamine (58), eburnaminol (99), larutensine (100), eburnamenine (114), eburnamonine (56) and quebrachamine (148). In the cytotoxic activity, only compound 99 was able to suppress the growth of HT-29 with moderate activity (IC50 =75.8± 3.06 μM). For the corrosion inhibition potential, the alkaloid crude showed significant results (80-90% inhibition efficiency) in both weight loss and electrochemical studies. The inhibitor followed the Langmuir adsorption isotherm and the formation of an inhibitive film on the mild steel surface was proved in the surface analysis. In conclusion, the alkaloids from K. terengganensis were noteworthy to be investigated in both cancer and corrosion inhibition studies as it gives a positive result in the toxicity towards cancer cells and also mitigated the mild steel corrosion.
format	Thesis
qualification_level	Master's degree
author	Hanafi, Wan Nur Huda Wan
author_facet	Hanafi, Wan Nur Huda Wan
author_sort	Hanafi, Wan Nur Huda Wan
title	Cytotoxic Activity Of Isolated Alkaloids From The Bark Of Kopsia Terengganensis (Apocynaceae) And Corrosion Inhibition Studies Of Its Extract
title_short	Cytotoxic Activity Of Isolated Alkaloids From The Bark Of Kopsia Terengganensis (Apocynaceae) And Corrosion Inhibition Studies Of Its Extract
title_full	Cytotoxic Activity Of Isolated Alkaloids From The Bark Of Kopsia Terengganensis (Apocynaceae) And Corrosion Inhibition Studies Of Its Extract
title_fullStr	Cytotoxic Activity Of Isolated Alkaloids From The Bark Of Kopsia Terengganensis (Apocynaceae) And Corrosion Inhibition Studies Of Its Extract
title_full_unstemmed	Cytotoxic Activity Of Isolated Alkaloids From The Bark Of Kopsia Terengganensis (Apocynaceae) And Corrosion Inhibition Studies Of Its Extract
title_sort	cytotoxic activity of isolated alkaloids from the bark of kopsia terengganensis (apocynaceae) and corrosion inhibition studies of its extract
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kimia
publishDate	2023
url	http://eprints.usm.my/60867/1/WAN%20NUR%20HUDA%20BINTI%20WAN%20HANAFI%20-%20TESIS24.pdf
_version_	1811772852092796928

Cytotoxic Activity Of Isolated Alkaloids From The Bark Of Kopsia Terengganensis (Apocynaceae) And Corrosion Inhibition Studies Of Its Extract

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