The relationship between mast cell density and microvessel density with grading of breast carcinoma.
The relationship between mast cell density and microvessel density with grading of breast carcinoma : There is increasing evidence that indicates the essential role of tumour microenvironment in relation to tumour initiation and progression. The need to further explore this role is crucial as it can...
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| Format: | Thesis |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | http://eprints.usm.my/60979/1/DR%20DARLINA%20BINTI%20ISMAIL%20-%20e.pdf |
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| Summary: | The relationship between mast cell density and microvessel density with grading of breast carcinoma : There is increasing evidence that indicates the essential role of tumour microenvironment in relation to tumour initiation and progression. The need to further explore this role is crucial as it can provide important prognostic and predictive information on tumour as well as offering potential targets for therapeutic attack. In this study, we aimed to analyze the relationship between mast cell density and microvessel density with grading of breast carcinoma and the correlation between
these two variables. In addition, we also analyzed the relationship between MCD and MVD with other clinicopathological parameters. 95 cases of breast carcinoma, diagnosed within 2009 to 2011 in Hospital Raja Permaisuri Bainun, Ipoh, were reviewed. We observed significant association between mast cell density with breast carcinoma grade (p=0.04), with higher count
seen in low grade tumour. However, there was no significant association seen with microvessel density with grading of breast carcinoma (p=0.25). Both mast cell density and microvessel density did not show any statistically significant association. Among the clinicopathological parameters, it was observed that high mast cell density was seen in cases negative for lymph node invasion (p=0.01), whereas high microvessel
density was noted in cases positive for vascular invasion (p=0.03). Other clinicopathological parameters did not show statistically significant association. As a conclusion, higher mast cell density was seen in low grade tumour and in cases
without lymph nodes metastasis, as observed in other studies. However, the finding for microvessel density did not concur with other similar studies. |
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