Dietary pattern and risk factors associated with newly diagnosed colorectal cancer and predictive factors for quality of life among survivors

Colorectal cancer (CRC) is the second most common diagnosed cancer in Malaysia while the third in worldwide and Asia. This study had 3 phases: food frequency questionnaire (FFQ) validation, baseline and follow-up. The FFQ was developed specifically related to CRC risk consisted of 142 food items. At...

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Main Author:	Rashid, Ainaa Almardhiyah Abd
Format:	Thesis
Language:	English
Published:	2024
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/61001/1/AINAA%20ALMARDHIYAH%20BINTI%20ABD%20RASHID-FINAL%20THESIS%20P-SKD000919%28R%29-E.pdf
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spelling	my-usm-ep.610012024-08-21T03:26:59Z Dietary pattern and risk factors associated with newly diagnosed colorectal cancer and predictive factors for quality of life among survivors 2024-05 Rashid, Ainaa Almardhiyah Abd R Medicine RA440-440.87 Study and teaching. Research RC254-282 Neoplasms. Tumors. Oncology (including Cancer) RC799-869 Diseases of the digestive system. Gastroenterology Colorectal cancer (CRC) is the second most common diagnosed cancer in Malaysia while the third in worldwide and Asia. This study had 3 phases: food frequency questionnaire (FFQ) validation, baseline and follow-up. The FFQ was developed specifically related to CRC risk consisted of 142 food items. At baseline phase, 341 patients (107 cases and 234 controls) enrolled to complete anthropometric assessments and questionnaire to predict risk factors and dietary pattern associated with CRC. Follow up assessment on anthropometric measurements and quality of life (QOL) using EORTC QLQ C30 and CR29 were performed after 6 months post diagnosis. As a result, this FFQ had good reproducibility and validity. Aged >51 years old (Odds ratio (OR) 7.72; 95% CI = 1.10–54.4), blood presence in stool (OR 6.30; 95% CI = 1.89–20.99), unintended weight loss (OR 21.95; 95% CI = 6.04–79.76) and reduced fat mass (OR 0.92; 95% CI = 0.85–1.00) had higher risk of getting CRC. Meanwhile the Processed diet pattern (OR = 3.45; 95% CI = 1.25–9.52) was found to be associated with CRC risk. The follow up study showed older patients and chronic stage predicts low QOL. In conclusion, the newly developed FFQ was good to assess dietary intake related to CRC in Malaysia. Predictor of CRC consisted of aged >51 years old, blood presence in stool, unintended weight loss, reduced fat mass and adherence to the Processed diet pattern. Predictive of low GHS/QOL was related to older patients and those with chronic stage of CRC. The risk factors of CRC, dietary pattern related to CRC and predictive factors of low QOL found in this study should be given more emphasis by policy makers and healthcare practitioners for the prevention and management of CRC patients in the future. 2024-05 Thesis http://eprints.usm.my/61001/ http://eprints.usm.my/61001/1/AINAA%20ALMARDHIYAH%20BINTI%20ABD%20RASHID-FINAL%20THESIS%20P-SKD000919%28R%29-E.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kesihatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine R Medicine R Medicine R Medicine
spellingShingle	R Medicine R Medicine R Medicine R Medicine Rashid, Ainaa Almardhiyah Abd Dietary pattern and risk factors associated with newly diagnosed colorectal cancer and predictive factors for quality of life among survivors
description	Colorectal cancer (CRC) is the second most common diagnosed cancer in Malaysia while the third in worldwide and Asia. This study had 3 phases: food frequency questionnaire (FFQ) validation, baseline and follow-up. The FFQ was developed specifically related to CRC risk consisted of 142 food items. At baseline phase, 341 patients (107 cases and 234 controls) enrolled to complete anthropometric assessments and questionnaire to predict risk factors and dietary pattern associated with CRC. Follow up assessment on anthropometric measurements and quality of life (QOL) using EORTC QLQ C30 and CR29 were performed after 6 months post diagnosis. As a result, this FFQ had good reproducibility and validity. Aged >51 years old (Odds ratio (OR) 7.72; 95% CI = 1.10–54.4), blood presence in stool (OR 6.30; 95% CI = 1.89–20.99), unintended weight loss (OR 21.95; 95% CI = 6.04–79.76) and reduced fat mass (OR 0.92; 95% CI = 0.85–1.00) had higher risk of getting CRC. Meanwhile the Processed diet pattern (OR = 3.45; 95% CI = 1.25–9.52) was found to be associated with CRC risk. The follow up study showed older patients and chronic stage predicts low QOL. In conclusion, the newly developed FFQ was good to assess dietary intake related to CRC in Malaysia. Predictor of CRC consisted of aged >51 years old, blood presence in stool, unintended weight loss, reduced fat mass and adherence to the Processed diet pattern. Predictive of low GHS/QOL was related to older patients and those with chronic stage of CRC. The risk factors of CRC, dietary pattern related to CRC and predictive factors of low QOL found in this study should be given more emphasis by policy makers and healthcare practitioners for the prevention and management of CRC patients in the future.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Rashid, Ainaa Almardhiyah Abd
author_facet	Rashid, Ainaa Almardhiyah Abd
author_sort	Rashid, Ainaa Almardhiyah Abd
title	Dietary pattern and risk factors associated with newly diagnosed colorectal cancer and predictive factors for quality of life among survivors
title_short	Dietary pattern and risk factors associated with newly diagnosed colorectal cancer and predictive factors for quality of life among survivors
title_full	Dietary pattern and risk factors associated with newly diagnosed colorectal cancer and predictive factors for quality of life among survivors
title_fullStr	Dietary pattern and risk factors associated with newly diagnosed colorectal cancer and predictive factors for quality of life among survivors
title_full_unstemmed	Dietary pattern and risk factors associated with newly diagnosed colorectal cancer and predictive factors for quality of life among survivors
title_sort	dietary pattern and risk factors associated with newly diagnosed colorectal cancer and predictive factors for quality of life among survivors
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kesihatan
publishDate	2024
url	http://eprints.usm.my/61001/1/AINAA%20ALMARDHIYAH%20BINTI%20ABD%20RASHID-FINAL%20THESIS%20P-SKD000919%28R%29-E.pdf
_version_	1811772871193657344

Dietary pattern and risk factors associated with newly diagnosed colorectal cancer and predictive factors for quality of life among survivors

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