Mechanical properties and cytotoxicity studies of calcia stabilized zirconia (Ca-SZ) for dental application

Several studies can be found on zirconia as dental application but only few of them use calcium oxide (CaO) as its stabilizer. Mechanical aspects and cell studies were not covered, leaving a gap in the evidence regarding the mechanical properties and biocompatibility of Ca-SZ as dental materials. Ca...

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Main Author:	Johari, Anis Syamimi
Format:	Thesis
Language:	English
Published:	2024
Subjects:	R Medicine RK1-715 Dentistry
Online Access:	http://eprints.usm.my/61003/1/ANIS%20SYAMIMI%20BINTI%20JOHARI-FINAL%20THESIS%20P-SGM001219%28R%29-E.pdf
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spelling	my-usm-ep.610032024-08-21T03:22:10Z Mechanical properties and cytotoxicity studies of calcia stabilized zirconia (Ca-SZ) for dental application 2024-05 Johari, Anis Syamimi R Medicine RA440-440.87 Study and teaching. Research RK1-715 Dentistry Several studies can be found on zirconia as dental application but only few of them use calcium oxide (CaO) as its stabilizer. Mechanical aspects and cell studies were not covered, leaving a gap in the evidence regarding the mechanical properties and biocompatibility of Ca-SZ as dental materials. CaO synthesis from calcium nitrate tetrahydrate was used as metal precursor to produce Ca-SZ. Bioceramic Ca-SZ was sintered at three different sintering temperatures 1200°, 1300° and 1400°C. Ca-SZ was characterized using Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX) element analysis, X-ray Diffraction (XRD) for composition studies. Ca-SZ sample shows a good morphology under SEM observation. Increment of sintering temperature enhance the surface morphologies, the phase of Ca-SZ become intensified and transformed from monoclinic to tetragonal ZrO2 and the flexural strength increases. The mechanical properties for Ca-SZ at temperature 1400°C displayed a good result that was comparable with commercial CEREC Zirconia. Ca-SZ bioceramic sintered at 1400°C had comparable mechanical strength especially with regard to flexural that reach up to 535.3 MPa while CEREC Zirconia goes up to 683.18 MPa and fracture toughness 4.73 MPa m1/2 as that of CEREC Zirconia 4.91 MPa m1/2 The highest viability of Ca-SZ was at 24 hours incubation that reached 95% comparable with CEREC Zirconia at 97%. The LogIC50 of Ca-SZ at 24 hours incubation was 0.20417 mg/ml and comparable with CEREC Zirconia at 0.1995 mg/ml. The development of Ca-SZ can act as an alternative material for dental applications. 2024-05 Thesis http://eprints.usm.my/61003/ http://eprints.usm.my/61003/1/ANIS%20SYAMIMI%20BINTI%20JOHARI-FINAL%20THESIS%20P-SGM001219%28R%29-E.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Kesihatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine R Medicine RK1-715 Dentistry
spellingShingle	R Medicine R Medicine RK1-715 Dentistry Johari, Anis Syamimi Mechanical properties and cytotoxicity studies of calcia stabilized zirconia (Ca-SZ) for dental application
description	Several studies can be found on zirconia as dental application but only few of them use calcium oxide (CaO) as its stabilizer. Mechanical aspects and cell studies were not covered, leaving a gap in the evidence regarding the mechanical properties and biocompatibility of Ca-SZ as dental materials. CaO synthesis from calcium nitrate tetrahydrate was used as metal precursor to produce Ca-SZ. Bioceramic Ca-SZ was sintered at three different sintering temperatures 1200°, 1300° and 1400°C. Ca-SZ was characterized using Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX) element analysis, X-ray Diffraction (XRD) for composition studies. Ca-SZ sample shows a good morphology under SEM observation. Increment of sintering temperature enhance the surface morphologies, the phase of Ca-SZ become intensified and transformed from monoclinic to tetragonal ZrO2 and the flexural strength increases. The mechanical properties for Ca-SZ at temperature 1400°C displayed a good result that was comparable with commercial CEREC Zirconia. Ca-SZ bioceramic sintered at 1400°C had comparable mechanical strength especially with regard to flexural that reach up to 535.3 MPa while CEREC Zirconia goes up to 683.18 MPa and fracture toughness 4.73 MPa m1/2 as that of CEREC Zirconia 4.91 MPa m1/2 The highest viability of Ca-SZ was at 24 hours incubation that reached 95% comparable with CEREC Zirconia at 97%. The LogIC50 of Ca-SZ at 24 hours incubation was 0.20417 mg/ml and comparable with CEREC Zirconia at 0.1995 mg/ml. The development of Ca-SZ can act as an alternative material for dental applications.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Johari, Anis Syamimi
author_facet	Johari, Anis Syamimi
author_sort	Johari, Anis Syamimi
title	Mechanical properties and cytotoxicity studies of calcia stabilized zirconia (Ca-SZ) for dental application
title_short	Mechanical properties and cytotoxicity studies of calcia stabilized zirconia (Ca-SZ) for dental application
title_full	Mechanical properties and cytotoxicity studies of calcia stabilized zirconia (Ca-SZ) for dental application
title_fullStr	Mechanical properties and cytotoxicity studies of calcia stabilized zirconia (Ca-SZ) for dental application
title_full_unstemmed	Mechanical properties and cytotoxicity studies of calcia stabilized zirconia (Ca-SZ) for dental application
title_sort	mechanical properties and cytotoxicity studies of calcia stabilized zirconia (ca-sz) for dental application
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kesihatan
publishDate	2024
url	http://eprints.usm.my/61003/1/ANIS%20SYAMIMI%20BINTI%20JOHARI-FINAL%20THESIS%20P-SGM001219%28R%29-E.pdf
_version_	1811772871695925248

Mechanical properties and cytotoxicity studies of calcia stabilized zirconia (Ca-SZ) for dental application

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