Understanding Platelet Thrombogenicity Cascade Of The Biodegradable Chitosan Derivatives In Von Willebrand Disease In Vitro
Chitosan has become one of the most promising local hemostatic agents because it is of particular interest as it functions independently on platelets and normal clotting mechanisms. The present study was designed with the aim to test the ability of the mechanisms of blood platelets towards the ac...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2015
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/61120/1/8%20bit%20cmos%20hybrid%20cut.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
my-usm-ep.61120 |
|---|---|
| record_format |
uketd_dc |
| spelling |
my-usm-ep.611202024-09-13T08:30:00Z Understanding Platelet Thrombogenicity Cascade Of The Biodegradable Chitosan Derivatives In Von Willebrand Disease In Vitro 2015-11 Periayah, Mercy Halleluyah R735-854 Medical education. Medical schools. Research Chitosan has become one of the most promising local hemostatic agents because it is of particular interest as it functions independently on platelets and normal clotting mechanisms. The present study was designed with the aim to test the ability of the mechanisms of blood platelets towards the action of biodegradable chitosan in normal donors and von Willebrand disease (vWD) patients in vitro. This work determined the underlying mechanism of chitosan-induced platelet thrombogenicity and comprises experimental tests such as degradation ability; platelet: adhesion, activation: aggregation; coagulation analysis and hemostatic mediators: von Willebrand Factor (vWF), Factor 8 (FVIII), Thromboxane A2 (TXA2), P2Y12, glycoprotein IIbIIIa (GpIIbIIIa), Transforming Growth Factor- Beta 1 (TGF-β1) and Platelet Derived Growth Factor-AB (PDGF-AB). Comparative studies have been conducted to measure the hemostatic capacity of biodegradable 7% N,OCarboxymethylchitosan (NO-CMC) (with 0.45 mL collagen), 8% NO-CMC, Oligochitosan (O-C) and O-C 53. 2015-11 Thesis http://eprints.usm.my/61120/ http://eprints.usm.my/61120/1/8%20bit%20cmos%20hybrid%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Perubatan |
| institution |
Universiti Sains Malaysia |
| collection |
USM Institutional Repository |
| language |
English |
| topic |
R735-854 Medical education Medical schools Research |
| spellingShingle |
R735-854 Medical education Medical schools Research Periayah, Mercy Halleluyah Understanding Platelet Thrombogenicity Cascade Of The Biodegradable Chitosan Derivatives In Von Willebrand Disease In Vitro |
| description |
Chitosan has become one of the most promising local hemostatic agents because it is
of particular interest as it functions independently on platelets and normal clotting
mechanisms. The present study was designed with the aim to test the ability of the
mechanisms of blood platelets towards the action of biodegradable chitosan in
normal donors and von Willebrand disease (vWD) patients in vitro. This work
determined the underlying mechanism of chitosan-induced platelet thrombogenicity
and comprises experimental tests such as degradation ability; platelet: adhesion,
activation: aggregation; coagulation analysis and hemostatic mediators: von
Willebrand Factor (vWF), Factor 8 (FVIII), Thromboxane A2 (TXA2), P2Y12,
glycoprotein IIbIIIa (GpIIbIIIa), Transforming Growth Factor- Beta 1 (TGF-β1) and
Platelet Derived Growth Factor-AB (PDGF-AB). Comparative studies have been
conducted to measure the hemostatic capacity of biodegradable 7% N,OCarboxymethylchitosan
(NO-CMC) (with 0.45 mL collagen), 8% NO-CMC, Oligochitosan
(O-C) and O-C 53. |
| format |
Thesis |
| qualification_name |
Doctor of Philosophy (PhD.) |
| qualification_level |
Doctorate |
| author |
Periayah, Mercy Halleluyah |
| author_facet |
Periayah, Mercy Halleluyah |
| author_sort |
Periayah, Mercy Halleluyah |
| title |
Understanding Platelet Thrombogenicity Cascade
Of The Biodegradable Chitosan Derivatives
In Von Willebrand Disease In Vitro |
| title_short |
Understanding Platelet Thrombogenicity Cascade
Of The Biodegradable Chitosan Derivatives
In Von Willebrand Disease In Vitro |
| title_full |
Understanding Platelet Thrombogenicity Cascade
Of The Biodegradable Chitosan Derivatives
In Von Willebrand Disease In Vitro |
| title_fullStr |
Understanding Platelet Thrombogenicity Cascade
Of The Biodegradable Chitosan Derivatives
In Von Willebrand Disease In Vitro |
| title_full_unstemmed |
Understanding Platelet Thrombogenicity Cascade
Of The Biodegradable Chitosan Derivatives
In Von Willebrand Disease In Vitro |
| title_sort |
understanding platelet thrombogenicity cascade
of the biodegradable chitosan derivatives
in von willebrand disease in vitro |
| granting_institution |
Universiti Sains Malaysia |
| granting_department |
Pusat Pengajian Sains Perubatan |
| publishDate |
2015 |
| url |
http://eprints.usm.my/61120/1/8%20bit%20cmos%20hybrid%20cut.pdf |
| _version_ |
1811772881229578240 |