Characterization Of CTP Synthase In Zebrafish (Danio Rerio)

CTPS is an enzyme that catalyzes the synthesis of cytidine triphosphate (CTP), one of the four basic nucleotide triphosphates that make up DNA and RNA. CTPS dysregulation has been implicated in many different diseases and cancers. It was also shown previously that CTPS can form filamentous struct...

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Main Author:	Abdul Wahab, Nurul Wahidah
Format:	Thesis
Language:	English
Published:	2019
Subjects:	QP501-801 Animal biochemistry
Online Access:	http://eprints.usm.my/61170/1/Characterization%20of%20CTP%20synthase%20cut.pdf
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id	my-usm-ep.61170
record_format	uketd_dc
spelling	my-usm-ep.611702024-09-19T07:06:03Z Characterization Of CTP Synthase In Zebrafish (Danio Rerio) 2019-08 Abdul Wahab, Nurul Wahidah QP501-801 Animal biochemistry CTPS is an enzyme that catalyzes the synthesis of cytidine triphosphate (CTP), one of the four basic nucleotide triphosphates that make up DNA and RNA. CTPS dysregulation has been implicated in many different diseases and cancers. It was also shown previously that CTPS can form filamentous structures called cytoophidia. This structure was found on yeast, fruit flies and human. Nevertheless the mechanism behind cytoophidia formation is still vague. To date, there are no in depth studies yet on characterizing CTPS on Danio rerio (zebrafish) and as there are two CTPS genes in zebrafish i.e ctpsla and ctpslb utilizing zebrafish as model organism can further help to understand the CTPS and its cytoophidia. In this studies, the antibody staining results shows that in developing embryos, CTPS is concentrated on the pronephric duct area and the notochord at the end tail area. 2019-08 Thesis http://eprints.usm.my/61170/ http://eprints.usm.my/61170/1/Characterization%20of%20CTP%20synthase%20cut.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Kajihayat
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QP501-801 Animal biochemistry
spellingShingle	QP501-801 Animal biochemistry Abdul Wahab, Nurul Wahidah Characterization Of CTP Synthase In Zebrafish (Danio Rerio)
description	CTPS is an enzyme that catalyzes the synthesis of cytidine triphosphate (CTP), one of the four basic nucleotide triphosphates that make up DNA and RNA. CTPS dysregulation has been implicated in many different diseases and cancers. It was also shown previously that CTPS can form filamentous structures called cytoophidia. This structure was found on yeast, fruit flies and human. Nevertheless the mechanism behind cytoophidia formation is still vague. To date, there are no in depth studies yet on characterizing CTPS on Danio rerio (zebrafish) and as there are two CTPS genes in zebrafish i.e ctpsla and ctpslb utilizing zebrafish as model organism can further help to understand the CTPS and its cytoophidia. In this studies, the antibody staining results shows that in developing embryos, CTPS is concentrated on the pronephric duct area and the notochord at the end tail area.
format	Thesis
qualification_level	Master's degree
author	Abdul Wahab, Nurul Wahidah
author_facet	Abdul Wahab, Nurul Wahidah
author_sort	Abdul Wahab, Nurul Wahidah
title	Characterization Of CTP Synthase In Zebrafish (Danio Rerio)
title_short	Characterization Of CTP Synthase In Zebrafish (Danio Rerio)
title_full	Characterization Of CTP Synthase In Zebrafish (Danio Rerio)
title_fullStr	Characterization Of CTP Synthase In Zebrafish (Danio Rerio)
title_full_unstemmed	Characterization Of CTP Synthase In Zebrafish (Danio Rerio)
title_sort	characterization of ctp synthase in zebrafish (danio rerio)
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kajihayat
publishDate	2019
url	http://eprints.usm.my/61170/1/Characterization%20of%20CTP%20synthase%20cut.pdf
_version_	1811772888504598528

Characterization Of CTP Synthase In Zebrafish (Danio Rerio)

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