Development Of Denaturing High Performance Liquid Chromatography (Dhplc) In Detection Of Common Polymorphisms In The Multi-Drug Resistance (MDR1) Gene Among Malay Patients With Leukemia [QH324.9.L5 B138 2006 f rb].
Although the use of chemotherapy has evolved remarkably during the past 30 years for treatment in leukemia patients, it remains a difficult disease to treat where the main problem is drug resistance. This is due to over expression of multi-drug resistance gene (MDR1) and it’s over expression has bee...
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| Format: | Thesis |
| Language: | English |
| Published: |
2006
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| Online Access: | http://eprints.usm.my/8626/1/DEVELOPMENT_OF_DENATURING_HIGH_PERFORMANCE_LIQUID_CHROMATOGRAPHY_%28dHPLC%29_IN_DETECTION_OF_COMMON_POLYMORPHISMS_IN_THE_MULTI-DRUG_RESISTANCE_%28MDR1%29_GENE_IN_MALAY_PATIENTS_WITH_LEUKEMIA.pdf |
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| Summary: | Although the use of chemotherapy has evolved remarkably during the past 30 years for treatment in leukemia patients, it remains a difficult disease to treat where the main problem is drug resistance. This is due to over expression of multi-drug resistance gene (MDR1) and it’s over expression has been described in many tumors resistant to cytotoxic drugs including leukemias.
Walaupun keberkesanan penggunaan kemoterapi dalam rawatan terhadap pesakit leukimia adalah jelas terbukti, namun leukimia tetap merupakan penyakit yang sukar dirawat terutamanya dalam masalah kerintangan pesakit terhadap ubat-ubatan (dadah).
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