Characterization Of Biomechanical Properties Of Articular Cartilage Across Synovial Joint

Degradation and loss of articular cartilage in synovial joint has long been recognized as the main source of osteoarthritis (OA). It is generally accepted that the biomechanical properties of articular cartilage seem to be more sensitive to pathological changes of the tissue. Extensive studies of ca...

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Main Author:	Jaafar, Yusra Liyana
Format:	Thesis
Language:	English English
Published:	2017
Subjects:	Q Science (General) QP Physiology
Online Access:	http://eprints.utem.edu.my/id/eprint/20617/1/Characterization%20Of%20Biomechanical%20Properties%20Of%20Articular%20Cartilage%20Across%20Synovial%20Joint.pdf http://eprints.utem.edu.my/id/eprint/20617/2/Characterization%20of%20biomechanical%20properties%20of%20articular%20cartilage%20across%20synovial%20joint.pdf
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id	my-utem-ep.20617
record_format	uketd_dc
institution	Universiti Teknikal Malaysia Melaka
collection	UTeM Repository
language	English English
advisor	Abd Latif, Mohd Juzaila
topic	Q Science (General) QP Physiology
spellingShingle	Q Science (General) QP Physiology Jaafar, Yusra Liyana Characterization Of Biomechanical Properties Of Articular Cartilage Across Synovial Joint
description	Degradation and loss of articular cartilage in synovial joint has long been recognized as the main source of osteoarthritis (OA). It is generally accepted that the biomechanical properties of articular cartilage seem to be more sensitive to pathological changes of the tissue. Extensive studies of cartilage have been carried out to characterize the biomechanical properties using both experimental and analytical approaches. These properties were then applied in computational models to investigate the biomechanical behavior of the cartilage. However, analytical analysis was developed based on the theory which idealized the geometrical and physical conditions of the cartilage and subchondral bone. Furthermore, previous experimental studies require the cartilage to be isolated which could possibly damage the cartilage. These could be the main reason as the behavior of the cartilage across the synovial joint is yet to be fully understood because it appears that only part of the cartilage in synovial joint were previously being investigated. Therefore, the study aims to develop new approach to integrate the experimental and computational methods which could enable to characterize the elastic modulus and permeability of the cartilage across the synovial joint. Articular cartilage of bovine humeral head was used to perform the indentation test in order to obtain experimental data. The cartilage was measured using profile projector for development of finite element (FE) model. New approach to integrate the experiment data and FE model were developed to examine the cartilage biphasic elastic modulus and permeability. Based on the result, the elastic modulus increased by 150.6% when cartilage thickness was increase more than twice. Meanwhile, opposite trend was seen for permeability, where the permeability decrease as the cartilage became thicker with 118.9% percentage difference. This could indicate that the actual geometry of cartilage includes of cartilage thickness and curvature does effect the biomechanical properties of articular cartilage across synovial joint. These findings will be serving as a guide in enhancing tissue engineering developments for cartilage repair and as an input for computational studies.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Jaafar, Yusra Liyana
author_facet	Jaafar, Yusra Liyana
author_sort	Jaafar, Yusra Liyana
title	Characterization Of Biomechanical Properties Of Articular Cartilage Across Synovial Joint
title_short	Characterization Of Biomechanical Properties Of Articular Cartilage Across Synovial Joint
title_full	Characterization Of Biomechanical Properties Of Articular Cartilage Across Synovial Joint
title_fullStr	Characterization Of Biomechanical Properties Of Articular Cartilage Across Synovial Joint
title_full_unstemmed	Characterization Of Biomechanical Properties Of Articular Cartilage Across Synovial Joint
title_sort	characterization of biomechanical properties of articular cartilage across synovial joint
granting_institution	Universiti Teknikal Malaysia Melaka
granting_department	Faculty Of Mechanical Engineering
publishDate	2017
url	http://eprints.utem.edu.my/id/eprint/20617/1/Characterization%20Of%20Biomechanical%20Properties%20Of%20Articular%20Cartilage%20Across%20Synovial%20Joint.pdf http://eprints.utem.edu.my/id/eprint/20617/2/Characterization%20of%20biomechanical%20properties%20of%20articular%20cartilage%20across%20synovial%20joint.pdf
_version_	1747833986913140736
spelling	my-utem-ep.206172022-09-08T12:17:49Z Characterization Of Biomechanical Properties Of Articular Cartilage Across Synovial Joint 2017 Jaafar, Yusra Liyana Q Science (General) QP Physiology Degradation and loss of articular cartilage in synovial joint has long been recognized as the main source of osteoarthritis (OA). It is generally accepted that the biomechanical properties of articular cartilage seem to be more sensitive to pathological changes of the tissue. Extensive studies of cartilage have been carried out to characterize the biomechanical properties using both experimental and analytical approaches. These properties were then applied in computational models to investigate the biomechanical behavior of the cartilage. However, analytical analysis was developed based on the theory which idealized the geometrical and physical conditions of the cartilage and subchondral bone. Furthermore, previous experimental studies require the cartilage to be isolated which could possibly damage the cartilage. These could be the main reason as the behavior of the cartilage across the synovial joint is yet to be fully understood because it appears that only part of the cartilage in synovial joint were previously being investigated. Therefore, the study aims to develop new approach to integrate the experimental and computational methods which could enable to characterize the elastic modulus and permeability of the cartilage across the synovial joint. Articular cartilage of bovine humeral head was used to perform the indentation test in order to obtain experimental data. The cartilage was measured using profile projector for development of finite element (FE) model. New approach to integrate the experiment data and FE model were developed to examine the cartilage biphasic elastic modulus and permeability. Based on the result, the elastic modulus increased by 150.6% when cartilage thickness was increase more than twice. Meanwhile, opposite trend was seen for permeability, where the permeability decrease as the cartilage became thicker with 118.9% percentage difference. This could indicate that the actual geometry of cartilage includes of cartilage thickness and curvature does effect the biomechanical properties of articular cartilage across synovial joint. These findings will be serving as a guide in enhancing tissue engineering developments for cartilage repair and as an input for computational studies. 2017 Thesis http://eprints.utem.edu.my/id/eprint/20617/ http://eprints.utem.edu.my/id/eprint/20617/1/Characterization%20Of%20Biomechanical%20Properties%20Of%20Articular%20Cartilage%20Across%20Synovial%20Joint.pdf text en public http://eprints.utem.edu.my/id/eprint/20617/2/Characterization%20of%20biomechanical%20properties%20of%20articular%20cartilage%20across%20synovial%20joint.pdf text en validuser https://plh.utem.edu.my/cgi-bin/koha/opac-detail.pl?biblionumber=106130 mphil masters Universiti Teknikal Malaysia Melaka Faculty Of Mechanical Engineering Abd Latif, Mohd Juzaila 1. Abd Latif, M.J., Jin, Z., and Wilcox, R.K., 2012. Biomechanical Characterisation of OvineSpinal Facet Joint Cartilage. Journal of Biomechanics, 45(8), pp. 1346–1352. 2. Amoako, A., and Pujalte, G.G., 2014. 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