Siam weed based hydrogel hybrid for tissue engineering

Tissue engineered skin grafts have been considered as an auxiliary for replacement of damaged skin due to burns and injury. In previous studies, gelatin hybrid with natural remedy were used in order to create 3D environment for the skin grafts. However, these gelatin hybrids were not sufficien...

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Main Author:	Mohamed, Nor Shamsiah
Format:	Thesis
Language:	English English English
Published:	2020
Subjects:	R856-857 Biomedical engineering Electronics Instrumentation
Online Access:	http://eprints.uthm.edu.my/1052/1/24p%20NOR%20SHAMSIAH%20MOHAMED.pdf http://eprints.uthm.edu.my/1052/2/NOR%20SHAMSIAH%20MOHAMED%20COPYRIGHT%20DECLARATION.pdf http://eprints.uthm.edu.my/1052/3/NOR%20SHAMSIAH%20MOHAMED%20WATERMARK.pdf
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id	my-uthm-ep.1052
record_format	uketd_dc
spelling	my-uthm-ep.10522021-09-21T05:00:20Z Siam weed based hydrogel hybrid for tissue engineering 2020-02 Mohamed, Nor Shamsiah R856-857 Biomedical engineering. Electronics. Instrumentation Tissue engineered skin grafts have been considered as an auxiliary for replacement of damaged skin due to burns and injury. In previous studies, gelatin hybrid with natural remedy were used in order to create 3D environment for the skin grafts. However, these gelatin hybrids were not sufficient to promote the healing process especially for infected wounds due to lack of therapeutic properties and their mechanical properties are yet to be defined. In this research, Siam Weed therapeutic properties promote healing process and its mechanical properties were enhanced by gelatin and electrospinning technique to produce Siam weed-gelatin electrospun scaffold as a successful 3D skin tissue engineering grafts. The effects of content of Siam weed extracts on the electrospun scaffolds are determined using scanning electron microscopy, Fourier Transfom Infrared spectroscopy and degradation study of solution properties. The results indicated that concentration affects the solution properties such as viscosity, conductivity and ultimately the fiber diameter. The fibrous meshes were then crosslinked with glutaraldehyde vapor and its mechanical properties were determined by tensile . The value of tensile strength of the crosslinked fibrous scaffold was higher than that of human skin proving that it has high potential to be a successful skin graft when immobilized at the wound site. Cell proliferation study of the Siam weed extracts indicated that the extracts had significantly stimulate cell proliferation with a strong response at the concentration of 25 µg/ml therefore giving the optimum proliferation of the cells. The results implied the possibility of using Siam weed-gelatin fibrous scaffold as a promising candidate for tissue engineered skin grafts 2020-02 Thesis http://eprints.uthm.edu.my/1052/ http://eprints.uthm.edu.my/1052/1/24p%20NOR%20SHAMSIAH%20MOHAMED.pdf text en public http://eprints.uthm.edu.my/1052/2/NOR%20SHAMSIAH%20MOHAMED%20COPYRIGHT%20DECLARATION.pdf text en staffonly http://eprints.uthm.edu.my/1052/3/NOR%20SHAMSIAH%20MOHAMED%20WATERMARK.pdf text en validuser mphil masters Universiti Tun Hussein Onn Malaysia Fakulti Kejuruteraan Mekanikal dan Pembuatan
institution	Universiti Tun Hussein Onn Malaysia
collection	UTHM Institutional Repository
language	English English English
topic	R856-857 Biomedical engineering Electronics Instrumentation
spellingShingle	R856-857 Biomedical engineering Electronics Instrumentation Mohamed, Nor Shamsiah Siam weed based hydrogel hybrid for tissue engineering
description	Tissue engineered skin grafts have been considered as an auxiliary for replacement of damaged skin due to burns and injury. In previous studies, gelatin hybrid with natural remedy were used in order to create 3D environment for the skin grafts. However, these gelatin hybrids were not sufficient to promote the healing process especially for infected wounds due to lack of therapeutic properties and their mechanical properties are yet to be defined. In this research, Siam Weed therapeutic properties promote healing process and its mechanical properties were enhanced by gelatin and electrospinning technique to produce Siam weed-gelatin electrospun scaffold as a successful 3D skin tissue engineering grafts. The effects of content of Siam weed extracts on the electrospun scaffolds are determined using scanning electron microscopy, Fourier Transfom Infrared spectroscopy and degradation study of solution properties. The results indicated that concentration affects the solution properties such as viscosity, conductivity and ultimately the fiber diameter. The fibrous meshes were then crosslinked with glutaraldehyde vapor and its mechanical properties were determined by tensile . The value of tensile strength of the crosslinked fibrous scaffold was higher than that of human skin proving that it has high potential to be a successful skin graft when immobilized at the wound site. Cell proliferation study of the Siam weed extracts indicated that the extracts had significantly stimulate cell proliferation with a strong response at the concentration of 25 µg/ml therefore giving the optimum proliferation of the cells. The results implied the possibility of using Siam weed-gelatin fibrous scaffold as a promising candidate for tissue engineered skin grafts
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Mohamed, Nor Shamsiah
author_facet	Mohamed, Nor Shamsiah
author_sort	Mohamed, Nor Shamsiah
title	Siam weed based hydrogel hybrid for tissue engineering
title_short	Siam weed based hydrogel hybrid for tissue engineering
title_full	Siam weed based hydrogel hybrid for tissue engineering
title_fullStr	Siam weed based hydrogel hybrid for tissue engineering
title_full_unstemmed	Siam weed based hydrogel hybrid for tissue engineering
title_sort	siam weed based hydrogel hybrid for tissue engineering
granting_institution	Universiti Tun Hussein Onn Malaysia
granting_department	Fakulti Kejuruteraan Mekanikal dan Pembuatan
publishDate	2020
url	http://eprints.uthm.edu.my/1052/1/24p%20NOR%20SHAMSIAH%20MOHAMED.pdf http://eprints.uthm.edu.my/1052/2/NOR%20SHAMSIAH%20MOHAMED%20COPYRIGHT%20DECLARATION.pdf http://eprints.uthm.edu.my/1052/3/NOR%20SHAMSIAH%20MOHAMED%20WATERMARK.pdf
_version_	1747830731205246976

Siam weed based hydrogel hybrid for tissue engineering

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