Preparation and characterization of poly (methyl methacrylate)-silver nanoparticles polymer composite as a dental prosthesis

Silver nanoparticles (AgNPs) have been used for centuries in the field of medicine due to the its antimicrobial properties. AgNPs had been synthesized and incorporated in different aspects of biomaterials. According to previous studies, AgNPs provides sufficient antimicrobial effect at lower filler...

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Main Author:	Bendjama, Adel
Format:	Thesis
Language:	English English English
Published:	2023
Subjects:	RK Dentistry
Online Access:	http://eprints.uthm.edu.my/10970/1/24p%20ADEL%20BENDJAMA.pdf http://eprints.uthm.edu.my/10970/2/ADEL%20BENDJAMA%20COPYRIGHT%20DECLARATION.pdf http://eprints.uthm.edu.my/10970/3/ADEL%20BENDJAMA%20WATERMARK.pdf
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spelling	my-uthm-ep.109702024-05-15T07:21:56Z Preparation and characterization of poly (methyl methacrylate)-silver nanoparticles polymer composite as a dental prosthesis 2023-01 Bendjama, Adel RK Dentistry Silver nanoparticles (AgNPs) have been used for centuries in the field of medicine due to the its antimicrobial properties. AgNPs had been synthesized and incorporated in different aspects of biomaterials. According to previous studies, AgNPs provides sufficient antimicrobial effect at lower filler level by increasing membrane permeability and destroying bacteria due to its small size. Therefore, AgNPs can be used in dentistry towards prevention and reduction of biofilm formation on the surfaces of dental prosthesis. The main objective of this study is to synthesize poly (methyl methacrylate)-silver nanoparticles antimicrobial acrylic resin for dental prosthesis. The antibacterial effect of the AgNPs incorporated into acrylic resin poly methyl methacrylate (PMMA) was studied and the incorporating effects on the thermal stability of these polymeric biocides were evaluated. Colloidal AgNPs were added to PMMA (ONDA-CRYL) with different concentration (0.021 mg/ml, 0.0525 mg/ml, 0.084 mg/ml). The antimicrobial activity of the silver nanoparticle incorporated into PMMA was measured using disk diffusion method. Thermal stability, morphological and average size, and size distribution of AgNPs/PMMA were determined by transmission electron microscope, scanning electron microscope, and X-ray diffraction. The thermal stability and the glass transition temperature of the four samples were determined by using the thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) analysis. From this study, it was found that the modified PMMA prosthesis base containing 0.084 mg/ml of AgNPs (S3) significantly exhibited antimicrobial properties in vitro, where the number of biofilm bacteria formed is 1.104/ml comparing with the control sample (S0). The incorporation of AgNPs at concentration 0.084 mg/ml to PMMA shows thermal stability at temperature of 350oC-370oC without altering their mechanical properties. Therefore, the AgNPs-PMMA nanocomposite could be used as a dental prosthesis 2023-01 Thesis http://eprints.uthm.edu.my/10970/ http://eprints.uthm.edu.my/10970/1/24p%20ADEL%20BENDJAMA.pdf text en public http://eprints.uthm.edu.my/10970/2/ADEL%20BENDJAMA%20COPYRIGHT%20DECLARATION.pdf text en staffonly http://eprints.uthm.edu.my/10970/3/ADEL%20BENDJAMA%20WATERMARK.pdf text en validuser mphil masters Universiti Tun Hussein Onn Malaysia Fakulti Sains Gunaan dan Teknologi
institution	Universiti Tun Hussein Onn Malaysia
collection	UTHM Institutional Repository
language	English English English
topic	RK Dentistry
spellingShingle	RK Dentistry Bendjama, Adel Preparation and characterization of poly (methyl methacrylate)-silver nanoparticles polymer composite as a dental prosthesis
description	Silver nanoparticles (AgNPs) have been used for centuries in the field of medicine due to the its antimicrobial properties. AgNPs had been synthesized and incorporated in different aspects of biomaterials. According to previous studies, AgNPs provides sufficient antimicrobial effect at lower filler level by increasing membrane permeability and destroying bacteria due to its small size. Therefore, AgNPs can be used in dentistry towards prevention and reduction of biofilm formation on the surfaces of dental prosthesis. The main objective of this study is to synthesize poly (methyl methacrylate)-silver nanoparticles antimicrobial acrylic resin for dental prosthesis. The antibacterial effect of the AgNPs incorporated into acrylic resin poly methyl methacrylate (PMMA) was studied and the incorporating effects on the thermal stability of these polymeric biocides were evaluated. Colloidal AgNPs were added to PMMA (ONDA-CRYL) with different concentration (0.021 mg/ml, 0.0525 mg/ml, 0.084 mg/ml). The antimicrobial activity of the silver nanoparticle incorporated into PMMA was measured using disk diffusion method. Thermal stability, morphological and average size, and size distribution of AgNPs/PMMA were determined by transmission electron microscope, scanning electron microscope, and X-ray diffraction. The thermal stability and the glass transition temperature of the four samples were determined by using the thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) analysis. From this study, it was found that the modified PMMA prosthesis base containing 0.084 mg/ml of AgNPs (S3) significantly exhibited antimicrobial properties in vitro, where the number of biofilm bacteria formed is 1.104/ml comparing with the control sample (S0). The incorporation of AgNPs at concentration 0.084 mg/ml to PMMA shows thermal stability at temperature of 350oC-370oC without altering their mechanical properties. Therefore, the AgNPs-PMMA nanocomposite could be used as a dental prosthesis
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Bendjama, Adel
author_facet	Bendjama, Adel
author_sort	Bendjama, Adel
title	Preparation and characterization of poly (methyl methacrylate)-silver nanoparticles polymer composite as a dental prosthesis
title_short	Preparation and characterization of poly (methyl methacrylate)-silver nanoparticles polymer composite as a dental prosthesis
title_full	Preparation and characterization of poly (methyl methacrylate)-silver nanoparticles polymer composite as a dental prosthesis
title_fullStr	Preparation and characterization of poly (methyl methacrylate)-silver nanoparticles polymer composite as a dental prosthesis
title_full_unstemmed	Preparation and characterization of poly (methyl methacrylate)-silver nanoparticles polymer composite as a dental prosthesis
title_sort	preparation and characterization of poly (methyl methacrylate)-silver nanoparticles polymer composite as a dental prosthesis
granting_institution	Universiti Tun Hussein Onn Malaysia
granting_department	Fakulti Sains Gunaan dan Teknologi
publishDate	2023
url	http://eprints.uthm.edu.my/10970/1/24p%20ADEL%20BENDJAMA.pdf http://eprints.uthm.edu.my/10970/2/ADEL%20BENDJAMA%20COPYRIGHT%20DECLARATION.pdf http://eprints.uthm.edu.my/10970/3/ADEL%20BENDJAMA%20WATERMARK.pdf
_version_	1804890127864954880

Preparation and characterization of poly (methyl methacrylate)-silver nanoparticles polymer composite as a dental prosthesis

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