A study of factors affecting the occurrence of down syndrome in Negeri Sembilan Malaysia

Due to the fact of the high correlation between advanced maternal age and the risk of Down syndrome, genetic and socio- demographic factors of population are expected to have considerable effect on Down syndrome births. The main objective of this research was to assess the effect of genetic an...

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Main Author:	Chigozie, Opara Otuodi
Format:	Thesis
Language:	English English English
Published:	2020
Subjects:	RJ370-550 Diseases of children and adolescents
Online Access:	http://eprints.uthm.edu.my/1148/1/24p%20OPARA%20OTUODI%20CHIGOZIE.pdf http://eprints.uthm.edu.my/1148/2/OPARA%20OTUODI%20CHIGOZIE%20COPYRIGHT%20DECLRATION.pdf http://eprints.uthm.edu.my/1148/3/OPARA%20OTUODI%20CHIGOZIE%20WATERMARK.pdf
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id	my-uthm-ep.1148
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spelling	my-uthm-ep.11482021-09-30T05:16:51Z A study of factors affecting the occurrence of down syndrome in Negeri Sembilan Malaysia 2020-07 Chigozie, Opara Otuodi RJ370-550 Diseases of children and adolescents Due to the fact of the high correlation between advanced maternal age and the risk of Down syndrome, genetic and socio- demographic factors of population are expected to have considerable effect on Down syndrome births. The main objective of this research was to assess the effect of genetic and socio-demographic factors within Malaysia in number and incidences of DS. Three hypothesis were tested using 104 DS data and 204 NDS data in Negeri Sembilan, obtained through questionnaire. The hypothesis tested included whether there is a relationship between DS cases and advanced maternal age in Malaysian population, whether there is relationship between genetic factors and DS cases in Malaysian population and lastly whether there is a relationship between DS cases and certain socio-demographic factors in the Malaysian population. Regression analysis having become a standard statistical tool for analysis, probit model, linear probability model and multiple logistic model were used for analysing DS data against genetic and socio-demographic variables while simple logit and probit models were used to analyze DS data against maternal age. For each analysis, these models were compared using Akaike information criteria to determine the model with the best fit for prediction. The results show a significant relationship between maternal age and DS cases. It was also found that DS is not genetic and cannot be transferred from parent to offspring. Race, place of residence and mothers’ education level were found to have significant influence on occurrence of DS in Malaysia. Paternal age, Smoking habit, pre-natal scan, and heredity were found to be insignificant factors in the occurrence of DS in Malaysia 2020-07 Thesis http://eprints.uthm.edu.my/1148/ http://eprints.uthm.edu.my/1148/1/24p%20OPARA%20OTUODI%20CHIGOZIE.pdf text en public http://eprints.uthm.edu.my/1148/2/OPARA%20OTUODI%20CHIGOZIE%20COPYRIGHT%20DECLRATION.pdf text en staffonly http://eprints.uthm.edu.my/1148/3/OPARA%20OTUODI%20CHIGOZIE%20WATERMARK.pdf text en validuser mphil masters Universiti Tun Hussein Onn Malaysia Fakulti Sains Gunaan dan Teknologi
institution	Universiti Tun Hussein Onn Malaysia
collection	UTHM Institutional Repository
language	English English English
topic	RJ370-550 Diseases of children and adolescents
spellingShingle	RJ370-550 Diseases of children and adolescents Chigozie, Opara Otuodi A study of factors affecting the occurrence of down syndrome in Negeri Sembilan Malaysia
description	Due to the fact of the high correlation between advanced maternal age and the risk of Down syndrome, genetic and socio- demographic factors of population are expected to have considerable effect on Down syndrome births. The main objective of this research was to assess the effect of genetic and socio-demographic factors within Malaysia in number and incidences of DS. Three hypothesis were tested using 104 DS data and 204 NDS data in Negeri Sembilan, obtained through questionnaire. The hypothesis tested included whether there is a relationship between DS cases and advanced maternal age in Malaysian population, whether there is relationship between genetic factors and DS cases in Malaysian population and lastly whether there is a relationship between DS cases and certain socio-demographic factors in the Malaysian population. Regression analysis having become a standard statistical tool for analysis, probit model, linear probability model and multiple logistic model were used for analysing DS data against genetic and socio-demographic variables while simple logit and probit models were used to analyze DS data against maternal age. For each analysis, these models were compared using Akaike information criteria to determine the model with the best fit for prediction. The results show a significant relationship between maternal age and DS cases. It was also found that DS is not genetic and cannot be transferred from parent to offspring. Race, place of residence and mothers’ education level were found to have significant influence on occurrence of DS in Malaysia. Paternal age, Smoking habit, pre-natal scan, and heredity were found to be insignificant factors in the occurrence of DS in Malaysia
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Chigozie, Opara Otuodi
author_facet	Chigozie, Opara Otuodi
author_sort	Chigozie, Opara Otuodi
title	A study of factors affecting the occurrence of down syndrome in Negeri Sembilan Malaysia
title_short	A study of factors affecting the occurrence of down syndrome in Negeri Sembilan Malaysia
title_full	A study of factors affecting the occurrence of down syndrome in Negeri Sembilan Malaysia
title_fullStr	A study of factors affecting the occurrence of down syndrome in Negeri Sembilan Malaysia
title_full_unstemmed	A study of factors affecting the occurrence of down syndrome in Negeri Sembilan Malaysia
title_sort	study of factors affecting the occurrence of down syndrome in negeri sembilan malaysia
granting_institution	Universiti Tun Hussein Onn Malaysia
granting_department	Fakulti Sains Gunaan dan Teknologi
publishDate	2020
url	http://eprints.uthm.edu.my/1148/1/24p%20OPARA%20OTUODI%20CHIGOZIE.pdf http://eprints.uthm.edu.my/1148/2/OPARA%20OTUODI%20CHIGOZIE%20COPYRIGHT%20DECLRATION.pdf http://eprints.uthm.edu.my/1148/3/OPARA%20OTUODI%20CHIGOZIE%20WATERMARK.pdf
_version_	1747830745180667904

A study of factors affecting the occurrence of down syndrome in Negeri Sembilan Malaysia

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