Magnesium doped calcium phosphate sodium alginate biocomposite for bone implant application

Calcium phosphate (CaP) usually been used for bone implant application due to the similarity mineral in natural bone and it is bioactive and biocompatible material. However, CaP has low mechanical strength under load bearing condition and limited on certain application only. Therefore, sodium algina...

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Main Author:	Mustaffa, Nor Azimah
Format:	Thesis
Language:	English English
Published:	2018
Subjects:	T Technology (General)
Online Access:	http://eprints.uthm.edu.my/480/1/24p%20NOR%20AZIMAH%20MUSTAFFA.pdf http://eprints.uthm.edu.my/480/2/NOR%20AZIMAH%20MUSTAFFA%20WATERMARK.pdf
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spelling	my-uthm-ep.4802022-08-09T03:14:21Z Magnesium doped calcium phosphate sodium alginate biocomposite for bone implant application 2018-04 Mustaffa, Nor Azimah T Technology (General) Calcium phosphate (CaP) usually been used for bone implant application due to the similarity mineral in natural bone and it is bioactive and biocompatible material. However, CaP has low mechanical strength under load bearing condition and limited on certain application only. Therefore, sodium alginate (SA), a natural polymer is combined with CaP and doped with magnesium (Mg) to improve the properties of the CaP. CaP/SA biocomposite was successfully prepared by using precipitation method with different ratio of CaP/SA (100/0, 99/1, 97/3, 95/5, 90/10, and 80/20). 95/5 ratio of CaP/SA which the optimum properties of density, hardness, and microstructure analysis was selected to doped with Mg. The composite was then doped with different weight percentage of Mg (0 wt%, 1.0 wt%, 1.5 wt%, and 2.0 wt%) by using similar method. From FTIR analysis, the addition of Mg in CaP was observed decreasing the phosphate group intensity due to substitution of Mg in CaP that also supported in XRD analysis where new phase was formed in Mg doping that belongs to Mg-whitlockite (Ca2.71Mg0.29(PO4)2. Furthermore, the addition of SA and Mg was confirmed by EDS analysis where the mass percentage of these elements were increased as increasing the SA and Mg content. Microstructure from SEM has shown formation small and large grain with average grain size obtained 2.61 μm which leds to the strong bonding resulted maximum hardness at 5.34GPa after doped with 1.5wt%. The density also improved at similar weight percentage with 2.92g/cm3. From the result, 1.5wt% Mg that has been doped with 95/5 CaP/SA was showed the best combination based on physical and mechanical properties. 2018-04 Thesis http://eprints.uthm.edu.my/480/ http://eprints.uthm.edu.my/480/1/24p%20NOR%20AZIMAH%20MUSTAFFA.pdf text en public http://eprints.uthm.edu.my/480/2/NOR%20AZIMAH%20MUSTAFFA%20WATERMARK.pdf text en validuser mphil masters Universiti Tun Hussein Onn Malaysia Faculty of Mechanical and Manufacturing Engineering
institution	Universiti Tun Hussein Onn Malaysia
collection	UTHM Institutional Repository
language	English English
topic	T Technology (General)
spellingShingle	T Technology (General) Mustaffa, Nor Azimah Magnesium doped calcium phosphate sodium alginate biocomposite for bone implant application
description	Calcium phosphate (CaP) usually been used for bone implant application due to the similarity mineral in natural bone and it is bioactive and biocompatible material. However, CaP has low mechanical strength under load bearing condition and limited on certain application only. Therefore, sodium alginate (SA), a natural polymer is combined with CaP and doped with magnesium (Mg) to improve the properties of the CaP. CaP/SA biocomposite was successfully prepared by using precipitation method with different ratio of CaP/SA (100/0, 99/1, 97/3, 95/5, 90/10, and 80/20). 95/5 ratio of CaP/SA which the optimum properties of density, hardness, and microstructure analysis was selected to doped with Mg. The composite was then doped with different weight percentage of Mg (0 wt%, 1.0 wt%, 1.5 wt%, and 2.0 wt%) by using similar method. From FTIR analysis, the addition of Mg in CaP was observed decreasing the phosphate group intensity due to substitution of Mg in CaP that also supported in XRD analysis where new phase was formed in Mg doping that belongs to Mg-whitlockite (Ca2.71Mg0.29(PO4)2. Furthermore, the addition of SA and Mg was confirmed by EDS analysis where the mass percentage of these elements were increased as increasing the SA and Mg content. Microstructure from SEM has shown formation small and large grain with average grain size obtained 2.61 μm which leds to the strong bonding resulted maximum hardness at 5.34GPa after doped with 1.5wt%. The density also improved at similar weight percentage with 2.92g/cm3. From the result, 1.5wt% Mg that has been doped with 95/5 CaP/SA was showed the best combination based on physical and mechanical properties.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Mustaffa, Nor Azimah
author_facet	Mustaffa, Nor Azimah
author_sort	Mustaffa, Nor Azimah
title	Magnesium doped calcium phosphate sodium alginate biocomposite for bone implant application
title_short	Magnesium doped calcium phosphate sodium alginate biocomposite for bone implant application
title_full	Magnesium doped calcium phosphate sodium alginate biocomposite for bone implant application
title_fullStr	Magnesium doped calcium phosphate sodium alginate biocomposite for bone implant application
title_full_unstemmed	Magnesium doped calcium phosphate sodium alginate biocomposite for bone implant application
title_sort	magnesium doped calcium phosphate sodium alginate biocomposite for bone implant application
granting_institution	Universiti Tun Hussein Onn Malaysia
granting_department	Faculty of Mechanical and Manufacturing Engineering
publishDate	2018
url	http://eprints.uthm.edu.my/480/1/24p%20NOR%20AZIMAH%20MUSTAFFA.pdf http://eprints.uthm.edu.my/480/2/NOR%20AZIMAH%20MUSTAFFA%20WATERMARK.pdf
_version_	1747830620447309824

Magnesium doped calcium phosphate sodium alginate biocomposite for bone implant application

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