Development of electrospinning machine for the production of homogeneous and functionally graded multilayer polymeric nanofibers
Electrospinning technology has been widely used in producing porous scaffolds consisting of nano- to microfibers. These porous electrospun scaffolds are useful in various applications including medical and filtration applications. The microstructure architecture such as pore size and fiber diam...
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| Format: | Thesis |
| Language: | English English English |
| Published: |
2022
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| Subjects: | |
| Online Access: | http://eprints.uthm.edu.my/8273/1/24p%20LIM%20SHING%20CHEE.pdf http://eprints.uthm.edu.my/8273/2/LIM%20SHING%20CHEE%20COPYRIGHT%20DECLARATION.pdf http://eprints.uthm.edu.my/8273/3/LIM%20SHING%20CHEE%20WATERMARK.pdf |
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| Summary: | Electrospinning technology has been widely used in producing porous scaffolds
consisting of nano- to microfibers. These porous electrospun scaffolds are useful in
various applications including medical and filtration applications. The microstructure
architecture such as pore size and fiber diameter is able to affect their function and
efficiency. In medical applications, the control of pore sizes affects the environment
to promote cellular activities. For filtration applications, the pore size can control
filtration efficiency. The control of microstructure architecture, however, is a
difficult task due to the microstructure of the electrospun being highly sensitive to
the electrospinning parameters. One way to manipulate the microstructure
architecture is by governing the process parameter and the knowledge in developing
electrospinning machines brings the potential to develop novel electrospun scaffolds.
This thesis focuses on the design and fabrication of the electrospinning machine. The
machine was used to produce gelatin nanofibers with tailored microstructures and
functionally graded multilayers. First, an electrospinning machine consists a high
voltage supply, a syringe pump and a collector was built to produce homogeneous
electrospun scaffolds. Gelatin and Polycaprolactone were spun into porous fibrous
networks. The relationship between process parameters and microstructures was
studied. These process parameters and microstructure dataset were used to produce
the functionally graded multilayer electrospun gelatin scaffolds. A controllable
moving stage was developed to precisely control the tip-collector distance and
microstructure gradient over scaffold thickness. Microstructure images of
functionally graded multilayers electrospun scaffold show the gradual changes of
fiber diameters in nano-sized over the scaffold thickness. This study proposes a novel
technique for designing the graded electrospun scaffolds which more closely mimic
the native tissues. |
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