Hardware implementation for cardiac electrical excitation and conduction using an FPGA

Contraction of the heart is controlled by electrical excitations of cardiac cell membranes. The electrical excitations of the cells and their propagation in the heart tissue provide a basis of the physiological function of the heart through the cardiac excitation-conduction mechanism. One way to und...

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Main Author:	Adon, Nur Atiqah
Format:	Thesis
Language:	English English
Published:	2017
Subjects:	QP1-345 Physiology General
Online Access:	http://eprints.uthm.edu.my/848/1/24p%20NUR%20ATIQAH%20ADON.pdf http://eprints.uthm.edu.my/848/2/NUR%20ATIQAH%20ADON%20WATERMARK.pdf
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spelling	my-uthm-ep.8482021-09-06T04:22:34Z Hardware implementation for cardiac electrical excitation and conduction using an FPGA 2017-01 Adon, Nur Atiqah QP1-345 Physiology General Contraction of the heart is controlled by electrical excitations of cardiac cell membranes. The electrical excitations of the cells and their propagation in the heart tissue provide a basis of the physiological function of the heart through the cardiac excitation-conduction mechanism. One way to understand normal and abnormal dynamics of the heart is to simulate a comprehensive mathematical model of the cardiac excitation in order to study underlying mechanisms of the heart electrical system. However, simulating the dynamics of large numbers of a cellular model to form a tissue model requires an immense amount of computational time. In order to reduce the computational time required for the simulation, a hardware implementation of cardiac electrical excitation-conduction analysis system has been developed based on FitzHugh-Nagumo (FHN) model for a mammalian cardiac ventricular cell. In this research, one dimensional (1D) ring-shaped cable model with 80 compartments of the cell model designed using MATLAB Simulink blocks is able to be converted into synthesizable VHSIC (Very High Speed Integrated Circuit) of Hardware Description Language (VHDL) code by using an FPGA-based rapid-prototyping approach of MATLAB HDL Coder in order to simulate an action potential signal and its conduction through a hardware-implemented Field Programmable Gate Array (FPGA). Then, the VHDL design is functionally verified on an FPGA Xilinx Virtex-6 board using MATLAB HDL Verifier through FPGA-in-the-Loop (FIL) simulation approach. Simulations of cardiac cellular processes and reentrant arrhythmia are successfully conducted on Xilinx Chipscope Pro. High accuracy results have been obtained from the FPGA-on-board simulation compared to a software-based computer simulation with Percentage Error (PE) of 1.28% and 1.56% in performing the simulations of reentrant initiation and annihilation, respectively. The simulations are also capable to run in real time. 2017-01 Thesis http://eprints.uthm.edu.my/848/ http://eprints.uthm.edu.my/848/1/24p%20NUR%20ATIQAH%20ADON.pdf text en public http://eprints.uthm.edu.my/848/2/NUR%20ATIQAH%20ADON%20WATERMARK.pdf text en validuser mphil masters Universiti Tun Hussein Onn Malaysia Fakulti Kejuruteraan Elektrik dan Elektronik
institution	Universiti Tun Hussein Onn Malaysia
collection	UTHM Institutional Repository
language	English English
topic	QP1-345 Physiology General
spellingShingle	QP1-345 Physiology General Adon, Nur Atiqah Hardware implementation for cardiac electrical excitation and conduction using an FPGA
description	Contraction of the heart is controlled by electrical excitations of cardiac cell membranes. The electrical excitations of the cells and their propagation in the heart tissue provide a basis of the physiological function of the heart through the cardiac excitation-conduction mechanism. One way to understand normal and abnormal dynamics of the heart is to simulate a comprehensive mathematical model of the cardiac excitation in order to study underlying mechanisms of the heart electrical system. However, simulating the dynamics of large numbers of a cellular model to form a tissue model requires an immense amount of computational time. In order to reduce the computational time required for the simulation, a hardware implementation of cardiac electrical excitation-conduction analysis system has been developed based on FitzHugh-Nagumo (FHN) model for a mammalian cardiac ventricular cell. In this research, one dimensional (1D) ring-shaped cable model with 80 compartments of the cell model designed using MATLAB Simulink blocks is able to be converted into synthesizable VHSIC (Very High Speed Integrated Circuit) of Hardware Description Language (VHDL) code by using an FPGA-based rapid-prototyping approach of MATLAB HDL Coder in order to simulate an action potential signal and its conduction through a hardware-implemented Field Programmable Gate Array (FPGA). Then, the VHDL design is functionally verified on an FPGA Xilinx Virtex-6 board using MATLAB HDL Verifier through FPGA-in-the-Loop (FIL) simulation approach. Simulations of cardiac cellular processes and reentrant arrhythmia are successfully conducted on Xilinx Chipscope Pro. High accuracy results have been obtained from the FPGA-on-board simulation compared to a software-based computer simulation with Percentage Error (PE) of 1.28% and 1.56% in performing the simulations of reentrant initiation and annihilation, respectively. The simulations are also capable to run in real time.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Adon, Nur Atiqah
author_facet	Adon, Nur Atiqah
author_sort	Adon, Nur Atiqah
title	Hardware implementation for cardiac electrical excitation and conduction using an FPGA
title_short	Hardware implementation for cardiac electrical excitation and conduction using an FPGA
title_full	Hardware implementation for cardiac electrical excitation and conduction using an FPGA
title_fullStr	Hardware implementation for cardiac electrical excitation and conduction using an FPGA
title_full_unstemmed	Hardware implementation for cardiac electrical excitation and conduction using an FPGA
title_sort	hardware implementation for cardiac electrical excitation and conduction using an fpga
granting_institution	Universiti Tun Hussein Onn Malaysia
granting_department	Fakulti Kejuruteraan Elektrik dan Elektronik
publishDate	2017
url	http://eprints.uthm.edu.my/848/1/24p%20NUR%20ATIQAH%20ADON.pdf http://eprints.uthm.edu.my/848/2/NUR%20ATIQAH%20ADON%20WATERMARK.pdf
_version_	1747830692975214592

Hardware implementation for cardiac electrical excitation and conduction using an FPGA

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