Synergistic cytotoxic effect of thymoquinone in combination with cisplatin against MDA-MB-231 triple negative cell line

The purpose of this study is to investigate the application of genetic algorithm (GA) in modelling linear and non-linear dynamic systems and develop an alternative model structure selection algorithm based on GA. Orthogonal least square (OLS), a gradient descent method was used as the benchmark for...

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Main Author:	Zolkemri, Zurfarahanim
Format:	Thesis
Language:	English
Published:	2020
Subjects:	Q Science (General)
Online Access:	http://eprints.utm.my/id/eprint/102041/1/ZurfarahanimZolkemriMFS2020.pdf
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id	my-utm-ep.102041
record_format	uketd_dc
spelling	my-utm-ep.1020412023-07-31T07:17:56Z Synergistic cytotoxic effect of thymoquinone in combination with cisplatin against MDA-MB-231 triple negative cell line 2020 Zolkemri, Zurfarahanim Q Science (General) The purpose of this study is to investigate the application of genetic algorithm (GA) in modelling linear and non-linear dynamic systems and develop an alternative model structure selection algorithm based on GA. Orthogonal least square (OLS), a gradient descent method was used as the benchmark for the proposed algorithm. A model structure selection based on modified genetic algorithm (MGA) has been proposed in this study to reduce problems of premature convergence in simple GA (SGA). The effect of different combinations of MGA operators on the performance of the developed model was studied and the effectiveness and shortcomings of MGA were highlighted. Results were compared between SGA, MGA and benchmark OLS method. It was discovered that with similar number of dynamic terms, in most cases, MGA performs better than SGA in terms of exploring potential solution and outperformed the OLS algorithm in terms of selected number of terms and predictive accuracy. In addition, the use of local search with MGA for fine-tuning the algorithm was also proposed and investigated, named as memetic algorithm (MA). Simulation results demonstrated that in most cases, MA is able to produce an adequate and parsimonious model that can satisfy the model validation tests with significant advantages over OLS, SGA and MGA methods. Furthermore, the case studies on identification of multivariable systems based on real experiment t al data from two systems namely a turbo alternator and a continuous stirred tank reactor showed that the proposed algorithm could be used as an alternative to adequately identify adequate and parsimonious models for those systems. Abstract must be bilingual. For a thesis written in Bahasa Melayu, the abstract must first be written in Bahasa Melayu and followed by the English translation. If the thesis is written in English, the abstract must be written in English and followed by the translation in Bahasa Melayu. The abstract should be brief, written in one paragraph and not exceed one (1) page. An abstract is different from synopsis or summary of a thesis. It should states the field of study, problem definition, methodology adopted, research process, results obtained and conclusion of the research. The abstract can be written using single or one and a half spacing. Example can be seen in Appendix 1 (Bahasa Melayu) and Appendix J (English). 2020 Thesis http://eprints.utm.my/id/eprint/102041/ http://eprints.utm.my/id/eprint/102041/1/ZurfarahanimZolkemriMFS2020.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:146308 masters Universiti Teknologi Malaysia, Faculty of Science Faculty of Science
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Zolkemri, Zurfarahanim Synergistic cytotoxic effect of thymoquinone in combination with cisplatin against MDA-MB-231 triple negative cell line
description	The purpose of this study is to investigate the application of genetic algorithm (GA) in modelling linear and non-linear dynamic systems and develop an alternative model structure selection algorithm based on GA. Orthogonal least square (OLS), a gradient descent method was used as the benchmark for the proposed algorithm. A model structure selection based on modified genetic algorithm (MGA) has been proposed in this study to reduce problems of premature convergence in simple GA (SGA). The effect of different combinations of MGA operators on the performance of the developed model was studied and the effectiveness and shortcomings of MGA were highlighted. Results were compared between SGA, MGA and benchmark OLS method. It was discovered that with similar number of dynamic terms, in most cases, MGA performs better than SGA in terms of exploring potential solution and outperformed the OLS algorithm in terms of selected number of terms and predictive accuracy. In addition, the use of local search with MGA for fine-tuning the algorithm was also proposed and investigated, named as memetic algorithm (MA). Simulation results demonstrated that in most cases, MA is able to produce an adequate and parsimonious model that can satisfy the model validation tests with significant advantages over OLS, SGA and MGA methods. Furthermore, the case studies on identification of multivariable systems based on real experiment t al data from two systems namely a turbo alternator and a continuous stirred tank reactor showed that the proposed algorithm could be used as an alternative to adequately identify adequate and parsimonious models for those systems. Abstract must be bilingual. For a thesis written in Bahasa Melayu, the abstract must first be written in Bahasa Melayu and followed by the English translation. If the thesis is written in English, the abstract must be written in English and followed by the translation in Bahasa Melayu. The abstract should be brief, written in one paragraph and not exceed one (1) page. An abstract is different from synopsis or summary of a thesis. It should states the field of study, problem definition, methodology adopted, research process, results obtained and conclusion of the research. The abstract can be written using single or one and a half spacing. Example can be seen in Appendix 1 (Bahasa Melayu) and Appendix J (English).
format	Thesis
qualification_level	Master's degree
author	Zolkemri, Zurfarahanim
author_facet	Zolkemri, Zurfarahanim
author_sort	Zolkemri, Zurfarahanim
title	Synergistic cytotoxic effect of thymoquinone in combination with cisplatin against MDA-MB-231 triple negative cell line
title_short	Synergistic cytotoxic effect of thymoquinone in combination with cisplatin against MDA-MB-231 triple negative cell line
title_full	Synergistic cytotoxic effect of thymoquinone in combination with cisplatin against MDA-MB-231 triple negative cell line
title_fullStr	Synergistic cytotoxic effect of thymoquinone in combination with cisplatin against MDA-MB-231 triple negative cell line
title_full_unstemmed	Synergistic cytotoxic effect of thymoquinone in combination with cisplatin against MDA-MB-231 triple negative cell line
title_sort	synergistic cytotoxic effect of thymoquinone in combination with cisplatin against mda-mb-231 triple negative cell line
granting_institution	Universiti Teknologi Malaysia, Faculty of Science
granting_department	Faculty of Science
publishDate	2020
url	http://eprints.utm.my/id/eprint/102041/1/ZurfarahanimZolkemriMFS2020.pdf
_version_	1776100831915933696

Synergistic cytotoxic effect of thymoquinone in combination with cisplatin against MDA-MB-231 triple negative cell line

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