Octadecylsilane and multiwall carbon nanotubes based cellulose triacetate mixed matrix membrane for new microextraction approaches

Widespread use of pharmaceuticals and herbicides leads to accumulation of their residues in surface water with detrimental effects and they have been recognized as emerging environmental pollutants. Therefore, it is important to develop a suitable sample pre-treatment method for the determination of...

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Main Author:	Ganesan, Thipashini
Format:	Thesis
Language:	English
Published:	2020
Subjects:	QD Chemistry
Online Access:	http://eprints.utm.my/102600/1/ThipashiniGanesanMFS2020.pdf.pdf
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spelling	my-utm-ep.1026002023-09-09T01:50:15Z Octadecylsilane and multiwall carbon nanotubes based cellulose triacetate mixed matrix membrane for new microextraction approaches 2020 Ganesan, Thipashini QD Chemistry Widespread use of pharmaceuticals and herbicides leads to accumulation of their residues in surface water with detrimental effects and they have been recognized as emerging environmental pollutants. Therefore, it is important to develop a suitable sample pre-treatment method for the determination of these compounds in water. In this study, the fabrication of a mixed matrix membrane (MMM) using carbonaceous material immobilized in cellulose triacetate polymer matrix for microextraction is reported. The applicability and reliability of utilizing carbonaceous-based MMM in two different miniaturised microextraction designs, namely dynamic MMM tip extraction and automated flow-through MMM microextraction, are comprehensively demonstrated. To evaluate the performance of dynamic MMM tip extraction, the developed approach was applied for determination of five selected nonsteroidal anti-inflammatory drugs (NSAIDs) namely indoprofen, sulindac, naproxen, diclofenac, and ibuprofen in sewage water samples prior to ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis. The established method showed good linear responses in the concentration range of 0.25–500 pg/mL with correlation coefficients (r) from 0.9988 to 0.9992. The limits of detections (LODs) were 0.08–0.40 pg/mL. The relative recoveries of NSAIDs from spiked water samples were in the range of 92–99% and exhibited excellent precision (relative standard deviations, RSDs ≤ 4.9%). The proposed analytical methodology allowed pre-concentration factors up to 250. Automated flow-through MMM microextraction approach was developed for the analysis of six chlorophenoxy acid herbicides, namely 2-(4-chlorophenoxy)acetic acid, 2-(3,4-dichlorophenoxy)acetic acid, 2-(2,4-dichlorophenoxy)acetic acid, 2-(4-chloro-2-methylphenoxy)acetic acid, 2-(2,4,5-trichlorophenoxy)acetic acid, and 4-(2,4-dichlorophenoxy)butanoic acid in the spiked sewage water sample prior to high performance liquid chromatography-ultraviolet detection (HPLC-UV) analysis. Under optimum conditions, the linearity of this method ranged from 50 - 1000 ng/mL with correlation coefficients (r) ≥ 0.9939, while LODs ranged from 15 - 20 ng/mL. The recoveries of the compounds in spiked sewage water samples were from 95% to 99% with RSDs ≤7.5% and enrichment factors of 19 to 55. The developed analytical methodology has the advantage of requiring less adsorbent (only 62.5 μg) and less organic reagent (60 μL of desorption solvent). 2020 Thesis http://eprints.utm.my/102600/ http://eprints.utm.my/102600/1/ThipashiniGanesanMFS2020.pdf.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:146305 masters Universiti Teknologi Malaysia Faculty of Science
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Ganesan, Thipashini Octadecylsilane and multiwall carbon nanotubes based cellulose triacetate mixed matrix membrane for new microextraction approaches
description	Widespread use of pharmaceuticals and herbicides leads to accumulation of their residues in surface water with detrimental effects and they have been recognized as emerging environmental pollutants. Therefore, it is important to develop a suitable sample pre-treatment method for the determination of these compounds in water. In this study, the fabrication of a mixed matrix membrane (MMM) using carbonaceous material immobilized in cellulose triacetate polymer matrix for microextraction is reported. The applicability and reliability of utilizing carbonaceous-based MMM in two different miniaturised microextraction designs, namely dynamic MMM tip extraction and automated flow-through MMM microextraction, are comprehensively demonstrated. To evaluate the performance of dynamic MMM tip extraction, the developed approach was applied for determination of five selected nonsteroidal anti-inflammatory drugs (NSAIDs) namely indoprofen, sulindac, naproxen, diclofenac, and ibuprofen in sewage water samples prior to ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis. The established method showed good linear responses in the concentration range of 0.25–500 pg/mL with correlation coefficients (r) from 0.9988 to 0.9992. The limits of detections (LODs) were 0.08–0.40 pg/mL. The relative recoveries of NSAIDs from spiked water samples were in the range of 92–99% and exhibited excellent precision (relative standard deviations, RSDs ≤ 4.9%). The proposed analytical methodology allowed pre-concentration factors up to 250. Automated flow-through MMM microextraction approach was developed for the analysis of six chlorophenoxy acid herbicides, namely 2-(4-chlorophenoxy)acetic acid, 2-(3,4-dichlorophenoxy)acetic acid, 2-(2,4-dichlorophenoxy)acetic acid, 2-(4-chloro-2-methylphenoxy)acetic acid, 2-(2,4,5-trichlorophenoxy)acetic acid, and 4-(2,4-dichlorophenoxy)butanoic acid in the spiked sewage water sample prior to high performance liquid chromatography-ultraviolet detection (HPLC-UV) analysis. Under optimum conditions, the linearity of this method ranged from 50 - 1000 ng/mL with correlation coefficients (r) ≥ 0.9939, while LODs ranged from 15 - 20 ng/mL. The recoveries of the compounds in spiked sewage water samples were from 95% to 99% with RSDs ≤7.5% and enrichment factors of 19 to 55. The developed analytical methodology has the advantage of requiring less adsorbent (only 62.5 μg) and less organic reagent (60 μL of desorption solvent).
format	Thesis
qualification_level	Master's degree
author	Ganesan, Thipashini
author_facet	Ganesan, Thipashini
author_sort	Ganesan, Thipashini
title	Octadecylsilane and multiwall carbon nanotubes based cellulose triacetate mixed matrix membrane for new microextraction approaches
title_short	Octadecylsilane and multiwall carbon nanotubes based cellulose triacetate mixed matrix membrane for new microextraction approaches
title_full	Octadecylsilane and multiwall carbon nanotubes based cellulose triacetate mixed matrix membrane for new microextraction approaches
title_fullStr	Octadecylsilane and multiwall carbon nanotubes based cellulose triacetate mixed matrix membrane for new microextraction approaches
title_full_unstemmed	Octadecylsilane and multiwall carbon nanotubes based cellulose triacetate mixed matrix membrane for new microextraction approaches
title_sort	octadecylsilane and multiwall carbon nanotubes based cellulose triacetate mixed matrix membrane for new microextraction approaches
granting_institution	Universiti Teknologi Malaysia
granting_department	Faculty of Science
publishDate	2020
url	http://eprints.utm.my/102600/1/ThipashiniGanesanMFS2020.pdf.pdf
_version_	1783729190490603520

Octadecylsilane and multiwall carbon nanotubes based cellulose triacetate mixed matrix membrane for new microextraction approaches

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