Comparative study of feature selection method of microarray data for gene classification

Recent advances in biotechnology such as microarray, offer the ability to measure the levels of expression of thousands of genes in parallel. Analysis of microarray data can provide understanding and insight into gene function and regulatory mechanisms. This analysis is crucial to identify and class...

全面介紹

Saved in:
書目詳細資料
主要作者: Ghazali, Nurulhuda
格式: Thesis
語言:English
出版: 2009
主題:
在線閱讀:http://eprints.utm.my/id/eprint/11502/6/NurulhudaGhazaliMFSKSM2009.pdf
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!
實物特徵
總結:Recent advances in biotechnology such as microarray, offer the ability to measure the levels of expression of thousands of genes in parallel. Analysis of microarray data can provide understanding and insight into gene function and regulatory mechanisms. This analysis is crucial to identify and classify cancer diseases. Recent technology in cancer classification is based on gene expression profile rather than on morphological appearance of the tumor. However, this task is made more difficult due to the noisy nature of microarray data and the overwhelming number of genes. Thus, it is an important issue to select a small subset of genes to represent thousands of genes in microarray data which is referred as informative genes. These informative genes will then be classified according to its appropriate classes. To achieve the best solution to the classification issue, we proposed an approach of minimum Redundancy-Maximum Relevance feature selection method together with Probabilistic Neural Network classifier. The minimum Redundancy- Maximum Relevance feature selection method is used to select the informative genes while the Probabilistic Neural Network classifier acts as the classifier. This approach has been tested on a well-known cancer dataset which is Leukemia. The results achieved shows that the gene selected had given high classification accuracy. This reduction of genes helps take out some burdens from biologist and better classification accuracy can be used widely to detect cancer in early stage.