Loading capacity and release property of piperine loaded silica aerogel and silica xerogel

The feasibility of silica matrix as an oral drug delivery carrier for natural product was explored. Piperine was loaded into silica aerogel and xerogel via three different methods; impregnation, physical mixing and direct synthesis. Fourier-transform infrared (FTIR) and ultraviolet-visible (UV-Vis)...

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Main Author:	Mohd. Yunos, Nurul Hidayah
Format:	Thesis
Language:	English
Published:	2010
Subjects:	QD Chemistry
Online Access:	http://eprints.utm.my/id/eprint/12332/1/NurulHidayahMohdMFS2010.pdf
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id	my-utm-ep.12332
record_format	uketd_dc
spelling	my-utm-ep.123322017-09-13T03:43:45Z Loading capacity and release property of piperine loaded silica aerogel and silica xerogel 2010 Mohd. Yunos, Nurul Hidayah QD Chemistry The feasibility of silica matrix as an oral drug delivery carrier for natural product was explored. Piperine was loaded into silica aerogel and xerogel via three different methods; impregnation, physical mixing and direct synthesis. Fourier-transform infrared (FTIR) and ultraviolet-visible (UV-Vis) spectroscopies results strongly indicated that no detectable drug degradation had occurred during the loading procedure. Brunauer-Emmett-Teller surface analysis (BET), X-ray diffraction (XRD), and field-emission scanning electron microscopy (FESEM) results indicated the successful loading of piperine into silica matrices. XRD results show the amorphization of piperine crystals after loading process with silica aerogel or xerogel, indicating the increment in the specific surface area of the drug. The degree of crystallinity of piperine loaded silica aerogel is extremely low compared to piperine-xerogel formulations. UV-Vis spectroscopy analysis revealed that the amount of piperine loaded was higher in silica aerogel than silica xerogel. This was due to the larger pore and higher surface area of silica aerogel compared to silica xerogel. Investigation on the release profile of piperine from loaded silica matrices in simulated gastric and intestinal fluids found that piperine loaded silica matrices dissolve faster than crystalline drug due to increase in specific surface area and non crystallinity state of the system. Piperine loaded silica aerogel gave the fastest dissolution (up to 100%), followed by piperine-xerogel (up to 45%) and crystalline piperine (< 5%). Formulations prepared via direct synthesis showed the fastest release, followed by impregnated and physically mixed systems. The ease in collapse of the silica matrices structure in water was observed to favor a faster release. 2010 Thesis http://eprints.utm.my/id/eprint/12332/ http://eprints.utm.my/id/eprint/12332/1/NurulHidayahMohdMFS2010.pdf application/pdf en public masters Universiti Teknologi Malaysia, Faculty of Science Faculty of Science
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Mohd. Yunos, Nurul Hidayah Loading capacity and release property of piperine loaded silica aerogel and silica xerogel
description	The feasibility of silica matrix as an oral drug delivery carrier for natural product was explored. Piperine was loaded into silica aerogel and xerogel via three different methods; impregnation, physical mixing and direct synthesis. Fourier-transform infrared (FTIR) and ultraviolet-visible (UV-Vis) spectroscopies results strongly indicated that no detectable drug degradation had occurred during the loading procedure. Brunauer-Emmett-Teller surface analysis (BET), X-ray diffraction (XRD), and field-emission scanning electron microscopy (FESEM) results indicated the successful loading of piperine into silica matrices. XRD results show the amorphization of piperine crystals after loading process with silica aerogel or xerogel, indicating the increment in the specific surface area of the drug. The degree of crystallinity of piperine loaded silica aerogel is extremely low compared to piperine-xerogel formulations. UV-Vis spectroscopy analysis revealed that the amount of piperine loaded was higher in silica aerogel than silica xerogel. This was due to the larger pore and higher surface area of silica aerogel compared to silica xerogel. Investigation on the release profile of piperine from loaded silica matrices in simulated gastric and intestinal fluids found that piperine loaded silica matrices dissolve faster than crystalline drug due to increase in specific surface area and non crystallinity state of the system. Piperine loaded silica aerogel gave the fastest dissolution (up to 100%), followed by piperine-xerogel (up to 45%) and crystalline piperine (< 5%). Formulations prepared via direct synthesis showed the fastest release, followed by impregnated and physically mixed systems. The ease in collapse of the silica matrices structure in water was observed to favor a faster release.
format	Thesis
qualification_level	Master's degree
author	Mohd. Yunos, Nurul Hidayah
author_facet	Mohd. Yunos, Nurul Hidayah
author_sort	Mohd. Yunos, Nurul Hidayah
title	Loading capacity and release property of piperine loaded silica aerogel and silica xerogel
title_short	Loading capacity and release property of piperine loaded silica aerogel and silica xerogel
title_full	Loading capacity and release property of piperine loaded silica aerogel and silica xerogel
title_fullStr	Loading capacity and release property of piperine loaded silica aerogel and silica xerogel
title_full_unstemmed	Loading capacity and release property of piperine loaded silica aerogel and silica xerogel
title_sort	loading capacity and release property of piperine loaded silica aerogel and silica xerogel
granting_institution	Universiti Teknologi Malaysia, Faculty of Science
granting_department	Faculty of Science
publishDate	2010
url	http://eprints.utm.my/id/eprint/12332/1/NurulHidayahMohdMFS2010.pdf
_version_	1747814925579845632

Loading capacity and release property of piperine loaded silica aerogel and silica xerogel

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