Phytochemicals and bioactivities of Artocarpus Lanceifolius roxb and Artocarpus Maingayi king

Phytochemical studies on Artocarpus lanceifolius Roxb. and Artocarpus maingayi King have successfully isolated seven flavonoids and two plant sterols. Five compounds were successfully isolated from the stem bark of Artocarpus lanceifolius which were identified as 9,19-cyclolanost-24-en-3-acetate, cy...

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Main Author:	Sulaiman, Noor Safina
Format:	Thesis
Language:	English
Published:	2011
Subjects:	QK Botany
Online Access:	http://eprints.utm.my/id/eprint/33396/5/NoorSafinaSulaimanMFS2011.pdf
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spelling	my-utm-ep.333962018-05-27T08:07:38Z Phytochemicals and bioactivities of Artocarpus Lanceifolius roxb and Artocarpus Maingayi king 2011-07 Sulaiman, Noor Safina QK Botany Phytochemical studies on Artocarpus lanceifolius Roxb. and Artocarpus maingayi King have successfully isolated seven flavonoids and two plant sterols. Five compounds were successfully isolated from the stem bark of Artocarpus lanceifolius which were identified as 9,19-cyclolanost-24-en-3-acetate, cycloartobiloxanthone, artonol B, 7,8-(2,2-dimethylchromeno)-10-(2-hydroxyl-1- methylethyl)-2',4',5',5-tetrahydroxyflavone, and artonin E. Two flavans which were tentatively elucidated as 7,8-(2,2-dimethylchromano)-4',4,5-trihydroxy-2'- methoxyflavan and 8-(11-methyl-11-butenyl)-3,4',5,7-tetrahydroxy-2'- methoxyflavan have been isolated from the leaves of Artocarpus lanceifolius. Another two compounds were isolated from the leaves of Artocarpus maingayi which were identified as carpachromene, and ß-sitosterol. Structures of all compounds were elucidated spectroscopically by Nuclear Magnetic Resonance, Infrared, Ultraviolet Spectroscopies and Mass Spectrometry. Biological activities were carried out on the crude extracts and pure compounds. The antimicrobial testing on the crude extracts and pure compounds were carried out against the Gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus and Gram-negative bacteria, Escherichia coli and Pseudomonas aeruginosa. Most of the crude extracts and pure compounds showed significant antimicrobial activity. A pure compound, 7,8-(2, 2- Dimethylchromeno)-10-(2-hydroxyl-1-methylethyl)-2',4',5',5-tetrahydroxyflavone showed most significant antimicrobial activity compared to other isolated compounds and crude extracts with the minimum bactericidal concentration and minimum inhibition concentration value between 31.25 – 62.5 µg/mL. The antioxidant test on the crude extracts and pure compounds from both plant species showed potential free radical scavenger against 2,2-diphenyl-1-picrylhydrazyl. Artonin E exhibited the strongest antioxidant activity with 50% scavenging concentration at 46.9 µg/mL while the ethyl acetate crude extract from the stem bark of Artocarpus maingayi showed 50% scavenging concentration at 60.1 µg/mL. 2011-07 Thesis http://eprints.utm.my/id/eprint/33396/ http://eprints.utm.my/id/eprint/33396/5/NoorSafinaSulaimanMFS2011.pdf application/pdf en public masters Universiti Teknologi Malaysia, Faculty of Science Faculty of Science
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	QK Botany
spellingShingle	QK Botany Sulaiman, Noor Safina Phytochemicals and bioactivities of Artocarpus Lanceifolius roxb and Artocarpus Maingayi king
description	Phytochemical studies on Artocarpus lanceifolius Roxb. and Artocarpus maingayi King have successfully isolated seven flavonoids and two plant sterols. Five compounds were successfully isolated from the stem bark of Artocarpus lanceifolius which were identified as 9,19-cyclolanost-24-en-3-acetate, cycloartobiloxanthone, artonol B, 7,8-(2,2-dimethylchromeno)-10-(2-hydroxyl-1- methylethyl)-2',4',5',5-tetrahydroxyflavone, and artonin E. Two flavans which were tentatively elucidated as 7,8-(2,2-dimethylchromano)-4',4,5-trihydroxy-2'- methoxyflavan and 8-(11-methyl-11-butenyl)-3,4',5,7-tetrahydroxy-2'- methoxyflavan have been isolated from the leaves of Artocarpus lanceifolius. Another two compounds were isolated from the leaves of Artocarpus maingayi which were identified as carpachromene, and ß-sitosterol. Structures of all compounds were elucidated spectroscopically by Nuclear Magnetic Resonance, Infrared, Ultraviolet Spectroscopies and Mass Spectrometry. Biological activities were carried out on the crude extracts and pure compounds. The antimicrobial testing on the crude extracts and pure compounds were carried out against the Gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus and Gram-negative bacteria, Escherichia coli and Pseudomonas aeruginosa. Most of the crude extracts and pure compounds showed significant antimicrobial activity. A pure compound, 7,8-(2, 2- Dimethylchromeno)-10-(2-hydroxyl-1-methylethyl)-2',4',5',5-tetrahydroxyflavone showed most significant antimicrobial activity compared to other isolated compounds and crude extracts with the minimum bactericidal concentration and minimum inhibition concentration value between 31.25 – 62.5 µg/mL. The antioxidant test on the crude extracts and pure compounds from both plant species showed potential free radical scavenger against 2,2-diphenyl-1-picrylhydrazyl. Artonin E exhibited the strongest antioxidant activity with 50% scavenging concentration at 46.9 µg/mL while the ethyl acetate crude extract from the stem bark of Artocarpus maingayi showed 50% scavenging concentration at 60.1 µg/mL.
format	Thesis
qualification_level	Master's degree
author	Sulaiman, Noor Safina
author_facet	Sulaiman, Noor Safina
author_sort	Sulaiman, Noor Safina
title	Phytochemicals and bioactivities of Artocarpus Lanceifolius roxb and Artocarpus Maingayi king
title_short	Phytochemicals and bioactivities of Artocarpus Lanceifolius roxb and Artocarpus Maingayi king
title_full	Phytochemicals and bioactivities of Artocarpus Lanceifolius roxb and Artocarpus Maingayi king
title_fullStr	Phytochemicals and bioactivities of Artocarpus Lanceifolius roxb and Artocarpus Maingayi king
title_full_unstemmed	Phytochemicals and bioactivities of Artocarpus Lanceifolius roxb and Artocarpus Maingayi king
title_sort	phytochemicals and bioactivities of artocarpus lanceifolius roxb and artocarpus maingayi king
granting_institution	Universiti Teknologi Malaysia, Faculty of Science
granting_department	Faculty of Science
publishDate	2011
url	http://eprints.utm.my/id/eprint/33396/5/NoorSafinaSulaimanMFS2011.pdf
_version_	1747816151084171264

Phytochemicals and bioactivities of Artocarpus Lanceifolius roxb and Artocarpus Maingayi king

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