Solid lipid particles for improved dermal delivery of virgin coconut oil

Coconut oil has been recognized as a health oil in Ayurverdic medicine. Virgin Coconut Oil (VCO) is unique because it has a high degree of saturated fats, medium chain triglycerides, antioxidant activity and antimicrobials property. These factors make VCO a suitable lipophilic active ingredient in s...

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Main Author:	Mohamed Noor, Norhayati
Format:	Thesis
Language:	English
Published:	2013
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/34680/5/NorhayatiMohamedNoorMFKK2013.pdf
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spelling	my-utm-ep.346802017-07-23T04:13:00Z Solid lipid particles for improved dermal delivery of virgin coconut oil 2013-03 Mohamed Noor, Norhayati TP Chemical technology Coconut oil has been recognized as a health oil in Ayurverdic medicine. Virgin Coconut Oil (VCO) is unique because it has a high degree of saturated fats, medium chain triglycerides, antioxidant activity and antimicrobials property. These factors make VCO a suitable lipophilic active ingredient in skin care products. VCO is usually extracted from well matured and fresh coconut through specialized process and is prepared in such a way that does not damage its natural structure or nutrition. Solid Lipid Particles (SLPs) is a novel delivery system of lipophilic functional cosmetic active ingredients. In this work, formulation, characterization and efficacy of VCO-SLPs have been studied. VCO-SLPs were prepared using ultrasonification of molten stearic acid and virgin coconut oil in an aqueous solution. From screening experiments, the best formula for VCO-SLPs was 1.78% Tween 80, 0.73% soy lecithin, 10% stearic acid, 5% VCO and 82.5% distilled water. Ultrasonicating was performed at several power intensities and different exposure times. The particle sizes of VCO-SLPs obtained were ranged from 0.608 µm to 44.265 µm. The zeta potentials of all the particles were from -43.2 mV to -47.5 mV showing that the particles obtained have good stability. The cumulative permeation of the VCO-SLPs range from 3.83 µg/cm2 to 3.59 µg/cm2 for VCO-SLPs in the range of 0.608 µm to 39.255 µm. VCO-SLPs with the particle size of 0.608 µm was chosen for subsequent study. Double blind skin evaluation test was conducted to analyze the performance of the VCO-SLPs incorporated moisturizing lotion. Moisturizing lotion incorporated with VCO-SLPs was found to increase skin hydration and skin elasticity by 24.8% and 2.60% respectively from day 0 to day 28. This shows that solid lipid particles has the potential to be utilized as a carrier for improved dermal delivery of VCO. 2013-03 Thesis http://eprints.utm.my/id/eprint/34680/ http://eprints.utm.my/id/eprint/34680/5/NorhayatiMohamedNoorMFKK2013.pdf application/pdf en public masters Universiti Teknologi Malaysia, Universiti Teknologi Malaysia, Faculty of Chemical Engineering Faculty of Chemical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Mohamed Noor, Norhayati Solid lipid particles for improved dermal delivery of virgin coconut oil
description	Coconut oil has been recognized as a health oil in Ayurverdic medicine. Virgin Coconut Oil (VCO) is unique because it has a high degree of saturated fats, medium chain triglycerides, antioxidant activity and antimicrobials property. These factors make VCO a suitable lipophilic active ingredient in skin care products. VCO is usually extracted from well matured and fresh coconut through specialized process and is prepared in such a way that does not damage its natural structure or nutrition. Solid Lipid Particles (SLPs) is a novel delivery system of lipophilic functional cosmetic active ingredients. In this work, formulation, characterization and efficacy of VCO-SLPs have been studied. VCO-SLPs were prepared using ultrasonification of molten stearic acid and virgin coconut oil in an aqueous solution. From screening experiments, the best formula for VCO-SLPs was 1.78% Tween 80, 0.73% soy lecithin, 10% stearic acid, 5% VCO and 82.5% distilled water. Ultrasonicating was performed at several power intensities and different exposure times. The particle sizes of VCO-SLPs obtained were ranged from 0.608 µm to 44.265 µm. The zeta potentials of all the particles were from -43.2 mV to -47.5 mV showing that the particles obtained have good stability. The cumulative permeation of the VCO-SLPs range from 3.83 µg/cm2 to 3.59 µg/cm2 for VCO-SLPs in the range of 0.608 µm to 39.255 µm. VCO-SLPs with the particle size of 0.608 µm was chosen for subsequent study. Double blind skin evaluation test was conducted to analyze the performance of the VCO-SLPs incorporated moisturizing lotion. Moisturizing lotion incorporated with VCO-SLPs was found to increase skin hydration and skin elasticity by 24.8% and 2.60% respectively from day 0 to day 28. This shows that solid lipid particles has the potential to be utilized as a carrier for improved dermal delivery of VCO.
format	Thesis
qualification_level	Master's degree
author	Mohamed Noor, Norhayati
author_facet	Mohamed Noor, Norhayati
author_sort	Mohamed Noor, Norhayati
title	Solid lipid particles for improved dermal delivery of virgin coconut oil
title_short	Solid lipid particles for improved dermal delivery of virgin coconut oil
title_full	Solid lipid particles for improved dermal delivery of virgin coconut oil
title_fullStr	Solid lipid particles for improved dermal delivery of virgin coconut oil
title_full_unstemmed	Solid lipid particles for improved dermal delivery of virgin coconut oil
title_sort	solid lipid particles for improved dermal delivery of virgin coconut oil
granting_institution	Universiti Teknologi Malaysia, Universiti Teknologi Malaysia, Faculty of Chemical Engineering
granting_department	Faculty of Chemical Engineering
publishDate	2013
url	http://eprints.utm.my/id/eprint/34680/5/NorhayatiMohamedNoorMFKK2013.pdf
_version_	1747816233240100864

Solid lipid particles for improved dermal delivery of virgin coconut oil

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