Effect of PEG additives on performance of hemodialysis membrane

Dialysis membranes are fast gaining importance nowadays in membrane separation industries, mainly used in medical industry to remove uremic toxic, excess water and undesirable protein out of the human blood. Unfortunately, the current trend of dialysis technology in Malaysia still depends on foreign...

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Main Author:	Lee, Kuan Yet
Format:	Thesis
Language:	English
Published:	2005
Subjects:	Q Science (General)
Online Access:	http://eprints.utm.my/id/eprint/3483/1/LeeKuanYetMFChe2005.pdf
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id	my-utm-ep.3483
record_format	uketd_dc
spelling	my-utm-ep.34832018-06-25T01:04:38Z Effect of PEG additives on performance of hemodialysis membrane 2005-12 Lee, Kuan Yet Q Science (General) Dialysis membranes are fast gaining importance nowadays in membrane separation industries, mainly used in medical industry to remove uremic toxic, excess water and undesirable protein out of the human blood. Unfortunately, the current trend of dialysis technology in Malaysia still depends on foreign countries and the development of dialysis industries are far behind the world latest era. Therefore, the main objective of this study is to develop flat sheet membranes, suitable for dialysis of biomolecules such as urea and determine the optimum formulation for the dialysis membrane produced. The performance of the cellulose acetate membranes produced using various dope solution formulations were studied by varying the acetic acid (Acc)/polyethylene glycol (PEG) ratio and the amount of water as well as the different molecular weight PEG used. Three different additives were used namely PEG 200, PEG 400 and PEG 600 in the membrane formulations. The membranes were tested using a single layer continuous dialysis system. The molecular weight cut off clearance efficiency range, the permeability and sieving properties of the dialysis membranes were determined. The response surface method, central composite design was applied to construct the experimental trials for this study. Cross section image of each membrane produced were obtained by scanning electron microscopy (SEM) to explain the results obtained. The results revealed that the ratio of acetic acid/PEG is the significant factor that affects urea clearance performance. The amount of the distilled water was an insignificant factor to urea clearance performance, but its presence is vital in the membrane formulation. Dialysis membranes consist of acetic acid/PEG ratio of 16.5 gives the best urea clearance performance of 40.37 %. Among the additives used, PEG 200 shows the highest clearance rate of urea. When a triple layer continuous dialysis system was used to test the membranes and it was found that the performance was increase by 25-50 %. Dialysis membranes consisting of lower molecular additives gives higher molecular clearance cut off efficiency. Final stage experiments using human blood revealed that dialysis membranes produced were comparable to the commercialized membranes with urea clearance of 60-70 % 2005-12 Thesis http://eprints.utm.my/id/eprint/3483/ http://eprints.utm.my/id/eprint/3483/1/LeeKuanYetMFChe2005.pdf application/pdf en public https://www.researchgate.net/publication/48268074_Effect_of_PEG_additives_on_performance_of_hemodialysis_membrane masters Universiti Teknologi Malaysia, Faculty of Chemical and Natural Resources Engineering Faculty of Chemical and Natural Resources Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Lee, Kuan Yet Effect of PEG additives on performance of hemodialysis membrane
description	Dialysis membranes are fast gaining importance nowadays in membrane separation industries, mainly used in medical industry to remove uremic toxic, excess water and undesirable protein out of the human blood. Unfortunately, the current trend of dialysis technology in Malaysia still depends on foreign countries and the development of dialysis industries are far behind the world latest era. Therefore, the main objective of this study is to develop flat sheet membranes, suitable for dialysis of biomolecules such as urea and determine the optimum formulation for the dialysis membrane produced. The performance of the cellulose acetate membranes produced using various dope solution formulations were studied by varying the acetic acid (Acc)/polyethylene glycol (PEG) ratio and the amount of water as well as the different molecular weight PEG used. Three different additives were used namely PEG 200, PEG 400 and PEG 600 in the membrane formulations. The membranes were tested using a single layer continuous dialysis system. The molecular weight cut off clearance efficiency range, the permeability and sieving properties of the dialysis membranes were determined. The response surface method, central composite design was applied to construct the experimental trials for this study. Cross section image of each membrane produced were obtained by scanning electron microscopy (SEM) to explain the results obtained. The results revealed that the ratio of acetic acid/PEG is the significant factor that affects urea clearance performance. The amount of the distilled water was an insignificant factor to urea clearance performance, but its presence is vital in the membrane formulation. Dialysis membranes consist of acetic acid/PEG ratio of 16.5 gives the best urea clearance performance of 40.37 %. Among the additives used, PEG 200 shows the highest clearance rate of urea. When a triple layer continuous dialysis system was used to test the membranes and it was found that the performance was increase by 25-50 %. Dialysis membranes consisting of lower molecular additives gives higher molecular clearance cut off efficiency. Final stage experiments using human blood revealed that dialysis membranes produced were comparable to the commercialized membranes with urea clearance of 60-70 %
format	Thesis
qualification_level	Master's degree
author	Lee, Kuan Yet
author_facet	Lee, Kuan Yet
author_sort	Lee, Kuan Yet
title	Effect of PEG additives on performance of hemodialysis membrane
title_short	Effect of PEG additives on performance of hemodialysis membrane
title_full	Effect of PEG additives on performance of hemodialysis membrane
title_fullStr	Effect of PEG additives on performance of hemodialysis membrane
title_full_unstemmed	Effect of PEG additives on performance of hemodialysis membrane
title_sort	effect of peg additives on performance of hemodialysis membrane
granting_institution	Universiti Teknologi Malaysia, Faculty of Chemical and Natural Resources Engineering
granting_department	Faculty of Chemical and Natural Resources Engineering
publishDate	2005
url	http://eprints.utm.my/id/eprint/3483/1/LeeKuanYetMFChe2005.pdf
_version_	1747814450967085056

Effect of PEG additives on performance of hemodialysis membrane

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