Effect of silver-based products on simulated body fluids

Zeolites A, Y, clinoptilolite, bentonite and kaolinite were applied as a carrier material to attach antibacterial agents of silver ion (Ag+) (Silver based product (Ag-BP)). They were analyzed by EDX and FTIR spectroscopy and showed that the Ag+ attached on the zeolites and clays while the main struc...

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Main Author:	Sanati, Parisa
Format:	Thesis
Language:	English
Published:	2013
Subjects:	RM Therapeutics Pharmacology TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/36768/1/ParisaSanatiMFBSK2013.pdf
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id	my-utm-ep.36768
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spelling	my-utm-ep.367682017-09-17T01:53:38Z Effect of silver-based products on simulated body fluids 2013-01 Sanati, Parisa RM Therapeutics. Pharmacology TP Chemical technology Zeolites A, Y, clinoptilolite, bentonite and kaolinite were applied as a carrier material to attach antibacterial agents of silver ion (Ag+) (Silver based product (Ag-BP)). They were analyzed by EDX and FTIR spectroscopy and showed that the Ag+ attached on the zeolites and clays while the main structure of them did not change significantly. The effects of Ag-BP on simulated body fluid (SBF) and simulated gastric fluid (SGF) were studied in different concentrations. The chemical framework variations of Ag-BP were analyzed by FTIR spectroscopy after contact with SBF and SGF. In FTIR, the most important structural peaks were same as those parents represent Si-O-Si and Si-O-Al bands. The antibacterial activity of Ag-BP was studied by Kirby-Bauer method against Escherichia coli and the inhibitory zones were found in this assay showing that they have antibacterial activity. Ag-BP had more structural variation after contacted in SGF (pH: 1.2) than SBF (pH: 7.4). With increasing concentration of adding Ag-BP to SGF and SBF, more changes were occurred on their structures. Strong acidic condition in SGF created an acidic attack to Si-O-Si and Si-O-Al bands in main frameworks of SBP. Due to this attack, some bonds such as Si-O-Si and Si-O-Al in Ag-BP were changed and caused to release their chemical agents in SGF. Interactions between SBF and Ag-BP were insignificant because the pH of SBF was not changed after addition of SBPs in SBF. In conclusion, certain structural changes were observed in the framework of Ag-BP and SGF when adding together while these changes were not significant for Ag-BP in SBF. 2013-01 Thesis http://eprints.utm.my/id/eprint/36768/ http://eprints.utm.my/id/eprint/36768/1/ParisaSanatiMFBSK2013.pdf application/pdf en public masters Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering Faculty of Biosciences and Medical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	RM Therapeutics Pharmacology TP Chemical technology
spellingShingle	RM Therapeutics Pharmacology TP Chemical technology Sanati, Parisa Effect of silver-based products on simulated body fluids
description	Zeolites A, Y, clinoptilolite, bentonite and kaolinite were applied as a carrier material to attach antibacterial agents of silver ion (Ag+) (Silver based product (Ag-BP)). They were analyzed by EDX and FTIR spectroscopy and showed that the Ag+ attached on the zeolites and clays while the main structure of them did not change significantly. The effects of Ag-BP on simulated body fluid (SBF) and simulated gastric fluid (SGF) were studied in different concentrations. The chemical framework variations of Ag-BP were analyzed by FTIR spectroscopy after contact with SBF and SGF. In FTIR, the most important structural peaks were same as those parents represent Si-O-Si and Si-O-Al bands. The antibacterial activity of Ag-BP was studied by Kirby-Bauer method against Escherichia coli and the inhibitory zones were found in this assay showing that they have antibacterial activity. Ag-BP had more structural variation after contacted in SGF (pH: 1.2) than SBF (pH: 7.4). With increasing concentration of adding Ag-BP to SGF and SBF, more changes were occurred on their structures. Strong acidic condition in SGF created an acidic attack to Si-O-Si and Si-O-Al bands in main frameworks of SBP. Due to this attack, some bonds such as Si-O-Si and Si-O-Al in Ag-BP were changed and caused to release their chemical agents in SGF. Interactions between SBF and Ag-BP were insignificant because the pH of SBF was not changed after addition of SBPs in SBF. In conclusion, certain structural changes were observed in the framework of Ag-BP and SGF when adding together while these changes were not significant for Ag-BP in SBF.
format	Thesis
qualification_level	Master's degree
author	Sanati, Parisa
author_facet	Sanati, Parisa
author_sort	Sanati, Parisa
title	Effect of silver-based products on simulated body fluids
title_short	Effect of silver-based products on simulated body fluids
title_full	Effect of silver-based products on simulated body fluids
title_fullStr	Effect of silver-based products on simulated body fluids
title_full_unstemmed	Effect of silver-based products on simulated body fluids
title_sort	effect of silver-based products on simulated body fluids
granting_institution	Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering
granting_department	Faculty of Biosciences and Medical Engineering
publishDate	2013
url	http://eprints.utm.my/id/eprint/36768/1/ParisaSanatiMFBSK2013.pdf
_version_	1747816456327790592

Effect of silver-based products on simulated body fluids

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