Effect of silver-based products on simulated body fluids
Zeolites A, Y, clinoptilolite, bentonite and kaolinite were applied as a carrier material to attach antibacterial agents of silver ion (Ag+) (Silver based product (Ag-BP)). They were analyzed by EDX and FTIR spectroscopy and showed that the Ag+ attached on the zeolites and clays while the main struc...
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my-utm-ep.367682017-09-17T01:53:38Z Effect of silver-based products on simulated body fluids 2013-01 Sanati, Parisa RM Therapeutics. Pharmacology TP Chemical technology Zeolites A, Y, clinoptilolite, bentonite and kaolinite were applied as a carrier material to attach antibacterial agents of silver ion (Ag+) (Silver based product (Ag-BP)). They were analyzed by EDX and FTIR spectroscopy and showed that the Ag+ attached on the zeolites and clays while the main structure of them did not change significantly. The effects of Ag-BP on simulated body fluid (SBF) and simulated gastric fluid (SGF) were studied in different concentrations. The chemical framework variations of Ag-BP were analyzed by FTIR spectroscopy after contact with SBF and SGF. In FTIR, the most important structural peaks were same as those parents represent Si-O-Si and Si-O-Al bands. The antibacterial activity of Ag-BP was studied by Kirby-Bauer method against Escherichia coli and the inhibitory zones were found in this assay showing that they have antibacterial activity. Ag-BP had more structural variation after contacted in SGF (pH: 1.2) than SBF (pH: 7.4). With increasing concentration of adding Ag-BP to SGF and SBF, more changes were occurred on their structures. Strong acidic condition in SGF created an acidic attack to Si-O-Si and Si-O-Al bands in main frameworks of SBP. Due to this attack, some bonds such as Si-O-Si and Si-O-Al in Ag-BP were changed and caused to release their chemical agents in SGF. Interactions between SBF and Ag-BP were insignificant because the pH of SBF was not changed after addition of SBPs in SBF. In conclusion, certain structural changes were observed in the framework of Ag-BP and SGF when adding together while these changes were not significant for Ag-BP in SBF. 2013-01 Thesis http://eprints.utm.my/id/eprint/36768/ http://eprints.utm.my/id/eprint/36768/1/ParisaSanatiMFBSK2013.pdf application/pdf en public masters Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering Faculty of Biosciences and Medical Engineering |
| institution |
Universiti Teknologi Malaysia |
| collection |
UTM Institutional Repository |
| language |
English |
| topic |
RM Therapeutics Pharmacology TP Chemical technology |
| spellingShingle |
RM Therapeutics Pharmacology TP Chemical technology Sanati, Parisa Effect of silver-based products on simulated body fluids |
| description |
Zeolites A, Y, clinoptilolite, bentonite and kaolinite were applied as a carrier material to attach antibacterial agents of silver ion (Ag+) (Silver based product (Ag-BP)). They were analyzed by EDX and FTIR spectroscopy and showed that the Ag+ attached on the zeolites and clays while the main structure of them did not change significantly. The effects of Ag-BP on simulated body fluid (SBF) and simulated gastric fluid (SGF) were studied in different concentrations. The chemical framework variations of Ag-BP were analyzed by FTIR spectroscopy after contact with SBF and SGF. In FTIR, the most important structural peaks were same as those parents represent Si-O-Si and Si-O-Al bands. The antibacterial activity of Ag-BP was studied by Kirby-Bauer method against Escherichia coli and the inhibitory zones were found in this assay showing that they have antibacterial activity. Ag-BP had more structural variation after contacted in SGF (pH: 1.2) than SBF (pH: 7.4). With increasing concentration of adding Ag-BP to SGF and SBF, more changes were occurred on their structures. Strong acidic condition in SGF created an acidic attack to Si-O-Si and Si-O-Al bands in main frameworks of SBP. Due to this attack, some bonds such as Si-O-Si and Si-O-Al in Ag-BP were changed and caused to release their chemical agents in SGF. Interactions between SBF and Ag-BP were insignificant because the pH of SBF was not changed after addition of SBPs in SBF. In conclusion, certain structural changes were observed in the framework of Ag-BP and SGF when adding together while these changes were not significant for Ag-BP in SBF. |
| format |
Thesis |
| qualification_level |
Master's degree |
| author |
Sanati, Parisa |
| author_facet |
Sanati, Parisa |
| author_sort |
Sanati, Parisa |
| title |
Effect of silver-based products on simulated body fluids |
| title_short |
Effect of silver-based products on simulated body fluids |
| title_full |
Effect of silver-based products on simulated body fluids |
| title_fullStr |
Effect of silver-based products on simulated body fluids |
| title_full_unstemmed |
Effect of silver-based products on simulated body fluids |
| title_sort |
effect of silver-based products on simulated body fluids |
| granting_institution |
Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering |
| granting_department |
Faculty of Biosciences and Medical Engineering |
| publishDate |
2013 |
| url |
http://eprints.utm.my/id/eprint/36768/1/ParisaSanatiMFBSK2013.pdf |
| _version_ |
1747816456327790592 |