Three dimensional integrated software development for air-particle flow simulation through image-based upper human airways

The effort to reconstruct and simulate flow-particle behavior in realistic patientspecific airway system requires multi-software skills. Conventionally, pre-processing, simulation and optimization and post-processing stages are carried out explicitly via a combination of commercial, open source and/...

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Main Author:	Ngali, Mohd Zamani
Format:	Thesis
Language:	English
Published:	2013
Subjects:	TJ Mechanical engineering and machinery
Online Access:	http://eprints.utm.my/id/eprint/37900/5/MohdZamaniNgaliPFKM2013.pdf
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id	my-utm-ep.37900
record_format	uketd_dc
spelling	my-utm-ep.379002017-07-19T07:06:43Z Three dimensional integrated software development for air-particle flow simulation through image-based upper human airways 2013-05 Ngali, Mohd Zamani TJ Mechanical engineering and machinery The effort to reconstruct and simulate flow-particle behavior in realistic patientspecific airway system requires multi-software skills. Conventionally, pre-processing, simulation and optimization and post-processing stages are carried out explicitly via a combination of commercial, open source and/or in-house engineering software. The tedious procedure had left more significant medical analysis such as flow pattern classification, patient group-based flow analysis and statistical flow studies at bay. In this work, the focus is on the development of a dedicated software that is capable of performing all the three stages for any patient-specific data set. A novel approach of combining the efficient Immersed Boundary method and Finite Difference Splitting solver within a matrix-based open source programming platform has radically simplified the procedure especially in the pre-processing stage. The air and particle interactions are based on Eulerian-Lagrangian technique with comprehensive validations for each stage of the solvers integration. A non-dimensional convergence error of less than 1 x 10-6 was consistently set for all the validations. An air flow rate of 30 litre / minute was used throughout the analyses representing the normal inhalation condition while a number of 10,000 and 5,000 micro particles were modeled for simplified and image-based airways respectively. The assessment analysis showed that 42.35% of the particles inhaled by female subject managed to reach the end of trachea while male subject with epiglottis blockage recorded only 0.43%. None of the inhaled particles managed to pass through the trachea of the oversized male subject. This work suggests that such pattern analyses are crucial to facilitate medical practitioners in their patient-specific diagnosis and decision making process of airway flow related diseases. 2013-05 Thesis http://eprints.utm.my/id/eprint/37900/ http://eprints.utm.my/id/eprint/37900/5/MohdZamaniNgaliPFKM2013.pdf application/pdf en public phd doctoral Universiti Teknologi Malaysia, Faculty of Mechanical Engineering Faculty of Mechanical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TJ Mechanical engineering and machinery
spellingShingle	TJ Mechanical engineering and machinery Ngali, Mohd Zamani Three dimensional integrated software development for air-particle flow simulation through image-based upper human airways
description	The effort to reconstruct and simulate flow-particle behavior in realistic patientspecific airway system requires multi-software skills. Conventionally, pre-processing, simulation and optimization and post-processing stages are carried out explicitly via a combination of commercial, open source and/or in-house engineering software. The tedious procedure had left more significant medical analysis such as flow pattern classification, patient group-based flow analysis and statistical flow studies at bay. In this work, the focus is on the development of a dedicated software that is capable of performing all the three stages for any patient-specific data set. A novel approach of combining the efficient Immersed Boundary method and Finite Difference Splitting solver within a matrix-based open source programming platform has radically simplified the procedure especially in the pre-processing stage. The air and particle interactions are based on Eulerian-Lagrangian technique with comprehensive validations for each stage of the solvers integration. A non-dimensional convergence error of less than 1 x 10-6 was consistently set for all the validations. An air flow rate of 30 litre / minute was used throughout the analyses representing the normal inhalation condition while a number of 10,000 and 5,000 micro particles were modeled for simplified and image-based airways respectively. The assessment analysis showed that 42.35% of the particles inhaled by female subject managed to reach the end of trachea while male subject with epiglottis blockage recorded only 0.43%. None of the inhaled particles managed to pass through the trachea of the oversized male subject. This work suggests that such pattern analyses are crucial to facilitate medical practitioners in their patient-specific diagnosis and decision making process of airway flow related diseases.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Ngali, Mohd Zamani
author_facet	Ngali, Mohd Zamani
author_sort	Ngali, Mohd Zamani
title	Three dimensional integrated software development for air-particle flow simulation through image-based upper human airways
title_short	Three dimensional integrated software development for air-particle flow simulation through image-based upper human airways
title_full	Three dimensional integrated software development for air-particle flow simulation through image-based upper human airways
title_fullStr	Three dimensional integrated software development for air-particle flow simulation through image-based upper human airways
title_full_unstemmed	Three dimensional integrated software development for air-particle flow simulation through image-based upper human airways
title_sort	three dimensional integrated software development for air-particle flow simulation through image-based upper human airways
granting_institution	Universiti Teknologi Malaysia, Faculty of Mechanical Engineering
granting_department	Faculty of Mechanical Engineering
publishDate	2013
url	http://eprints.utm.my/id/eprint/37900/5/MohdZamaniNgaliPFKM2013.pdf
_version_	1747816509868081152

Three dimensional integrated software development for air-particle flow simulation through image-based upper human airways

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