Synthesis and characterization of polyacrylamide/sodium carboxymethyl cellulose/montmorillonite nanocomposite hydrogel vaginal ring for drug delivery systems

This research developed a hydrogel vaginal ring consisting of polyacrylamide (AAm), sodium carboxymethylcellulose (NaCMC) for vaginal drug delivery. To improve the swelling behaviour of vaginal ring, different concentrations of NaCMC were utilized. The results indicated that 0.1 g NaCMC had the high...

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Main Author:	Sharifzadeh, Ghorbanali
Format:	Thesis
Language:	English
Published:	2013
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/40595/5/GhorbanaliSharifzadehMFKK2013.pdf
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id	my-utm-ep.40595
record_format	uketd_dc
spelling	my-utm-ep.405952017-07-04T00:36:02Z Synthesis and characterization of polyacrylamide/sodium carboxymethyl cellulose/montmorillonite nanocomposite hydrogel vaginal ring for drug delivery systems 2013-08 Sharifzadeh, Ghorbanali TP Chemical technology This research developed a hydrogel vaginal ring consisting of polyacrylamide (AAm), sodium carboxymethylcellulose (NaCMC) for vaginal drug delivery. To improve the swelling behaviour of vaginal ring, different concentrations of NaCMC were utilized. The results indicated that 0.1 g NaCMC had the highest amount of swelling. However, by increasing the swelling characteristic of vaginal ring, a low strength hydrogel was obtained. Therefore, N,N'-methylenebisacrylamide (MBA) was applied to the hydrogel in order to study the effect of cross-linker on prepared polymer efficiency and swelling properties. By adding of MBA within vaginal ring network, sufficient stability as well as proper swelling properties was obtained. It was found that vaginal ring composed of 0.1 g NaCMC and 0.02 g MBA showed the optimum swelling and suitable structure stability. In addition, montmorillonite (MMT) was added to the blank hydrogel (AAm/NaCMC) to investigate its effect on drug delivery in the simulated vaginal environment (pH= 4- 4.5). Both blank and nanocomposite vaginal rings were loaded with methylene blue (MB) as a modelled drug. The vaginal rings were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscope (SEM), Xray Diffraction (XRD) and Nuclear Magnetic Resonance (NMR). In vitro release behavior of MB illustrated that incorporation of MMT into vaginal ring controlled the drug delivery. It was found that by changing the concentration of MMT from 0.007 g to 0.01 gr, the drug release was prolonged for 15 days by reducing the initial drug release. According to the results, AAm/NaCMC/MMT nanocomposite hydrogel vaginal rings can be considered as good candidates for the vaginal drug delivery 2013-08 Thesis http://eprints.utm.my/id/eprint/40595/ http://eprints.utm.my/id/eprint/40595/5/GhorbanaliSharifzadehMFKK2013.pdf application/pdf en public masters Universiti Teknologi Malaysia, Faculty of Chemical Engineering Faculty of Chemical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Sharifzadeh, Ghorbanali Synthesis and characterization of polyacrylamide/sodium carboxymethyl cellulose/montmorillonite nanocomposite hydrogel vaginal ring for drug delivery systems
description	This research developed a hydrogel vaginal ring consisting of polyacrylamide (AAm), sodium carboxymethylcellulose (NaCMC) for vaginal drug delivery. To improve the swelling behaviour of vaginal ring, different concentrations of NaCMC were utilized. The results indicated that 0.1 g NaCMC had the highest amount of swelling. However, by increasing the swelling characteristic of vaginal ring, a low strength hydrogel was obtained. Therefore, N,N'-methylenebisacrylamide (MBA) was applied to the hydrogel in order to study the effect of cross-linker on prepared polymer efficiency and swelling properties. By adding of MBA within vaginal ring network, sufficient stability as well as proper swelling properties was obtained. It was found that vaginal ring composed of 0.1 g NaCMC and 0.02 g MBA showed the optimum swelling and suitable structure stability. In addition, montmorillonite (MMT) was added to the blank hydrogel (AAm/NaCMC) to investigate its effect on drug delivery in the simulated vaginal environment (pH= 4- 4.5). Both blank and nanocomposite vaginal rings were loaded with methylene blue (MB) as a modelled drug. The vaginal rings were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscope (SEM), Xray Diffraction (XRD) and Nuclear Magnetic Resonance (NMR). In vitro release behavior of MB illustrated that incorporation of MMT into vaginal ring controlled the drug delivery. It was found that by changing the concentration of MMT from 0.007 g to 0.01 gr, the drug release was prolonged for 15 days by reducing the initial drug release. According to the results, AAm/NaCMC/MMT nanocomposite hydrogel vaginal rings can be considered as good candidates for the vaginal drug delivery
format	Thesis
qualification_level	Master's degree
author	Sharifzadeh, Ghorbanali
author_facet	Sharifzadeh, Ghorbanali
author_sort	Sharifzadeh, Ghorbanali
title	Synthesis and characterization of polyacrylamide/sodium carboxymethyl cellulose/montmorillonite nanocomposite hydrogel vaginal ring for drug delivery systems
title_short	Synthesis and characterization of polyacrylamide/sodium carboxymethyl cellulose/montmorillonite nanocomposite hydrogel vaginal ring for drug delivery systems
title_full	Synthesis and characterization of polyacrylamide/sodium carboxymethyl cellulose/montmorillonite nanocomposite hydrogel vaginal ring for drug delivery systems
title_fullStr	Synthesis and characterization of polyacrylamide/sodium carboxymethyl cellulose/montmorillonite nanocomposite hydrogel vaginal ring for drug delivery systems
title_full_unstemmed	Synthesis and characterization of polyacrylamide/sodium carboxymethyl cellulose/montmorillonite nanocomposite hydrogel vaginal ring for drug delivery systems
title_sort	synthesis and characterization of polyacrylamide/sodium carboxymethyl cellulose/montmorillonite nanocomposite hydrogel vaginal ring for drug delivery systems
granting_institution	Universiti Teknologi Malaysia, Faculty of Chemical Engineering
granting_department	Faculty of Chemical Engineering
publishDate	2013
url	http://eprints.utm.my/id/eprint/40595/5/GhorbanaliSharifzadehMFKK2013.pdf
_version_	1747816560113745920

Synthesis and characterization of polyacrylamide/sodium carboxymethyl cellulose/montmorillonite nanocomposite hydrogel vaginal ring for drug delivery systems

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