Protein-protein interactions mapping in the human brain diseases

The human brain acts as the central control of the human nervous system. Environmental factors, human life styles and genetic factors are the main causes of brain diseases. Unfortunately, most of the brain diseases are still incurable because of multiple and complex reasons. Understanding the fundam...

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Main Author: Leong, Geok Wei
Format: Thesis
Published: 2012
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spelling my-utm-ep.419762020-07-14T04:25:52Z Protein-protein interactions mapping in the human brain diseases 2012 Leong, Geok Wei RC Internal medicine The human brain acts as the central control of the human nervous system. Environmental factors, human life styles and genetic factors are the main causes of brain diseases. Unfortunately, most of the brain diseases are still incurable because of multiple and complex reasons. Understanding the fundamental of the disorders is crucial in order to cure or treat them. Protein-protein interactions network study is used to understand the cellular operations in brain cells and there often interconnectivity between different brain diseases. A map of protein-protein interaction network that is associated with brain diseases was created with a total of 844 proteins and 903 interactions using NAViGaTOR and Cytoscape. It was discovered that 17 different brain diseases were interconnected and 61 new proteins were found to be co-expressed with 13 ―interconnector‖ proteins connecting different brain diseases. The results demonstrated that brain diseases are interconnected with each other. The network mapping also revealed the functional and physical interactions which would be very useful for prediction of new protein interactions and protein functions in drug design. It is anticipated that this study would be a reference for a future more sophisticated in vitro research into the protein-protein interactions and future drug design. 2012 Thesis http://eprints.utm.my/id/eprint/41976/ http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:77802?queryType=vitalDismax&query=Protein-protein+interactions+mapping&public=true masters Universiti Teknologi Malaysia, Faculty of Science Faculty of Science
institution Universiti Teknologi Malaysia
collection UTM Institutional Repository
topic RC Internal medicine
spellingShingle RC Internal medicine
Leong, Geok Wei
Protein-protein interactions mapping in the human brain diseases
description The human brain acts as the central control of the human nervous system. Environmental factors, human life styles and genetic factors are the main causes of brain diseases. Unfortunately, most of the brain diseases are still incurable because of multiple and complex reasons. Understanding the fundamental of the disorders is crucial in order to cure or treat them. Protein-protein interactions network study is used to understand the cellular operations in brain cells and there often interconnectivity between different brain diseases. A map of protein-protein interaction network that is associated with brain diseases was created with a total of 844 proteins and 903 interactions using NAViGaTOR and Cytoscape. It was discovered that 17 different brain diseases were interconnected and 61 new proteins were found to be co-expressed with 13 ―interconnector‖ proteins connecting different brain diseases. The results demonstrated that brain diseases are interconnected with each other. The network mapping also revealed the functional and physical interactions which would be very useful for prediction of new protein interactions and protein functions in drug design. It is anticipated that this study would be a reference for a future more sophisticated in vitro research into the protein-protein interactions and future drug design.
format Thesis
qualification_level Master's degree
author Leong, Geok Wei
author_facet Leong, Geok Wei
author_sort Leong, Geok Wei
title Protein-protein interactions mapping in the human brain diseases
title_short Protein-protein interactions mapping in the human brain diseases
title_full Protein-protein interactions mapping in the human brain diseases
title_fullStr Protein-protein interactions mapping in the human brain diseases
title_full_unstemmed Protein-protein interactions mapping in the human brain diseases
title_sort protein-protein interactions mapping in the human brain diseases
granting_institution Universiti Teknologi Malaysia, Faculty of Science
granting_department Faculty of Science
publishDate 2012
_version_ 1747816661857075200