Synthesis and characterization of meso-substituted porphyrin

Porphyrins and their analogs are a class of chemically and biologically important compounds that have found a variety of applications in different fields such as catalysis and medicine, especially for photodynamic cancer therapy (PDT). The physical, chemical, and biological dependence of the periphe...

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Main Author:	Muhammad, Muhammad Tahir
Format:	Thesis
Language:	English
Published:	2014
Subjects:	QD Chemistry
Online Access:	http://eprints.utm.my/id/eprint/50814/25/MuhammadTahirMuhammadMFS2014.pdf
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id	my-utm-ep.50814
record_format	uketd_dc
spelling	my-utm-ep.508142020-07-12T07:05:36Z Synthesis and characterization of meso-substituted porphyrin 2014-06 Muhammad, Muhammad Tahir QD Chemistry Porphyrins and their analogs are a class of chemically and biologically important compounds that have found a variety of applications in different fields such as catalysis and medicine, especially for photodynamic cancer therapy (PDT). The physical, chemical, and biological dependence of the peripheral substituents of porphyrins on their properties has prompted great effort towards the synthesis of new porphyrins with different electronic, steric, and conformational environments. Significant improvement has been made to develop various synthetic methodologies in preparing the functionalised porphyrins. However, the challenges still remain especially to prepare asymmetrical type of porphyrin system which is useful for numerous applications. In this study, we have utilised three synthetic methods; condensation, bromination and Suzuki Cross Coupling reactions to synthesis porphyrins with different meso-substituents; A2-, AB-, A2B-, as well as ABC- type porphyrins. The synthetic strategy is developed based on dipyrromethane as the main precursor to prepare di-substituted porphyrin via Lindsey method, and followed by bromination reaction to obtain tri-substituted porphyrin. Eventually, the reaction was prolonged by using Suzuki- Cross coupling reaction to attain tri-substituted porphyrin. All of the compounds were characterized using Proton Nuclear Magnetic Resonance (1H-NMR), Carbon Magic Angle Spin Nuclear Magnetic Resonance (13C-NMR), ultraviolet (UV) and infrared (IR) spectroscopies. 2014-06 Thesis http://eprints.utm.my/id/eprint/50814/ http://eprints.utm.my/id/eprint/50814/25/MuhammadTahirMuhammadMFS2014.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:89283 masters Universiti Teknologi Malaysia, Faculty of Science Faculty of Science
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Muhammad, Muhammad Tahir Synthesis and characterization of meso-substituted porphyrin
description	Porphyrins and their analogs are a class of chemically and biologically important compounds that have found a variety of applications in different fields such as catalysis and medicine, especially for photodynamic cancer therapy (PDT). The physical, chemical, and biological dependence of the peripheral substituents of porphyrins on their properties has prompted great effort towards the synthesis of new porphyrins with different electronic, steric, and conformational environments. Significant improvement has been made to develop various synthetic methodologies in preparing the functionalised porphyrins. However, the challenges still remain especially to prepare asymmetrical type of porphyrin system which is useful for numerous applications. In this study, we have utilised three synthetic methods; condensation, bromination and Suzuki Cross Coupling reactions to synthesis porphyrins with different meso-substituents; A2-, AB-, A2B-, as well as ABC- type porphyrins. The synthetic strategy is developed based on dipyrromethane as the main precursor to prepare di-substituted porphyrin via Lindsey method, and followed by bromination reaction to obtain tri-substituted porphyrin. Eventually, the reaction was prolonged by using Suzuki- Cross coupling reaction to attain tri-substituted porphyrin. All of the compounds were characterized using Proton Nuclear Magnetic Resonance (1H-NMR), Carbon Magic Angle Spin Nuclear Magnetic Resonance (13C-NMR), ultraviolet (UV) and infrared (IR) spectroscopies.
format	Thesis
qualification_level	Master's degree
author	Muhammad, Muhammad Tahir
author_facet	Muhammad, Muhammad Tahir
author_sort	Muhammad, Muhammad Tahir
title	Synthesis and characterization of meso-substituted porphyrin
title_short	Synthesis and characterization of meso-substituted porphyrin
title_full	Synthesis and characterization of meso-substituted porphyrin
title_fullStr	Synthesis and characterization of meso-substituted porphyrin
title_full_unstemmed	Synthesis and characterization of meso-substituted porphyrin
title_sort	synthesis and characterization of meso-substituted porphyrin
granting_institution	Universiti Teknologi Malaysia, Faculty of Science
granting_department	Faculty of Science
publishDate	2014
url	http://eprints.utm.my/id/eprint/50814/25/MuhammadTahirMuhammadMFS2014.pdf
_version_	1747817540290084864

Synthesis and characterization of meso-substituted porphyrin

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