Characterization and antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite

The current study focused on the preparation, characterization and evaluation for antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite (DUAL-ANTIBAX®). DUAL-ANTIBAX® was prepared by adding Ag-Kaolinite with surfactant, hexadecyltrimethylammonium (HDTMA). The prepared sample...

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Main Author:	Muthoovaloo, Navitra
Format:	Thesis
Language:	English
Published:	2015
Subjects:	R Medicine (General)
Online Access:	http://eprints.utm.my/id/eprint/53832/1/NavitraMuthoovalooMFBME2015.pdf
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id	my-utm-ep.53832
record_format	uketd_dc
spelling	my-utm-ep.538322020-09-07T02:08:01Z Characterization and antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite 2015-07 Muthoovaloo, Navitra R Medicine (General) The current study focused on the preparation, characterization and evaluation for antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite (DUAL-ANTIBAX®). DUAL-ANTIBAX® was prepared by adding Ag-Kaolinite with surfactant, hexadecyltrimethylammonium (HDTMA). The prepared samples; Kao (raw kaolinite), Ag-Kao, HDTMA-Kao and DUAL- ANTIBAX® were characterized using an X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, field emission scanning-electron microscopy (FESEM), energy dispersive X-ray (EDX) analyser, zeta potential analysis and dispersion behaviour. The samples were observed to have no structural changes and HDTMA and Ag were successfully loaded on kaolinite. DUAL-ANTIBAX® has a positive value of zeta potential due to the presence of surfactants. The antibacterial activity of these samples was determined by Minimum Inhibition Concentration (MIC) assay against Staphylococcus aureus and Escherichia coli in different saline solution concentrations (0%, 0.01%, 0.1%, 1.0% and 5.0%) and at different time of incubation (30 minutes and 24 hours). As a result, DUAL-ANTIBAX® showed better antibacterial activity at lower concentration of saline solution. Meanwhile, DUAL-ANTIBAX® exhibited better antibacterial activity at time of incubation of 24 hours compared to 30 minutes. This study also revealed that, DUAL-ANTIBAX® was more effective on the Gram positive bacteria compared to the Gram negative bacteria. As a conclusion, DUAL-ANTIBAX® can be used as an effective antibacterial agent due to the combination of Ag and HDTMA on kaolinite as a carrier system. Results from this study has highlighted the potential use of DUAL-ANTIBAX® as antibacterial agent and may have an implications to the development of new antibacterial agent. 2015-07 Thesis http://eprints.utm.my/id/eprint/53832/ http://eprints.utm.my/id/eprint/53832/1/NavitraMuthoovalooMFBME2015.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:86049 masters Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering Faculty of Biosciences and Medical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Muthoovaloo, Navitra Characterization and antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite
description	The current study focused on the preparation, characterization and evaluation for antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite (DUAL-ANTIBAX®). DUAL-ANTIBAX® was prepared by adding Ag-Kaolinite with surfactant, hexadecyltrimethylammonium (HDTMA). The prepared samples; Kao (raw kaolinite), Ag-Kao, HDTMA-Kao and DUAL- ANTIBAX® were characterized using an X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, field emission scanning-electron microscopy (FESEM), energy dispersive X-ray (EDX) analyser, zeta potential analysis and dispersion behaviour. The samples were observed to have no structural changes and HDTMA and Ag were successfully loaded on kaolinite. DUAL-ANTIBAX® has a positive value of zeta potential due to the presence of surfactants. The antibacterial activity of these samples was determined by Minimum Inhibition Concentration (MIC) assay against Staphylococcus aureus and Escherichia coli in different saline solution concentrations (0%, 0.01%, 0.1%, 1.0% and 5.0%) and at different time of incubation (30 minutes and 24 hours). As a result, DUAL-ANTIBAX® showed better antibacterial activity at lower concentration of saline solution. Meanwhile, DUAL-ANTIBAX® exhibited better antibacterial activity at time of incubation of 24 hours compared to 30 minutes. This study also revealed that, DUAL-ANTIBAX® was more effective on the Gram positive bacteria compared to the Gram negative bacteria. As a conclusion, DUAL-ANTIBAX® can be used as an effective antibacterial agent due to the combination of Ag and HDTMA on kaolinite as a carrier system. Results from this study has highlighted the potential use of DUAL-ANTIBAX® as antibacterial agent and may have an implications to the development of new antibacterial agent.
format	Thesis
qualification_level	Master's degree
author	Muthoovaloo, Navitra
author_facet	Muthoovaloo, Navitra
author_sort	Muthoovaloo, Navitra
title	Characterization and antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite
title_short	Characterization and antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite
title_full	Characterization and antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite
title_fullStr	Characterization and antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite
title_full_unstemmed	Characterization and antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite
title_sort	characterization and antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite
granting_institution	Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering
granting_department	Faculty of Biosciences and Medical Engineering
publishDate	2015
url	http://eprints.utm.my/id/eprint/53832/1/NavitraMuthoovalooMFBME2015.pdf
_version_	1747817637560188928

Characterization and antibacterial activity of hexadecyltrimethylammonium modified silver kaolinite

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