The efficiency of niosome in entrapment of Andrographis paniculata extract

A. Paniculata or also called bile of heart is herb always used in traditional Malaysian medicine for treatment of a wide range of diseases such as diabetes, diarrhea and snake bites. The main bioactive compound which is andrographolide act as an antioxidant, protecting the liver and digestive system...

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Main Author:	Raja Sulong, Raja Safazliana
Format:	Thesis
Language:	English
Published:	2016
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/77873/1/RajaSafazlianaRajaMFChE2016.pdf
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spelling	my-utm-ep.778732018-07-18T04:11:00Z The efficiency of niosome in entrapment of Andrographis paniculata extract 2016-02 Raja Sulong, Raja Safazliana TP Chemical technology A. Paniculata or also called bile of heart is herb always used in traditional Malaysian medicine for treatment of a wide range of diseases such as diabetes, diarrhea and snake bites. The main bioactive compound which is andrographolide act as an antioxidant, protecting the liver and digestive system, antimicrobial and others. This research is to study the efficiency of niosome in entrapment of bioactive compound (andrographolide). The aerial part of plant were taken and extracted in the solvent. The solvent used are ethanol and distilled water. Six of niosomal formulation for the delivery of andrographolide will be developing to achieve effectiveness in entrapment of andropholide. The primary metabolites of A. Paniculata were found and the result shows the water extract have the higher total protein (901.875 mg/mL ± 0.0021) and ethanol extract have the higher glycosaponin in extract (40% ± 0.0021). Zeta potential were in the range of -30mV to -40mV while particle size in the range of 90nm to 200nm. Zeta potential and particle size of niosome indicated all the formulation were stable. Drug entrapment efficiency in the niosomes will be determined spectrophotometrically. Formulation with ethanol solvent extract and surfactant: cholesterol ratio in 0.50: 0.50; F5 indicated the best formulation and give the optimum entrapment of A. Paniculata extract (7.431ppm of andrographolide). The result delivered that this niosomal formulation is determined greatly helpful to improve the encapsulation efficiency of drugs and reduce the release rate of the drug. This study provides a new insight into designing effective niosomal system. 2016-02 Thesis http://eprints.utm.my/id/eprint/77873/ http://eprints.utm.my/id/eprint/77873/1/RajaSafazlianaRajaMFChE2016.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:93958 masters Universiti Teknologi Malaysia, Faculty of Chemical and Energy Engineering Faculty of Chemical and Energy Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Raja Sulong, Raja Safazliana The efficiency of niosome in entrapment of Andrographis paniculata extract
description	A. Paniculata or also called bile of heart is herb always used in traditional Malaysian medicine for treatment of a wide range of diseases such as diabetes, diarrhea and snake bites. The main bioactive compound which is andrographolide act as an antioxidant, protecting the liver and digestive system, antimicrobial and others. This research is to study the efficiency of niosome in entrapment of bioactive compound (andrographolide). The aerial part of plant were taken and extracted in the solvent. The solvent used are ethanol and distilled water. Six of niosomal formulation for the delivery of andrographolide will be developing to achieve effectiveness in entrapment of andropholide. The primary metabolites of A. Paniculata were found and the result shows the water extract have the higher total protein (901.875 mg/mL ± 0.0021) and ethanol extract have the higher glycosaponin in extract (40% ± 0.0021). Zeta potential were in the range of -30mV to -40mV while particle size in the range of 90nm to 200nm. Zeta potential and particle size of niosome indicated all the formulation were stable. Drug entrapment efficiency in the niosomes will be determined spectrophotometrically. Formulation with ethanol solvent extract and surfactant: cholesterol ratio in 0.50: 0.50; F5 indicated the best formulation and give the optimum entrapment of A. Paniculata extract (7.431ppm of andrographolide). The result delivered that this niosomal formulation is determined greatly helpful to improve the encapsulation efficiency of drugs and reduce the release rate of the drug. This study provides a new insight into designing effective niosomal system.
format	Thesis
qualification_level	Master's degree
author	Raja Sulong, Raja Safazliana
author_facet	Raja Sulong, Raja Safazliana
author_sort	Raja Sulong, Raja Safazliana
title	The efficiency of niosome in entrapment of Andrographis paniculata extract
title_short	The efficiency of niosome in entrapment of Andrographis paniculata extract
title_full	The efficiency of niosome in entrapment of Andrographis paniculata extract
title_fullStr	The efficiency of niosome in entrapment of Andrographis paniculata extract
title_full_unstemmed	The efficiency of niosome in entrapment of Andrographis paniculata extract
title_sort	efficiency of niosome in entrapment of andrographis paniculata extract
granting_institution	Universiti Teknologi Malaysia, Faculty of Chemical and Energy Engineering
granting_department	Faculty of Chemical and Energy Engineering
publishDate	2016
url	http://eprints.utm.my/id/eprint/77873/1/RajaSafazlianaRajaMFChE2016.pdf
_version_	1747817851960426496

The efficiency of niosome in entrapment of Andrographis paniculata extract

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