Massive training artificial immune recognition system for lung nodules detection

In the early detection and diagnosis of lung nodule, computer aided detection (CAD) has become crucial to assist radiologists in interpreting medical images and decision making. However, some limitations have been found in the existing CAD algorithms for detecting lung nodules, such as imprecision c...

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Main Author:	Hang, See Pheng
Format:	Thesis
Language:	English
Published:	2014
Subjects:	QA75 Electronic computers Computer science
Online Access:	http://eprints.utm.my/id/eprint/78067/1/HangSeePhengPFC2014.pdf
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spelling	my-utm-ep.780672018-07-23T06:05:54Z Massive training artificial immune recognition system for lung nodules detection 2014-10 Hang, See Pheng QA75 Electronic computers. Computer science In the early detection and diagnosis of lung nodule, computer aided detection (CAD) has become crucial to assist radiologists in interpreting medical images and decision making. However, some limitations have been found in the existing CAD algorithms for detecting lung nodules, such as imprecision classification due to inaccurate segmentation and lengthy computation time. In this research, Massive Training Artificial Immune Recognition System (MTAIRS) is proposed to detect lung nodules on Computed Tomography (CT) scans. MTAIRS is developed based on the pixel machine learning and artificial immune-based system-Artificial Immune Recognition System (AIRS). Two versions of proposed algorithms have been investigated in the study: MTAIRS 1 and MTAIRS 2. Since segmentation and feature calculation are not implemented in the pixel-based machine learning, the loss of information can be avoided during the data training in MTAIRS 1 and MTAIRS 2. The experiment and analysis find that MTAIRS 1 and MTAIRS 2 have successfully reduced the computation time and accomplished good accuracy in the detection of lung nodules on CT scans compared to other well-known pixel-based classification algorithms. Furthermore, MTAIRS 1 and MTAIRS 2 are investigated to improve their performance in eliminating the false positives. A weighted non-linear affinity function is employed in the training of MTAIRS 1 and MTAIRS 2 to replace Euclidean distance in affinity measurement. The enhanced algorithms named, E-MTAIRS 1 and E-MTAIRS 2 are capable to reduce the false positives in the non-nodule classification while maintaining the accuracy in nodule detection. In order to further provide comparative analysis of pixel-based classification algorithms in lung nodules detection, a pixel-based evaluation method of Kullback Leibler (KL) divergence is proposed in this study. Based on the pixel-based quantitative analysis, MTAIRS 1 performs better in the elimination of false positives, while MTAIRS 2 in lung nodules detection. The average detection accuracy for both MTAIRS algorithms is 95%. 2014-10 Thesis http://eprints.utm.my/id/eprint/78067/ http://eprints.utm.my/id/eprint/78067/1/HangSeePhengPFC2014.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:98600 phd doctoral Universiti Teknologi Malaysia, Faculty of Computing Faculty of Computing
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	QA75 Electronic computers Computer science
spellingShingle	QA75 Electronic computers Computer science Hang, See Pheng Massive training artificial immune recognition system for lung nodules detection
description	In the early detection and diagnosis of lung nodule, computer aided detection (CAD) has become crucial to assist radiologists in interpreting medical images and decision making. However, some limitations have been found in the existing CAD algorithms for detecting lung nodules, such as imprecision classification due to inaccurate segmentation and lengthy computation time. In this research, Massive Training Artificial Immune Recognition System (MTAIRS) is proposed to detect lung nodules on Computed Tomography (CT) scans. MTAIRS is developed based on the pixel machine learning and artificial immune-based system-Artificial Immune Recognition System (AIRS). Two versions of proposed algorithms have been investigated in the study: MTAIRS 1 and MTAIRS 2. Since segmentation and feature calculation are not implemented in the pixel-based machine learning, the loss of information can be avoided during the data training in MTAIRS 1 and MTAIRS 2. The experiment and analysis find that MTAIRS 1 and MTAIRS 2 have successfully reduced the computation time and accomplished good accuracy in the detection of lung nodules on CT scans compared to other well-known pixel-based classification algorithms. Furthermore, MTAIRS 1 and MTAIRS 2 are investigated to improve their performance in eliminating the false positives. A weighted non-linear affinity function is employed in the training of MTAIRS 1 and MTAIRS 2 to replace Euclidean distance in affinity measurement. The enhanced algorithms named, E-MTAIRS 1 and E-MTAIRS 2 are capable to reduce the false positives in the non-nodule classification while maintaining the accuracy in nodule detection. In order to further provide comparative analysis of pixel-based classification algorithms in lung nodules detection, a pixel-based evaluation method of Kullback Leibler (KL) divergence is proposed in this study. Based on the pixel-based quantitative analysis, MTAIRS 1 performs better in the elimination of false positives, while MTAIRS 2 in lung nodules detection. The average detection accuracy for both MTAIRS algorithms is 95%.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Hang, See Pheng
author_facet	Hang, See Pheng
author_sort	Hang, See Pheng
title	Massive training artificial immune recognition system for lung nodules detection
title_short	Massive training artificial immune recognition system for lung nodules detection
title_full	Massive training artificial immune recognition system for lung nodules detection
title_fullStr	Massive training artificial immune recognition system for lung nodules detection
title_full_unstemmed	Massive training artificial immune recognition system for lung nodules detection
title_sort	massive training artificial immune recognition system for lung nodules detection
granting_institution	Universiti Teknologi Malaysia, Faculty of Computing
granting_department	Faculty of Computing
publishDate	2014
url	http://eprints.utm.my/id/eprint/78067/1/HangSeePhengPFC2014.pdf
_version_	1747817898919854080

Massive training artificial immune recognition system for lung nodules detection

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