Investigating the blood compatibility of metallocene polyethylene subjected to steam treatment

In this study, one of the green surface modification techniques, steam treatment was employed to improve the surface characteristics and haemocompatibility of metallocene polyethylene (mPE). The mean contact angle of untreated mPE (87.4º) decreased sharply for steam exposed mPE (60.25º). The increas...

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Main Author:	John, Agnes Aruna
Format:	Thesis
Language:	English
Published:	2016
Subjects:	QH301 Biology
Online Access:	http://eprints.utm.my/id/eprint/78443/1/AgnesArunaJohnMFBME2016.pdf
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spelling	my-utm-ep.784432018-08-26T11:55:01Z Investigating the blood compatibility of metallocene polyethylene subjected to steam treatment 2016-01 John, Agnes Aruna QH301 Biology In this study, one of the green surface modification techniques, steam treatment was employed to improve the surface characteristics and haemocompatibility of metallocene polyethylene (mPE). The mean contact angle of untreated mPE (87.4º) decreased sharply for steam exposed mPE (60.25º). The increased surface roughness was demonstrated by atomic force microscopy (AFM), scanning electron microscopy (SEM) and Hirox 3-D microscopy. The mean roughness (Ra) of control mPE (2.757 nm) was increased to 8.753 nm by steam treatment, showed enhanced hydrophilicity. Fourier transform infrared spectroscopy (FTIR) analysis illustrated no chemical changes but the changes in absorbance intensity ensures the morphological changes in the treated samples. The blood compatibility studies were assessed by coagulation assays, haemolysis and platelet adhesion tests. The coagulation assays indicated a delay in clotting time on the steam exposed surface whereas haemolysis and platelet adhesion were significantly reduced. The green surface modification of mPE using steam enhanced its surface properties and haemocompatibility. The improved blood compatibility of mPE may help in efficient designing of haemocompatible biomaterials like cardiovascular implants. 2016-01 Thesis http://eprints.utm.my/id/eprint/78443/ http://eprints.utm.my/id/eprint/78443/1/AgnesArunaJohnMFBME2016.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:110564 masters Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering Faculty of Biosciences and Medical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	QH301 Biology
spellingShingle	QH301 Biology John, Agnes Aruna Investigating the blood compatibility of metallocene polyethylene subjected to steam treatment
description	In this study, one of the green surface modification techniques, steam treatment was employed to improve the surface characteristics and haemocompatibility of metallocene polyethylene (mPE). The mean contact angle of untreated mPE (87.4º) decreased sharply for steam exposed mPE (60.25º). The increased surface roughness was demonstrated by atomic force microscopy (AFM), scanning electron microscopy (SEM) and Hirox 3-D microscopy. The mean roughness (Ra) of control mPE (2.757 nm) was increased to 8.753 nm by steam treatment, showed enhanced hydrophilicity. Fourier transform infrared spectroscopy (FTIR) analysis illustrated no chemical changes but the changes in absorbance intensity ensures the morphological changes in the treated samples. The blood compatibility studies were assessed by coagulation assays, haemolysis and platelet adhesion tests. The coagulation assays indicated a delay in clotting time on the steam exposed surface whereas haemolysis and platelet adhesion were significantly reduced. The green surface modification of mPE using steam enhanced its surface properties and haemocompatibility. The improved blood compatibility of mPE may help in efficient designing of haemocompatible biomaterials like cardiovascular implants.
format	Thesis
qualification_level	Master's degree
author	John, Agnes Aruna
author_facet	John, Agnes Aruna
author_sort	John, Agnes Aruna
title	Investigating the blood compatibility of metallocene polyethylene subjected to steam treatment
title_short	Investigating the blood compatibility of metallocene polyethylene subjected to steam treatment
title_full	Investigating the blood compatibility of metallocene polyethylene subjected to steam treatment
title_fullStr	Investigating the blood compatibility of metallocene polyethylene subjected to steam treatment
title_full_unstemmed	Investigating the blood compatibility of metallocene polyethylene subjected to steam treatment
title_sort	investigating the blood compatibility of metallocene polyethylene subjected to steam treatment
granting_institution	Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering
granting_department	Faculty of Biosciences and Medical Engineering
publishDate	2016
url	http://eprints.utm.my/id/eprint/78443/1/AgnesArunaJohnMFBME2016.pdf
_version_	1747817990049497088

Investigating the blood compatibility of metallocene polyethylene subjected to steam treatment

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