Physico-chemical properties of stainless steel 316L coated with ginseng-poly (lactic-co-glycolic acid) for stent application

Drug eluting stent is a stent coated with an anti-proliferative drug to prevent in-stent restenosis in blood vessels. Although this stent is superior to the bare stent, another post-stenting complication called late thrombosis, occurs as a result of late re-endotheliazation. Therefore, this project...

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Main Author:	Miswan, Zulaika
Format:	Thesis
Language:	English
Published:	2016
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/79095/1/ZulaikaMiswanMFBME2016.pdf
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spelling	my-utm-ep.790952018-09-27T06:07:37Z Physico-chemical properties of stainless steel 316L coated with ginseng-poly (lactic-co-glycolic acid) for stent application 2016-12 Miswan, Zulaika TP Chemical technology Drug eluting stent is a stent coated with an anti-proliferative drug to prevent in-stent restenosis in blood vessels. Although this stent is superior to the bare stent, another post-stenting complication called late thrombosis, occurs as a result of late re-endotheliazation. Therefore, this project was aimed to develop a drug eluting coating with ginseng extract that contained active ingredients of ginsenosides Rg1 and Re, proven to not only inhibit the proliferation of vascular smooth muscle cells but also to promote the growth of vascular endothelial cells. In this project, poly (lactic-co-glycolic) acid (PLGA) matrix was incorporated with ginseng extract at different ratios: 10%, 30% and 50% (w/w). The gelation solvents were then coated on a stainless steel 316L, a substrate, by a dip coating technique. The coatings were characterized by attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM) and contact angle analyses while the drug release profile was studied through one month immersion tests and analyzed by a mass spectrometry instrument (Q-TOF LC-MS). The FTIR analyses confirmed that the coatings were composed of ginseng and PLGA. The SEM images showed that a full coverage and even coating was found on the 30% sample. Higher ratio of PLGA caused higher hydrophobicity but not as high as the bare substrate. The immersion study showed that all PLGA concentrations undergoes initial burst release dependent on the concentrations. The release mechanism for the 30% and 50% samples was a combination of diffusion and swelling-controlled of PLGA whereas the release mechanism for the 10% sample was a Fickian diffusion. The optimum coating was found on the 30% sample as it demonstrated acceptable wettability, even coating coverage and controlled release through the PLGA swelling. The ginseng- PLGA coating by a dip coating technique is practicable and it can be used as a drug eluting coating for stent application. 2016-12 Thesis http://eprints.utm.my/id/eprint/79095/ http://eprints.utm.my/id/eprint/79095/1/ZulaikaMiswanMFBME2016.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:110515 masters Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering Faculty of Biosciences and Medical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Miswan, Zulaika Physico-chemical properties of stainless steel 316L coated with ginseng-poly (lactic-co-glycolic acid) for stent application
description	Drug eluting stent is a stent coated with an anti-proliferative drug to prevent in-stent restenosis in blood vessels. Although this stent is superior to the bare stent, another post-stenting complication called late thrombosis, occurs as a result of late re-endotheliazation. Therefore, this project was aimed to develop a drug eluting coating with ginseng extract that contained active ingredients of ginsenosides Rg1 and Re, proven to not only inhibit the proliferation of vascular smooth muscle cells but also to promote the growth of vascular endothelial cells. In this project, poly (lactic-co-glycolic) acid (PLGA) matrix was incorporated with ginseng extract at different ratios: 10%, 30% and 50% (w/w). The gelation solvents were then coated on a stainless steel 316L, a substrate, by a dip coating technique. The coatings were characterized by attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM) and contact angle analyses while the drug release profile was studied through one month immersion tests and analyzed by a mass spectrometry instrument (Q-TOF LC-MS). The FTIR analyses confirmed that the coatings were composed of ginseng and PLGA. The SEM images showed that a full coverage and even coating was found on the 30% sample. Higher ratio of PLGA caused higher hydrophobicity but not as high as the bare substrate. The immersion study showed that all PLGA concentrations undergoes initial burst release dependent on the concentrations. The release mechanism for the 30% and 50% samples was a combination of diffusion and swelling-controlled of PLGA whereas the release mechanism for the 10% sample was a Fickian diffusion. The optimum coating was found on the 30% sample as it demonstrated acceptable wettability, even coating coverage and controlled release through the PLGA swelling. The ginseng- PLGA coating by a dip coating technique is practicable and it can be used as a drug eluting coating for stent application.
format	Thesis
qualification_level	Master's degree
author	Miswan, Zulaika
author_facet	Miswan, Zulaika
author_sort	Miswan, Zulaika
title	Physico-chemical properties of stainless steel 316L coated with ginseng-poly (lactic-co-glycolic acid) for stent application
title_short	Physico-chemical properties of stainless steel 316L coated with ginseng-poly (lactic-co-glycolic acid) for stent application
title_full	Physico-chemical properties of stainless steel 316L coated with ginseng-poly (lactic-co-glycolic acid) for stent application
title_fullStr	Physico-chemical properties of stainless steel 316L coated with ginseng-poly (lactic-co-glycolic acid) for stent application
title_full_unstemmed	Physico-chemical properties of stainless steel 316L coated with ginseng-poly (lactic-co-glycolic acid) for stent application
title_sort	physico-chemical properties of stainless steel 316l coated with ginseng-poly (lactic-co-glycolic acid) for stent application
granting_institution	Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering
granting_department	Faculty of Biosciences and Medical Engineering
publishDate	2016
url	http://eprints.utm.my/id/eprint/79095/1/ZulaikaMiswanMFBME2016.pdf
_version_	1747818145565900800

Physico-chemical properties of stainless steel 316L coated with ginseng-poly (lactic-co-glycolic acid) for stent application

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