Modified acrylamide hydrogel nanocomposites for varginal drug delivery system

This study conducted on the structure of modified acrylamide-based hydrogel by synthesizing the nano composites. The hydrogels employed in this study were provided through a combination of acrylamide monomers, montmorillonite clay, Sodium carboxymethylcellulose (NaCMC) and magnesium oxide (MgO) nano...

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Main Author:	Mojaveryazdi, Farzaneh Sabbagh
Format:	Thesis
Language:	English
Published:	2017
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/79292/1/FarzanehSabbaghMojaveryazdiPFChE2017.pdf
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spelling	my-utm-ep.792922018-10-14T08:42:04Z Modified acrylamide hydrogel nanocomposites for varginal drug delivery system 2017 Mojaveryazdi, Farzaneh Sabbagh TP Chemical technology This study conducted on the structure of modified acrylamide-based hydrogel by synthesizing the nano composites. The hydrogels employed in this study were provided through a combination of acrylamide monomers, montmorillonite clay, Sodium carboxymethylcellulose (NaCMC) and magnesium oxide (MgO) nanoparticles by crosslinking polymerization. N, N, N’, N’-tetramethyl ethylenediamine and ammonium persulfate as the initiator were applied in the structure of the polymer. In addition, the total of the polymerization and characterization were utilized based on three types of hydrogels which are acrylamide (Aam), Aam/NaCMC and Aam/NaCMC/MgO hydrogels. The properties of surface morphology of the hydrogels were characterized by swelling ratio, field emission scanning electron microscope (FESEM), texture analysis, x-ray diffraction and Fourier transform infrared spectroscopy (FTIR). Findings of the study considered the nano composites consisting of MgO have the highest swelling ratio and gel strength compared to Aam and Aam/NaCMC hydrogels. Thus, MgO is an appropriate nanoparticle to be used in the nano composites. The role of NaCMC was also studied in the swelling and consequently in drug release. The systems were characterized regarding rheological behavior of hydrogel, FTIR, and FESEM. The dispersion of the nanoparticles MgO and drug (acyclovir) inside the hydrogel was shown by transmission electron microscopy. Acyclovir, one of the famous drugs to treat the vaginal infections, was used as the drug for delivery and release in the vagina conditions. It was loaded into the polymer through the soaking method in an aqueous solution contained acyclovir. The drug release was studied in two different mediums, phosphate-buffer saline (PBS) (pH 7.4) and vaginal fluid simulant (SVF) (pH 4.5) aqueous solutions were utilized. The amount of released drug from the hydrogels was determined using high performance liquid chromatography. The best amount of NaCMC and MgO used in this study was 0.2 g and 0.01 g at pH 6, respectively. The aggregate percentage of released acyclovir diversed between 89.7% and 35.1% in SVF and 76.41% and 22.24% in PBS. In this study, the 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay test showed that the acrylamide-based hydrogel demonstrated a cytotoxicity effect at 12.5, 25,50, 100 and 200 mg/ml concentrations. 2017 Thesis http://eprints.utm.my/id/eprint/79292/ http://eprints.utm.my/id/eprint/79292/1/FarzanehSabbaghMojaveryazdiPFChE2017.pdf application/pdf en public phd doctoral Universiti Teknologi Malaysia, Faculty of Chemical & Energy Engineering Faculty of Chemical & Energy Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Mojaveryazdi, Farzaneh Sabbagh Modified acrylamide hydrogel nanocomposites for varginal drug delivery system
description	This study conducted on the structure of modified acrylamide-based hydrogel by synthesizing the nano composites. The hydrogels employed in this study were provided through a combination of acrylamide monomers, montmorillonite clay, Sodium carboxymethylcellulose (NaCMC) and magnesium oxide (MgO) nanoparticles by crosslinking polymerization. N, N, N’, N’-tetramethyl ethylenediamine and ammonium persulfate as the initiator were applied in the structure of the polymer. In addition, the total of the polymerization and characterization were utilized based on three types of hydrogels which are acrylamide (Aam), Aam/NaCMC and Aam/NaCMC/MgO hydrogels. The properties of surface morphology of the hydrogels were characterized by swelling ratio, field emission scanning electron microscope (FESEM), texture analysis, x-ray diffraction and Fourier transform infrared spectroscopy (FTIR). Findings of the study considered the nano composites consisting of MgO have the highest swelling ratio and gel strength compared to Aam and Aam/NaCMC hydrogels. Thus, MgO is an appropriate nanoparticle to be used in the nano composites. The role of NaCMC was also studied in the swelling and consequently in drug release. The systems were characterized regarding rheological behavior of hydrogel, FTIR, and FESEM. The dispersion of the nanoparticles MgO and drug (acyclovir) inside the hydrogel was shown by transmission electron microscopy. Acyclovir, one of the famous drugs to treat the vaginal infections, was used as the drug for delivery and release in the vagina conditions. It was loaded into the polymer through the soaking method in an aqueous solution contained acyclovir. The drug release was studied in two different mediums, phosphate-buffer saline (PBS) (pH 7.4) and vaginal fluid simulant (SVF) (pH 4.5) aqueous solutions were utilized. The amount of released drug from the hydrogels was determined using high performance liquid chromatography. The best amount of NaCMC and MgO used in this study was 0.2 g and 0.01 g at pH 6, respectively. The aggregate percentage of released acyclovir diversed between 89.7% and 35.1% in SVF and 76.41% and 22.24% in PBS. In this study, the 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay test showed that the acrylamide-based hydrogel demonstrated a cytotoxicity effect at 12.5, 25,50, 100 and 200 mg/ml concentrations.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Mojaveryazdi, Farzaneh Sabbagh
author_facet	Mojaveryazdi, Farzaneh Sabbagh
author_sort	Mojaveryazdi, Farzaneh Sabbagh
title	Modified acrylamide hydrogel nanocomposites for varginal drug delivery system
title_short	Modified acrylamide hydrogel nanocomposites for varginal drug delivery system
title_full	Modified acrylamide hydrogel nanocomposites for varginal drug delivery system
title_fullStr	Modified acrylamide hydrogel nanocomposites for varginal drug delivery system
title_full_unstemmed	Modified acrylamide hydrogel nanocomposites for varginal drug delivery system
title_sort	modified acrylamide hydrogel nanocomposites for varginal drug delivery system
granting_institution	Universiti Teknologi Malaysia, Faculty of Chemical & Energy Engineering
granting_department	Faculty of Chemical & Energy Engineering
publishDate	2017
url	http://eprints.utm.my/id/eprint/79292/1/FarzanehSabbaghMojaveryazdiPFChE2017.pdf
_version_	1747818192824172544

Modified acrylamide hydrogel nanocomposites for varginal drug delivery system

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